摘要：A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.

摘要：The demand of high-end electromagnetic wave absorbing materials puts forward higher requirements on comprehensive performances of small thickness,lightweight,broadband,and strong ***,a novel multi-layer stepped metamaterial absorber with gradient electromagnetic properties is *** complex permittivity and permeability of each layer are tailored via the proportion of carbonyliron and carbon-fiber dispersing into the epoxy *** proposed metamaterial is further optimized via adjusting the electromagnetic parameters and geometric sizes of each *** with the four-layer composite with gradient electromagnetic properties which could only realize reflection loss(RL)of less than−6 dB in 2.0-40 GHz,the optimized stepped metamaterial with the same thickness and electromagnetic properties realizes less than−10 dB in the relevant frequency ***,the RL of less than−15 dB is achieved in the frequency range of 11.2-21.4 GHz and 28.5-40 *** multiple electromagnetic wave absorption mechanism is discussed based on the experimental and simulation results,which is believed to be attributed to the synergy effect induced by multi-scale structures of the ***,combining multi-layer structures and periodic stepped structures into a novel gradient absorbing metamaterial would give new insights into designing microwave absorption devices for broadband electromagnetic protections.

摘要：To overcome the trade-off between the devisable micro structure and the excellent tensile ductility of bulk metallic glass composites(BMGCs),a novel ex-situ and in-situ hybrid strategy is successfully proposed to design a series of the work-hardenable ductile Ti-based multilayered BMGCs(ML-BMGCs).The asprepared ML-BMGCs,consisting of α-phases,β-phases and amorphous phases,exhibit a controllable multilayered structure of the Ti layers and the amorphous layers with alternative *** size and volume fraction of the crystalline phases are tuned by Nb *** is found that the ML-BMGCs possess a suitable size and volume fraction of the crystalline phases when Nb microalloying content are5%(at.) or 8%(at.),and they obtain an optimum combination of the specific strength of 243 MPa g kg-1 or 216 MPa g kg-1,and tensile plasticity of 4.33%±0.1 % or 5.10%±0.1%.The deformation mechanism of the as-prepared ML-BMGCs during tension is also *** ex-situ Ti layers and in-situ dendrites together effectively serve as absorbers to suppress the propagation of shear bands and multiply shear *** the defo rmation of ex-situ α-Ti phases by dislocation slip and the transformation from in-situ metastable β-Ti phase to orthorhombic α-Ti during tension impart significant work-hardening capability to the ML-B *** present study provides a guidance of developing novel high-performance BMGCs with a controllable micro structure.