摘要：Heart diseases remain the top threat to human health,and the treatment of heart diseases changes with each passing *** evidence shows that three-dimensional(3d)printing allows for a more precise understanding of the complex anatomy associated with various heart *** addition,3d-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical *** introduce examples of the clinical applications of different types of 3d printing based on specific cases and clinical application scenarios of 3d printing in treating heart *** also discuss the limitations and clinically unmet needs of 3d printing in this context.

摘要：Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological *** aim of this study was to examine the influence of very high baseline HIV-rNA levels on long-term virological responses under one type of ***:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to december *** HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based *** patients had baseline HIV-rNA levels over 500 copies/ml,good adherence,and were followed for at least 24 *** suppression was defined as the first HIV-rNA<50 copies/*** failure was defined as any of incomplete viral suppression(HIV-rNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-rNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load ***:A total of 758 treatment-naïve HIV patients in China were *** follow-up time(IQr)was 144(108–276)*** week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOr]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOr=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-rNA were related with delayed efficacy of NNrTI-based ArT and increased risk of treatment failure.

摘要：长时间工作或环境变化时,红外焦平面阵列器件易产生非均匀性的问题。典型的星上定标方法是将系统指向深空场景或在入瞳处引入星上面源黑体辐射。覆盖全口径的星上黑体普遍体积较大、设计复杂且成本高昂。为了解决这些难题,我们提出了一种基于可控内定标装置和星空场景的红外遥感系统星上非均匀性校正方法。该方法利用可控内定标源提供不同的靶面基准辐照度,通过计算获得不同辐射定标段的定标参数,覆盖探测器动态范围,实现不遮挡视场情况下的高动态范围非均匀性校正。通过模拟指向深空场景的在轨定标过程,并对模拟图像进行非均匀性校正,用于非均匀性校正的评价图像的非均匀性由初始的15.87%下降到1.2%以下。本方法具有快速、高效、鲁棒性强等优点且具有实时处理的前景。相比于需要引入星上面源黑体的定标方法,本系统的内定标装置结构简单、设计小型化且节省成本。

摘要：Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer ***,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these *** this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PdA)in an alkaline ***,HA and Ag nanoparticles were grown in situ on the PdA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering *** showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical *** body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent *** vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia ***,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.