摘要：交通、船舰、机场等应用领域的信号灯、探照灯容易受到天气因素的影响,本文通过实验比较了不同颜色LED光源在淡水雾和海雾中的穿透性能,并研究了淡水雾中LED光源的透光性与距离的关系.结果显示:各种颜色LED光源在雾中的透射率随距离呈指数关系下降;而且,淡水雾和海水雾中,黄光LED的透过率均为最大.本研究工作为信号灯、探照灯等功能照明提供了设计依据.

摘要：牙菌斑是造成龋病及牙周病的主要因素之一,通过检测牙齿表面牙菌斑含量多少能在一定程度上了解牙齿健康程度,对口腔健康的维护有重要意义。利用牙菌斑与牙齿组织自体荧光光谱的差异性,本文设计了一套便携式的基于自体荧光成像的检测系统。(1)该系统以中心波长为405nm的LED作为激发光源,辅以中心波长520nm的长波通滤光片提高系统信噪比,CCD作为感光器件;系统采集荧光图像后,根据成像结果分析牙面上牙菌斑含量。(2)设计了验证实验采集受试者牙齿图像,并以牙菌斑百分比作为量化牙菌斑多少的指标。实验结果表明荧光图像菌斑百分比与Turesky改良的Quigley-Hein菌斑指数的Spearman等级相关系数为0.944,牙齿荧光图像牙菌斑百分比与染色图像牙菌斑百分比的Pearson相关系数为0.875。由此可见,文中的检测系统具有较好的准确性,而且因为采用光学检测方法,具有非侵入性且可重复性,所以它有广阔的临床应用前景,有望成为家用口腔健康的检查手段。

摘要：Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment.

摘要：Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic ***,current organ-on-a-chip platforms are limited by a“single pot”design,which inevitably requires holistic analysis and limits parallel ***,we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres,which significantly increased the parallelism over traditional organ-on-a-chip for drug *** to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units,allowing for analysis with high consistency and quick *** platform displayed evident anti-cancer efficacy at a concentration of 10μM for sorafenib,and had greater alignment than the“single pot”organ-on-a-chip with a previous in vivo *** addition,this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50μg/*** successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities,thereby accelerating the joint endeavor to combat cancer.

摘要：Recently,Kelly and colleagues[1],inspired by computed tomography(CT),report a“volumetric additive manufacturing”technology via a computed axial lithography(CAL)approach.A related US patent application[2]has also been *** cumulative light exposure solidifies the material in the target area,while the other area remains uncured,resulting in only specific points in the designed 3D objects being *** technology significantly improves the capability of the digital light processing(DLP)***,the lithography approach based on a similar algorithm was already proposed by Xiang Wu in a patent(application ***/CN2016/080097)in 2016[3].

摘要：Cancer is characterized by a high fatality rate,complex molecular mechanism,and costly *** microenvironment of a tumor consists of multiple biochemical cues and the interaction between tumor cells,stromal cells,and extracellular matrix plays a key role in tumor initiation,development,angiogenesis,invasion and *** better understand the biological features of tumor and reveal the critical factors of therapeutic treatments against cancer,it is of great significance to build in vitro tumor models that could recapitulate the stages of tumor progression and mimic tumor behaviors in vivo for efficient and patient-specific drug screening and biological *** conventional tissue engineering methods of constructing tumor models always fail to simulate the later stages of tumor development due to the lack of ability to build complex structures and angiogenesis potential,three-dimensional(3D)bioprinting techniques have gradually found its applications in tumor microenvironment modeling with accurate composition and well-organized spatial distribution of tumor-related cells and extracellular components in the past *** capabilities of building tumor models with a large range of scale,complex structures,multiple biomaterials and vascular network with high resolution and throughput make 3D bioprinting become a versatile platform in bio-manufacturing aswell as inmedical *** this review,wewill focus on 3D bioprinting strategies,design of bioinks,current 3D bioprinted tumor models in vitro classified with their structures and propose future perspectives.

摘要：Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent *** the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in ***,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment *** study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study.

摘要：采用纤芯间距为38.78μm的国产多芯光纤设计了一种光纤弯曲传感器.该多芯光纤弯曲传感器由长度为1m的七芯光纤与单模光纤拼接制成,多芯光纤弯曲时,相邻的纤芯发生模式耦合.在传感器一侧,将宽带光注入到位于多芯光纤中心的纤芯,用光谱分析仪测量带有曲率信息的频谱,获得弯曲传感器的透射谱波长偏移与弯曲曲率半径的关系.结果表明:多芯光纤弯曲半径越小,弯曲曲率越大,串扰越明显.

摘要：The degnmming pretreatment mechanism was investigated to improve degnmming performance and the spinnability of degummed fibers. Apocynum was treated with redox system in the degumming pretreatment process and the pretreatment parameters had been optimized, besides the effects of pretreatment on property index of degnmmed apocynum fiber were investigated. The results showed that the redox system degumming process reduced alkali boiling time and had good advantages over the traditional degumming process in extraction rate, single fiber length and strength. SEM was used to test the longitudinal morphology changes of fibers before and after pretreatment. At the same time, pretreatment solution was analyzed by UV spectra and electron paramagnetic resonance spectrometer （ESR）, and its pH value was also tested. The results showed that the pretreatment solution could release acid constantly to keep the stability of the pH which caused the swelling and dissolution of pectic substances in apocynum bast. Meanwhile, pretrcatment solution could activate the free radicals from apocynam bast and reduce the activation energy of non- cellulosic composition in apocynum bast.

摘要：采用全矢量有限元方法进行光纤设计优化,得到横截面上失去两层空气洞的双芯光子晶体光纤,可用于液压传感.优化的双芯光子晶体光纤的模场半径和数值孔径与单模光纤基本一致,在优化的双芯光子晶体光纤和单模光纤之间有一个相对较低的熔接损耗.计算结果表明由模场半径和数值孔径导致的不匹配造成的总共损耗可低至0.026dB,低于传统光子晶体光纤和单模光纤0.1dB的直接熔接损耗.对基于20cm双芯光子晶体光纤的液压传感器的性能进行研究,结果表明在0~500 MPa量程内的灵敏度为-1.6pm/MPa.