摘要：The effect of hot stamping parameters on the mechanical properties of 22MnB5 steel sheet with thickness of 1.1 mm is studied. The considered parameters are austenization temperature （800- 1 000 ℃ ）, austenitizing soa king time （60-540 s）, initial deformation temperature （560-800 C） and tool temperature （20-220 ℃）. In order to obtain hot stamped parts with optimal mechanical properties, response surface methodology based on the central composite design has been employed to design the experiment matrix. Tensile strength of hot stamped parts is deter- mined as the relation in the mathematical model. The optimal condition and objective effects of parameters are deter mined via this relation. The statistical analysis showed that all four factors significantly affect the tensile strength of the hot stamped parts. The optimum austenization temperature is found to be 918.89 ℃ with the austenitizing soa- king time, initial deformation temperature and tool temperature of 279.45 s, 684.69 C and 21.85 ℃, respectively. These optimal hot stamping parameters prove to have high tensile strength （1 631.84 MPa） where deviation between predicted and actual response falls within 2 %.

摘要：In the current state-of-the-art,high-loss flow in the endwall significantly influences compressor ***,the control of endwall corner separation in compressor blade rows is important to *** on the previous research of the Blended Blade and End Wall(BBEW)technique,which can significantly reduce corner separation,in combination with a nonaxisymmetric endwall,the full-BBEW technique is proposed in this study to further reduce the separation in endwall *** principle of the unchanged axial passage area is considered to derive the geometric method for this *** models are further classified based on different geometric characteristics of this technique:the BBEW model,Inclining-Only End Wall(IOEW)model,and full-BBEW *** most effective design of each model is then found by performing several optimizations at the design point and related numerical investigations over the entire operational *** with the prototype,the total pressure loss coefficient decreases by 7%–9%in the optimized full-BBEW at the design ***,the aerodynamic blockage coefficient over the entire operational range decreases more than the other models,which shows its positive effect for *** approach has a larger decrease at negative incidence angles where the intersection of the boundary layer plays an important role in corner *** analysis shows that the blended blade profile enlarges the dihedral angle and creates a span-wise pressure gradient to move low momentum fluid towards the ***,the inclining hub geometry accelerates the accumulated flow in the corner downstream by increasing the pressure ***,though losses in the mainstream grow,especially for large incidences,the full-BBEW technique effectively reduces the separation in corners.

摘要：Large-scale 3D physical models of complex structures can be used to simulate hydrocarbon exploration areas. The high-fidelity simulation of actual structures poses challenges to model building and quality control. Such models can be used to collect wideazimuth, multi-azimuth, and full-azimuth seismic data that can be used to verify various 3D processing and interpretation methods. Faced with nonideal imaging problems owing to the extensive complex surface conditions and subsurface structures in the oil-rich foreland basins of western China, we designed and built the KS physical model based on the complex subsurface structure. This is the largest and most complex 3D physical model built to date. The physical modeling technology advancements mainly involve 1） the model design method, 2） the model casting flow, and 3） data acquisition. A 3D velocity model of the physical model was obtained for the first time, and the model building precision was quantitatively analyzed. The absolute error was less than 3 mm, which satisfies the experimental requirements. The 3D velocity model obtained from 3D measurements of the model layers is the basis for testing various imaging methods. Furthermore, the model is considered a standard in seismic physical modeling technology.

摘要：Summary of main observation and conclusion Macrocycle has attracted the attention of many researchers in the field of medicinal chemistry due to its unique advantages and good prospects,but the difficulties in drug design and synthesis of macrocycle limit its *** this study,a series of macrocyclic derivatives designed from anaplastic lymphoma kinase(ALK)inhibitor lorlatinib were synthesized as Janus kinase 2(JAK2)selective *** them,17f had the best inhibitory activity(IC50=0.177μmol·L^-1)and selectivity for JAK2 over JAK1 and JAK3,which indicated that design of the macrocyclic derivatives might be a feasible strategy for the discovery of novel selective JAK2 inhihitors.

摘要：Dipeptidyl peptidase 4(DPP-4)is a clinically validated target for the treatment of type 2 diabetes mellitus(T2DM).To discover novel and potent DPP-4 inhibitors,three series of compounds were designed and synthesized in this study based on our previously identified novel scaffold of 2-phenyl-3,4-dihydro-2H-benzo[f]*** the designed compounds,41d-1 was the most po tent one with an IC_(50) value of 16.00 nM.

摘要：分析了模块化动力刀架刀盘形式、刀具驱动接口等关键技术。采用同步带和锥齿轮机构设计了径向模块化动力刀架,利用多级齿轮机构设计了轴向模块化动力刀架。设计了用于控制刀架锁紧和动力模块离合的液压系统。选择了带编码器的伺服电机及接近开关等主要电气部件,规划了工作循环方式,绘制了电气系统的连线图。分别制造了径向模块化动力刀架和轴向模块化动力刀架的样机。