摘要：As future soft robotic devices necessitate a level of complexity surpassing current standards,a new design approach is needed that integrates multiple systems necessary to synchronize the motions of soft actuators and the response of signals,thereby enhancing the intelligence of flexible ***,we propose a liquid crystal elastomer unit cell-based platform that organizes the cells in a group to create expandable *** unit cell behaves like a flexible module that can expand biaxially into a specific,stable,and controllable *** the unit cells in different manners results in an adaptable soft grasper,a half-adder for information processing,and a tunable phononic *** implies a high level of reconfigurability and scalability in both structures and functions by elegantly reassembling the unit *** design strategy has the potential to integrate multiple functions that traditional soft actuators cannot accommodate,providing a platform for developing intelligent soft robotics.

摘要：Immune evasion behavior and immunosuppressive characteristics of tumor extensively impedethe immune initiation effect of therapy triggered immunogeniccell death (ICD). In this work, a carrier-adjuvantedimmunostimulator (designated as CoCeC) is developed toboost photodynamic immunotherapy by downregulatingprogrammed death ligand 1 (PD-L1) and impairing adenosinetriphosphate (ATP) hydrolysis. Among these, the crosslinkedchitosan oligosaccharide is applied as the drug carrier fordelivery of Ce6 and Ceritinib, which also serves as an immuneadjuvant to downregulate PD-L1. Meanwhile, the robustphotodynamic therapy (PDT) of CoCeC exhibits lethal toxicityagainst tumor cells to induce ICD and release damage-associated molecular patterns (DAMPs), which can also impairATP hydrolysis by blocking CD39. In vitro and in vivo resultsdemonstrate the robust therapeutic efficacy of CoCeC tosuppress primary tumor growth and activate a superior immune elimination against lung metastasis by amplifying theimmune initiation of ICD with the assistance of immune *** work provides a self-adjuvanted strategy to enhance the immune response of therapy induced ICD, which ispromising to activate systemic antitumor immunity in consideration of the complicated immunosuppressive factors.

摘要：Zero-dimensional perovskite materials,characterized by broadband emission caused by self-trapped excitons,are promising materials for stimuli-responsive and photo-writeable ***,existing research is focused on the effects of structural phase transitions on photophysical properties,and lacks in-depth understanding of the mechanisms of self-trapped excitons ***,we demonstrate that the dehydration reaction in zero-dimensional antimony halide clusters significantly enhances the self-trapped excitons emission without inducing structural phase transition,resulting in a substantial increase in photoluminescence(PL)quantum yield from 3.5%to 91.4%.In-situ X-ray diffraction and PL techniques were employed to shed light on the relationship between the crystal structure and radiative recombination,demonstrating the introduction of rich lattice distortion during the dehydration ***-dependent PL spectra and transient absorption spectra suggest that the lattice distortion causes the moderate electron-phonon coupling strength and high exciton binding energy,facilitating self-trapped excitons to relax from the non-radiative recombination singlet state to the radiative recombination triplet state,corresponding to the enhanced emission *** a proof of concept,several switchable PL applications have been established in scenarios such as anti-counterfeiting,rewritable luminescent paper,and humidity *** finding elucidates the emission mechanism of self-trapped excitons and provides a novel avenue for designing switchable luminescent materials.

摘要：β-Lapachone (β-Lap) is a promising orthonaphthoquinone drug for cancer treatment and has been inclinical trials. Its application is constrained by the low aqueoussolubility, and severe side effects. Even prodrug designation isan effective approach to render it with tumor selectivity, it islimited by the lack of modifiable groups on β-Lap. Herein, anovel azo bond primary cleavage and carbon–carbon (C–C)bond secondary cleavage-based polymeric β-Lap prodrug(Azo-Lap NP) is designed, in which the self-immolated paraaminobenzyl linker is connected to poly(L-glutamic acid)(PGlu) via azo linkage and the responsive drug release of β-Lapagainst tumors can be achieved under high NAD(P)H:quinoneoxidoreductase 1 (NQO1) expression and low pH environmentin tumors. The effective covalent loading of β-Lap by Azo-LapNPs permitted a high administration dose of β-Lap and enabled significant tumor retention time. Moreover, Azo-LapNPs markedly reduced the side effects of β-Lap by avoidinghemolysis and the production of methemoglobin. The safety ofAzo-Lap NPs administration is validated in the antitumorexperiment of mice. In the 4T1 model, Azo-Lap NPs exhibiteda markedly higher tumor suppression rate than β-Lap. Thiswork provides an effective and safe polymeric prodrug fortumor selective delivery of β-Lap.

摘要：The martensitic transformation temperature is the basis for the application of shape memory alloys(SMAs),and the ability to quickly and accurately predict the transformation temperature of SMAs has very important practical *** this work,machine learning(ML)methods were utilized to accelerate the search for shape memory alloys with targeted properties(phase transition temperature).A group of component data was selected to design shape memory alloys using reverse design method from numerous unexplored *** modeling and feature modeling were used to predict the phase transition temperature of the shape memory *** experimental results of the shape memory alloys were obtained to verify the effectiveness of the support vector regression(SVR)*** results show that the machine learning model can obtain target materials more efficiently and pertinently,and realize the accurate and rapid design of shape memory alloys with specific target phase transition *** this basis,the relationship between phase transition temperature and material descriptors is analyzed,and it is proved that the key factors affecting the phase transition temperature of shape memory alloys are based on the strength of the bond energy between *** work provides new ideas for the controllable design and performance optimization of Cu-based shape memory alloys.

摘要：The purpose of this paper is to improve the aerodynamic performances of the last stage turbine and the exhaust hood of a 600MW steam turbine under design and off design conditions. During operation, strong flow interactions between the turbine and the exhaust hood impose influences on the flow behavior in the hood and lead to the unsatisfactory aerodynamic performance of the turbine and exhaust hood. So the exhaust hood has the potential to be improved in terms of aerodynamic efficiency. Considering the flow interactions between the turbine and the exhaust hood, the profiles of the diffuser end-wall were optimized. The coupled model turbine and model exhaust hood calculations and experiments were carried out to validate the effects of the optimization. Model experiments show that the design modifications resulted in a substantial increase in the overall pressure recovery coefficient. The flow and aerodynamic performances of the full-scale last stage turbine and full-scale exhaust hood were simulated to explore the flow physics alterations to the modification of diffuser geometry. The wet steam was selected as the flow medium. The actual flow fields trader different operation conditions were analyzed.

摘要：Based on the experimental data from hot compression tests on Gleeble 1500 thermal simulator, the revised constitutive equations of spray-formed FGH95 superalloy considering the effect of strain on the material constants were established. The average absolute relative error （AARE） was employed to verify the validity of the constitutive equation, and the value of AARE is 3.85 %. Subsequently, the revised constitutive equations were successfully used to simulate and analyze the deformation behavior, stress distribution, forming loads and temperature distribution in both dies and billet during the isothermal forging process of turbine disk of large dimension （about 400 mm in diameter） by the means of finite element method （FEM）. Moreover, the optimum process parameters are 1,120 ℃ of forging temperature and 0.01 s^-1 of strain rate for the spray-formed FGH95 superalloy turbine disk.

摘要：Nanomaterials are materials in which at least one of the dimensions of the particles is 100 nm and *** are many types of nanomaterials,but noble metal nanoparticles are of interest due to their uniquely large surface-to-volume ratio,high surface area,optical and electronic properties,high stability,easy synthesis,and tunable surface *** importantly,noble metal nanoparticles are known to have excellent compatibility with bio-materials,which is why they are widely used in biological *** synthesis method of noble metal nanoparticles conventionally involves the reduction of the noble metal salt precursor by toxic reaction agents such as NaBH4,hydrazine,and *** is a major drawback for researchers involved in biological application ***,the bio-synthesis of noble metal nanoparticles(NPs)by bio-materials via bio-reduction provides an alternative method to synthesize noble metal nanoparticles which are potentially non-toxic and safer for biological *** this review,the bio-synthesis of noble metal nanoparticle including gold nanoparticle(AuNPs),silver nanoparticle(AgNPs),platinum nanoparticle(PtNPs),and palladium nanoparticle(PdNPs)are first *** is followed by a discussion of these biosynthesized noble metal in biological applications including antimicrobial,wound healing,anticancer drug,and *** on these,it can be concluded that the study on bio-synthesized noble metal nanoparticles will expand further involving bio-reduction by unexplored ***,many questions remain on the feasibility of bio-synthesized noble metal nanoparticles to replace existing methods on various biological ***,the current development of the biological application by bio-synthesized noble metal NPs is still intensively ongoing,and will eventually reach the goal of full commercialization.

摘要：This study proposed a design and optimization strategy for a tandem arranged cascade using the Non-dominated Sorting Genetic Algorithm(NSGA) Ⅱ multi-objective optimization algorithm and Back Propagation(BP) neural network technology. The NASA Stage 35 was employed as the initial bench mark in the present study and five geometric control parameters were working as the optimization parameters aiming to enhance the aerodynamic performance in terms of total pressure rise and efficiency. Results showed that the feasibility and capability of the proposed optimization strategy was successfully examined. In view of the fact that the initial tandem cascade(directly scaling down from NASA Stage 35) cannot guarantee the aerodynamic performance, first optimization trial was conducted to optimize the initial design. Results showed that the optimum can improve the flow quality whereas the separation on the blade is decayed or even eliminated particularly at the tip and root regions. However, compared with the initial tandem design, the enhancement in total pressure ratio(0.47%) and efficiency(1%) are too small to be noticed. Second investigation was particularly emphasizing on a high turning tandem compressor with an increment by 28°. The pressure rise and efficiency were augmented by 1.44% and 2.34%(compared to the initial tandem design), respectively. An important conclusion can be drawn that the optimization strategy is worthy to be used in high turning compressors with a considerable performance improvement.

摘要：In this review,we primarily address the present state of the arts and latest progresses in a few frontier issues mostly relevant to free surface/interface in ocean *** include TC(tropical cyclone)induced extreme surface wave,sloshing of LNG(liquefied natural gas),cavitation/bubble dynamics and VIM(vortex-induced motion)and VIV(vortex-induced vibration).In addition to general description,we mainly focus on the recent advances and challenging aspects of above-mentioned *** by the achievements in the previous 70 years,mankind starts a new round of ocean exploration ***,we can find obvious trends:the realm of ocean engineering is expanding from sea surface to deep sea,from low and middle latitude to polar region and from fossil to renewable energy in near future.