摘要：多模态疗法是结合多种疗法治疗通常复杂而隐蔽的肿瘤组织的最有希望的策略之一.尽管多功能纳米材料已被设计用于构建多模态疗法,但普遍存在的各组成部分之间的不充分协调可能导致协同治疗效果不佳,并妨碍其充分实现临床潜力.在此,受可控“集束炸弹”模型的启发,我们设计了一种智能、生物相容、多功能的纳米工厂系统(PDA@GOx@MnO_(2)-PEG),它封装了多种纳米试剂,以达到对肿瘤组织的高破坏效率.刺激反应性的外层二氧化锰作为“炸弹”的外壳可触发级联催化反应,并与GOx形成一个自给自足的环形催化链.PDA作为一种具有良好蛋白质携带能力的基质,实现了高的GOx负载.同时,其高效的光热转换效率显示了低温(~45℃)进一步提高GOx酶活性的潜力.值得注意的是,内部的GOx就像一个“子炸弹”,通过控制释放来增加肿瘤缺氧部位的积累,并在充足的氧气和低热度的帮助下充分发挥其葡萄糖消耗能力进行饥饿治疗.在这个体系中,各种纳米试剂相互配合,层层推进,充分发挥其威力,形成了一个自给自足的纳米工厂模型,通过协同策略实现了良好的低温光热-饥饿协同治疗.此外,该纳米复合材料表现出三态成像能力,可用于敏感诊断和实时监控治疗.这项研究为设计生物相容性和智能治疗纳米平台提供了新的见解,使精准医疗中的多模式治疗效果最大化.

摘要：研究目的:为改善实际工程结构在不确定性条件下的多性能指标,提供一种高效的区间多目标优化方法。创新要点:建立一个目标和约束均为区间不确定性参数函数的区间约束多目标优化模型,提出并实现基于径向基函数、区间分析和非支配排序遗传算法(NSGA-II)的区间多目标优化算法。研究方法:首先,利用区间序关系将每个区间目标转换为同时优化其中点和半径的确定性双目标,利用区间可能度法将区间约束转换为确定性约束,并在此基础上,利用加权法和罚函数法将每个区间目标的约束优化问题转换为相应的无约束优化问题;然后,利用拉丁超立方实验设计和有限元分析构建预测各待优化结构性能指标值的径向基函数;最后,将径向基函数、区间分析法与NSGA-II相结合,快速求出转换后确定性无约束多目标优化问题的所有Pareto最优解,并通过考虑材料不确定性的高速压力机滑块机构设计实例验证该方法的有效性。重要结论:目标和约束均为不确定性参数函数的区间多目标优化模型能有效反映实际工程中同时改善结构多性能指标的需求。基于径向基函数、区间分析和NSGA-II相结合的区间多目标优化算法将传统区间优化模型求解中的嵌套优化过程简化为单层遗传优化过程,大大提高了求解效率,并可获得多目标优化问题的所有Pareto最优解。

摘要：防冰热载荷分布预测是螺旋桨飞机防冰系统设计的关键,目前对螺旋桨飞机防冰热载荷的研究却十分匮乏。基于多参考系和Messinger热力学模型对三维螺旋桨进行了模拟,分析了防冰热载荷的影响。结果表明:防冰热载荷主要集中在叶片前缘,沿叶片展向先增大后减小;随着来流速度的增加,防冰功率及范围均先增大后减小。由于旋转效应的影响,迎角的影响可以忽略不计。此外,随着环境温度的降低,防冰功率呈线性增加。基于CCAR-25附录C规定的严重结冰条件,转速为660 r/min时,叶片的防冰范围在弦向上极限为2.1%,在弦向下极限为6.7%;防冰最大功率为9.5 kW/m2。单台螺旋桨防冰功率超过1.96 kW。本研究为螺旋桨飞机的表面防冰提供了科学的解释,为螺旋桨飞机防冰系统的安装提供了理论依据。

摘要：钽(Ta)是一种关键高科技金属,在电工电子、航空航天等战略新兴产业中都有重要应用。当前尚无钽的替代材料,近20年来全球钽供应危机不断加剧。本工作对钽资源及其生产进行全面综述。地壳中已查明Ta储量不足300 kt,钽的提取以钽精矿为主要原料,此外,锡冶炼渣、锂矿石、废钽产品也能生产约37%的金属钽。钽的生产是一个高耗能过程,HF浸出-溶剂萃取-K2TaF7还原工艺是工业上制Ta最常用的工艺,但较高的生产成本和大量废弃物的产生是制约该方法可持续发展的重要因素。钽的清洁生产及高效回收将受到持续关注。

摘要：The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent *** this work,a nanoplatform for chemo-photothermal therapy with targeting ligand was *** porous structured silica nanotubes(SNTs)with controllable lengths decorated with CuS nanoparticles(NPs)on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell *** with average lengths of 40,55 and 150 nm were obtained and further functionalized as drug *** smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 *** release of doxorubicin hydrochloride(DOX)from the SNTs was dependent on the p H of the buffer solution and 808-nm near infrared(NIR)light *** integration of photothermal therapy(PTT)of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in *** results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.

摘要：Human body communication is proposed as a promising body proximal comanunication tech- nology for body sensor networks. To achieve low power and slmll volume ill the sensor nodes, a Ra-dio Frequency （RF） application-specific integrated circuit transceiver tbr Human Body Commnunication （HBC） is presented and the characteristics of HBC are investigated. A high data rate On-Off Keying （OOK）/Frequency-Shift Keying （FSK） modulation protocol and an OOK/FSK delrodulator circuit are introduced in this paper, with a data-rate-to-carrier-frequency ratio up to 70%. A low noise amplifier is proposed to handle the dynamic range problem and improve the sensitivity of the receiver path. In addi-tion, a low power autonmatic-gain-control system is realized using a novel architecture, thereby render-ing the peak detector circuit and loop filter unneces-sary. Finally, the complete chip is fabricated. Simula-tion results suggest receiver sensitivity to be-75 dBm. The transceiver shows an overall power con-smxption of 32 mW when data rate is 5 Mbps, de-livering a P1dB output power of - 30 dBm.

摘要：CAD model with nominal dimension is implemented in interference checking of assembly simulation of aircraft complex parts at present, which causes inadequate availability. In order to address this challenging issue, interference checking method with tolerance based on assembly dimension chain was proposed. Worst case and maximum error probability of tolerance of composing loop were used, and CAD models were respectively re-constructed and inserted into simulation system. Before dynamic interference checking, engineering semantic interference condition was set to assembly requirements. Finally, the interface checking result was a basis for reasonability of assembly process and tolerance. A prototype system was developed based on the above research.

摘要：本文介绍了一种用于多材料拓扑优化中分配两种不同材料的新策略.基于单一材料的双向渐进结构优化(BESO)法开发的多材料双向渐进结构优化(MBESO)法能够有效的处理诸如钢-混凝土这种双材料结构的拓扑优化问题.然而,在一些特殊情况下,使用MBESO方法设计的多材料结构中,部分受压材料可能会出现受压超限导致结构不安全的情况.为了解决这种关键问题,本文提出了一种简单而有效的材料分布策略.例如在钢-混凝土结构中,部分压应力过大的混凝土材料可以用钢材替代.在压力最大的局部区域布置少量的钢材可以有效地将混凝土材料的最大压应力降至安全水平.本文通过一系列2D和3D案例的对比研究表明,相比于原始的MBESO方法,改进的双材料分布策略可以有效的解决双材料拓扑优化结构中局部压应力过大的情况,证明了该方法在增强拓扑优化复合结构的安全性方面的有效性,显示出该材料分配策略在多材料拓扑优化研究和应用中的巨大潜力和价值.

摘要：由人工结构组成的超材料具有传统材料不具备的卓越性能.通过设计和排列具有特殊物理性质的单元结构可制备用于高效电磁波吸收的吸波超材料.这些亚波长尺度的单元结构是吸波超材料超越传统材料性能极限的基础,因此制造工艺的匹配尤为重要.快速发展的3D打印技术在制造具有复杂结构的材料方面展现出巨大的优势和潜力,为研究和制备吸波超材料提供了一种简单、快速、高效的方法.在这篇综述中,我们介绍了吸波超材料的概念和发展,重点介绍了利用3D打印技术制造吸波超材料的研究现状.此外,还简要介绍了超材料的典型应用,讨论了当前超材料发展的不足和3D打印技术制备吸波超材料的局限性,并提出了超材料和3D打印技术结合的发展前景.

摘要：In order to effectively detect malicious phishing behaviors, a phishing detection method based on the uniform resource locator （URL） features is proposed. First, the method compares the phishing URLs with legal ones to extract the features of phishing URLs. Then a machine learning algorithm is applied to obtain the URL classification model from the sample data set training. In order to adapt to the change of a phishing URL, the classification model should be constantly updated according to the new samples. So, an incremental learning algorithm based on the feedback of the original sample data set is designed. The experiments verify that the combination of the URL features extracted in this paper and the support vector machine （SVM） classification algorithm can achieve a high phishing detection accuracy, and the incremental learning algorithm is also effective.