摘要：An end-effector for a flexible drilling robot is designed, and a novel four-point algorithm of normal attitude regulation for this end-effector is presented. Four non-coplanar points can define a unique sphere tangent to them in spatial geometry, and the center point of the sphere and the radius can be calculated. The shape of a workpiece surface in the machining area is approximately regarded as such a sphere. A vector from the machining point to the center point is thus approximately regarded as a normal vector to the workpiece surface. By this principle, the algorithm first measures four coordinates on the curve in the drilling region using four sensors and calculates the normal vector at the drilling point, then calculates the error between the normal vector and the axis of the spindle. According to this error, the algorithm further figures out the angles of two revolving axes on the end- effector and the displacements of three linear axes on the robot main body, thus it implements the function of adjusting the spindle to be perpendicular to the curve at the drilling point. Simulation results of two kinds of curved surfaces show that accuracy and efficiency can be realized using the proposed algorithm.

摘要：Images are widely used by companies to advertise their products and promote awareness of their *** automatic synthesis of advertising images is challenging because the advertising message must be clearly conveyed while complying with the style required for the product,brand,or target *** this study,we proposed a data-driven method to capture individual design attributes and the relationships between elements in advertising images with the aim of automatically synthesizing the input of elements into an advertising image according to a specified *** achieve this multi-format advertisement design,we created a dataset containing 13280 advertising images with rich annotations that encompassed the outlines and colors of the elements,in addition to the classes and goals of the *** our probabilistic models,users guided the style of synthesized advertisements via additional constraints(e.g.,context-based keywords).We applied our method to a variety of design tasks,and the results were evaluated in several perceptual studies,which showed that our method improved users’satisfaction by 7.1%compared to designs generated by nonprofessional students,and that more users preferred the coloring results of our designs to those generated by the color harmony model and Colormind.

摘要：A great number of pipelines in China are in unsatisfactory condition and faced with problems of corrosion and cracking,but there are very few approaches for underwater pipeline *** detection autonomous underwater vehicle(PDAUV) is hereby designed to solve these problems when working with advanced optical,acoustical and electrical sensors for underwater pipeline *** is a test bed that not only examines the logical rationality of the program,effectiveness of the hardware architecture,accuracy of the software interface protocol as well as the reliability and stability of the control system but also verifies the effectiveness of the control system in tank experiments and sea *** motion control system of PDAUV,including both the hardware and software architectures,is introduced in this *** software module and information flow of the motion control system of PDAUV and a novel neural network-based control(NNC) are also ***,a real-time identification method based on neural network is used to realize system *** tank experiments and sea trials are carried out to verify the feasibility and capability of PDAUV control system to complete underwater pipeline detection task.

摘要：Extracellular vesicles(EVs)are lipid-bound vesicles secreted by cells into the extracellular *** are three types of EVs,including exosomes(30–150 nm)[1],microvesicles(100–1000 nm),and apoptotic bodies(50–4000 nm).EVs are also important intercellular communication carriers in many physiological and pathological processes such as immune response,tumor invasion,and metastasis[2,3].EVs circulate in various body fluids(e.g.,peripheral blood and urine),while carrying genetic information(e.g.,proteins and nucleic acids)from the parent cells[2,4,5].Thus,their source can be identified through gene analysis[6–10].

摘要：A BiOCl-Bi12O17Cl2 nanocomposite with a high visible-light response and a low photoinduced electron-hole pair recombination rate was successfully synthesized using an ultrasonic-hydrothermal *** texture,structure,optical,and photocatalytic properties of the composite were *** results showed that the composite had a sheet flower-like structure with a large specific surface ***-visible diffuse reflection spectra and photoluminescence spectra showed that the composite had an excellent visible-light response and a low recombination rate of photoinduced electron hole *** photocatalytic property of the composite was evaluated by the removal efficiency of rhodamine B and ciprofloxacin under visible-light *** composite’s reaction rate constant of removing rhodamine B(/ciprofloxacin)was approximately 8.14(/4.94),42.63(/11.91)and 64.66(/36.07)times that of Bi12O17Cl2,P25,and BiOCl,***,the composite showed a wide applicable pH range and excellent *** analysis showed that photogenerated holes played a dominant role and·O2–also contributed to photocatalytic *** summary,this study presents a high-efficiency photocatalyst for wastewater treatment.

摘要：The thioredoxin system plays a role in a variety of physiological functions, including cell growth, differenti- ation, apoptosis, tumorigenesis, and immunity. We previously confirmed that butaselen （BS）, a novel thioredoxin reductase inhibitor, can inhibit the growth of various human cancer cell lines, yet the underlying mechanism remains elusive. In this study, we investigated the anti-tumor effect of BS in vivo through regulating the immune system of KM mice. We found that BS inhibits tumor proliferation by promoting the activation of splenic lymphocytes in mice. BS can elevate the percentage of CD^4-CD8^＋ T lymphocytes and the secretion of downstream cytokines in mice via downregulating the expression of programmed death-ligand 1 （PD-L1） on the tumor cells＇ surface in vivo. Further study in HepG2 and BEL-7402 cells showed that decrease of PD-L1 level after BS treatment was achieved by inhibiting signal transducer and activator of transcription 3 （STAT3） phosphorylation. Taken together, our results suggest that BS has a role in promoting the immune response by reducing PD-L1 expression via the STAT3 pathway, and subsequently suppresses tumorigenesis.

摘要：To address the environmental and health hazards of nitrate(NO_(3)^(-))in water,a denitrification advanced reduction process(ARP)using only formic acid(HCOOH)activated by ultraviolet(UV)light was *** efficiency,influencing factors,mechanism,and kinetics of the reduction were investigated through component analysis and radical *** show that,after 90 min of UV illumination,the reduction and gas conversion ratios of 50 mg/L NO_(3)^(-)-N reach 99.9%and 99.8%,respectively,under 9 mM of C_(0)(HCOOH),pH=3.0,and N_(2) ***,96.7%of HCOOH is consumed and converted into *** NO_(3)^(-)-N conversion process includes the transformation to NO_(2)^(-)-N,followed by a further reduction to gas and a direct conversion into gas,introducing small amounts of nitrite and *** carbon dioxide anion radical(·CO_(2)^(-))from HCOOH/HCOO^(-)is the principal cause of NO_(3)^(-)-N reduction by UV/HCOOH/N 2 *** contrast,·CO_(2)^(-)production is caused by the hydroxyl radical(·OH).The NO_(3)^(-)-N reduction efficiency is enhanced by the increase in the light intensity,considerably affected by the initial pH,and less affected by inorganic anions,including Cl^(-),H_(2)PO_(4)^(-),and HCO_(3)^(-)/CO_(3)^(2-).The initial HCOOH concentration and light intensity are the main factors that influence the NO_(3)^(-)-N reduction rate.

摘要：The strengths weaknesses opportunities and threats SWOT analysis method is applied to assess the feasibility of traditional stormwater management and low impact development LID in *** results show that traditional stormwater management has many disadvantages *** stormwater collection and discharge or flooding peak-flow regulation is taken into consideration but lack of many important functions such as on-site infiltration non-point pollution control ecological treatment *** as a new stormwater management concept the LID system has many advantages *** can not only control rainwater quantity but also effectively prevent non-point pollution. Moreover LID is easy for implementation and cost effective and operation and management can also be done *** has attracted more and more attention from governmental authorities at different levels and the majority of practitioners. Therefore LID has bright prospects for wide applications in China.

摘要：A tri-port MIMO antenna designed for Micro/Pico-Cell application is *** is based on printed elements with X-shaped arms,which are oriented to 0°,120° and240° in the azimuth *** arms of these elements are connected,with which a selfdecoupled structure is *** mutual coupling between adjacent elements is below-15 ***,it size is compact and bidirectional radiation patterns with around 4dBi Gain and 92° 3dB beam width is achieved,which can provide good pattern diversity and full azimuth coverage in real applications.

摘要：The traditional zinc hydro-metallurgy generates a large amount of zinc ferrite residue rich in valuable metals. The separation of iron is crucial for resource recycling of valuable metals in zinc ferrite residue. A novel selective reduction roasting？leaching process was proposed to separate zinc and iron from zinc leaching residue which contains zinc ferrite. The thermodynamic analysis was employed to determine the predominant range of Fe3O4 and ZnO during reduction roasting process of zinc ferrite. Based on the result of thermodynamic calculation, we found thatV（CO）/V（CO＋CO2） ratio is a key factor determining the phase composition in the reduction roasting product of zinc ferrite. In the range ofV（CO）/V（CO＋CO2） ratio between 2.68% and 36.18%, zinc ferrite is preferentially decomposed into Fe3O4 and ZnO. Based on thermogravimetric （TG） analysis, the optimal conditions for reduction roasting of zinc ferrite are determined as follows： temperature 700？750 °C, volume fraction of CO 6% and V（CO）/V（CO＋CO2） ratio 30%. Based on the above results, zinc leaching residue rich in zinc ferrite was roasted and the roasted product was leached by acid solution. It is found that zinc extraction rate in zinc leaching residue reaches up to 70% and iron extraction rate is only 18.4%. The result indicates that zinc and iron can be effectively separated from zinc leaching residue.