摘要：Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

摘要：Bioprinting has been widely investigated for tissue engineering and regenerative medicine ***,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based ***,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell *** study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell *** printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous *** utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.

摘要：Urban development is becoming increasingly reliant on effective use of intelligent *** the process of providing better services to all citizens and improving the efficiency of administration processes,the concept of a smart city has been lauded as a promising solution for the coming challenge of global ***,due to the broad scope of smart cities their definition has not been standardized,thus proposed architectures are *** work proposes a new architecture from the perspective of the data that underpins all the functionality of smart *** proposed architecture is discussed,outlining design challenges and offering insight into the development of smart cities.

摘要：灵巧的策略为 Fe 的制造被设计 3 O 4 -nanoparticle-decorated TiO 2 nanofiber 由联合 electrospinning 技术的通用性的层次 heterostructures ( FTH )并且热水的生长方法。Fe 的层次建筑学 3 O 在 TiO 上装饰的 4 nanoparticles 2 nanofibers 启用进电池合成的二进制代码的成功的集成到地址结构的稳定性和低能力。在结果 FTH 的唯一的建筑学， 1D heterostructures 减轻 Fe 的严重的卷变化引起的紧张 3 O 4 在众多的费用分泌物周期期间，并且这样压制电极材料的降级。作为结果， FTH 包括更高可逆的能力显示出优秀性能，优秀周期生活，并且在由于 TiO 的二进制作文的 synergistic 效果的一个宽温度范围上的好率性能 2 和 Fe 3 O 4 和唯一的特征层次 nanofibers 。

摘要：作为一种典型的失效行为,动态断裂对于材料安全评估和设计至关重要,而动态断裂的瞬时性给实验表征裂纹尖端局部温度场演化带来了巨大挑战.研究人员指出温度对断裂韧性有显著影响,但在动态断裂起裂过程中,温度升高和裂纹尖端区域热软化效应的作用仍需阐明.本工作旨在评估温升效应对TC4(Ti-6Al-4V)合金受冲击动态断裂起裂的影响.我们开发了一种力/热耦合在位测试装置,获得了高时间/空间分辨率的动态I型断裂的同步COD(裂纹尖端张开位移)和温度场演化过程,并进行了相应的模拟,分析了动态断裂起裂时的热软化效应的作用.对于TC4合金,起裂时刻测得的最高温度约为130,热效应对材料性能的影响较小.本工作的结果为研究金属的力/热耦合断裂行为提供了数据支持.

摘要：针对尾座式飞行器过渡阶段动力学模型的大范围非线性变化问题,结合保护映射理论和H∞控制理论设计自适应控制增益调度技术。将提出的自适应控制增益调度技术对尾座式飞行器过渡过程的纵向模型进行航迹角跟踪,并与传统的基于增益调度技术的LQR方法进行对比。仿真结果表明:基于保护映射理论设计的控制器能够自主切换合适的控制律,完成过渡过程的稳定转换,并且本文方法比基于传统增益调度技术的LQR方法显示出了更好的跟踪性能。

摘要：Tissue-engineered cartilage(TEC)remains a potential alternative for the repair of articular cartilage ***,there has been a significant different between the properties of TEC and those of natural *** have shown that mechanical stimulation such as compressive load can help regulate matrix remodelling in TEC,thus affecting its biomechanical ***,the influences of shear induced from the tissue fluid phase have not been well studied and may play an important role in tissue regeneration especially when integrated with the compressive ***,the aim of this study was to quantitatively investigate the effects of combined loading mechanisms on TEC in vitro.A bespoke biosimulator was built to incorporate the coupled motion of compression,friction and *** specimens,encapsulating freshly isolated rabbit chondrocytes in a hydrogel,were cultured within the biosimulator under various mechanical stimulations for 4 weeks,and the tissue activity,matrix contents and the mechanical properties were *** groups were categorized according to different mechanical stimulation combinations,including strain(5-20%at 5%intervals)and frequency(0.25 Hz,0.5 Hz,1 Hz),and the effects on tissue behaviour were *** the dynamic culture process,a combined load was applied to simulate the combined effects of compression,friction and shear on articular cartilage during human *** results indicated that a larger strain and higher frequency were more favourable for the specimen in terms of the cell proliferation and extracellular matrix ***,the combined mechanical stimulation was more beneficial to matrix remodelling than the single loading ***,the contribution of the combined mechanical stimulation to the engineered cartilaginous tissue matrix was not sufficient to impede biodegradation of the tissue with culture time.

摘要：在以往的电动汽车驱动电机设计中,经常忽略电机的电磁振动噪声问题,这无疑会降低车用电机的运行可靠性和使用寿命。为此,本文以一台车用内置式永磁同步电机为例,提出了一种在驱动电机电磁设计时进行电磁振动噪声分析和优化的方法。首先,基于电磁场理论和麦克斯韦应力张量法,推导并分析了引起电机电磁振动噪声的主要因素——气隙电磁力的主要空间和时间谐波构成。其次,通过建立电机电磁‐结构‐声多物理场耦合仿真模型,仿真分析了电机气隙径向电磁力时空谐波分布和定子模态分布,并初步计算了电机在高速工况下的振动和噪声性能。然后,结合有限元分析和现代优化算法,提出了一种在电磁设计阶段进行驱动电机电磁振动和噪声性能的优化方法。最后,通过所提出的电磁振动噪声优化方法改善了一台内置式永磁同步电机的电磁振动和噪声性能,并通过对比优化前后电机的电磁振动噪声性能,验证了所提出优化方法的可行性和有效性。

摘要：为研究节理与层理面对裂隙层状岩体裂纹演化的共同作用,对不同层理面倾角下,含多角度共面双节理的双层复合类岩试样进行单轴压缩试验和数字图像相关试验。由试验结果可知,层理面和节理对应力−应变曲线特征和强度参数有显著影响。试件的破坏模式分为4种不同类型。层理面的存在抑制了岩桥区域裂纹的贯通,层理面倾角的变化对裂纹扩展路径和破坏模式的转变有较大影响。对于层理面倾角为30°和45°的试件,节理倾角越大,层理面对试件破坏特征的影响越小。此外,观测到一种从层理面上萌生并且更容易在试件上层扩展的拉伸裂纹。

摘要：mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成，金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时， nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半，基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一， cyclodextrin (， CD ) 更暗淡的桥牌。在 vitro，研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了，为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成， MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点，显著地从而改进治疗学的功效。