摘要：基于分形几何与复合左右手传输线的混合技术方法,提出了一种新型小型化微带双工器并对其进行了研究。该双工器将工作于一对不同频率的两个三端口网络进行合成,由构成其左手部分的集总元件和右手部分的Sier-pinski分形微带线组成。双工器的小型化得益于Sierpinski分形曲线的空间填充特性。而双工器的双频特性是由于复合左右手传输线具有双曲色散关系。为验证所提方法的有效性,成功设计了基于不同Sierpinski迭代次数的双工器。为证实仿真结果,加工测试了基于Sierpinski二次迭代分形的复合左右手双工器。仿真结果与测试结构吻合的很好。与未采用分形结构的传统复合左右手双工器相比,所制作的双工器工作于GSM两个频段(0.9和1.8 GHz)并获得了良好的通带性能和小型化比例,最大小型化比例达76.3%。

摘要：Recently the content centric networks(CCNs) have been advocated as a new solution to design future networks. In the CCNs, content and its interest are delivered over the content store and pending interest table, respectively, where both have limited capacities. Therefore, how to design the corresponding algorithms to efficiently deliver content and inertest over them becomes an important issue. In this paper, based on the analysis of content distribution, status of content store, and pending interest, we propose a novel caching algorithm with which the resources of content store and pending interest table can be efficiently used. Simulation results prove that the proposal can outperform the conventional methods.

摘要：Since sulfonylurea is one of the most potent acetohydroxyacid synthase（AHAS） inhibitors, a series of novel sulfonylureas containing an oxime ether moiety was designed and synthesized and their chemical structures were determined by means of 1H nuclear magnetic resonance（NMR）, 13C NMR and high-resolution mass spectrometry（HRMS）. In the herbicidal bioassay, several compounds showed moderate to good herbicidal activities against dicotyledons, but their activities against monocotyledons decreased. The in vitro antifungal activity was tested at a dosage of 50 mg/L. And the results show that compounds 71, 7m and 7n exhibit promising antifungal activities against six common plant pathogenic fungi. Further investigations on molecular modification are in progress.

摘要：From stable carbon isotope analysis of tree-rings of Chinese pine (Pinus tabulaeformis) from Mt. Helan, china, we found that high-δ13C values were related to high mean temperatures from June to August (T 68), and Iow-δ13C values corresponded to low T 68. From these data, a transfer function has been used to reconstruct summer temperatures (T 68) for the Mt. Helan region. The explained variance of reconstruction is 34.9% (F=15.01, p<0.001). The time period containing the highest summer temperatures in northern china (late 1920-1930s) was confirmed by our reconstruction. The data indicate that there is a tele-connection between summer temperatures in Mt. Helan area and sea-surface-temperatures in the tropical Pacific. The extreme low temperature periods around the years of 1920 and 1947 for Mt. Helan region correspond well to the cold climate in the tropical Pacific. Along with other analyses, this suggests that climate variations in the Mt. Helan region are driven not only by local events, but also by the global climate. Significant periodicities appearing in the reconstruction are 2.56 and 2.63 years.

摘要：Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response and low response ***,RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties,owing to the ability to efficiently construct hydrogel precursors with well-defined structure,such as block copolymer,graft copolymer,star *** this review,we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.

摘要：The therapeutic application of deoxypodophyllotoxin(DPT) is limited due to its poor water solubility and stability. In the present study, the micelles assembled by the amphiphilic block copolymers(m PEG-PDLLA) were constructed to improve the solubility and safety of DPT for their in vitro and in vivo application. The central composite design was utilized to develop the optimal formulation composed of 1221.41 mg m PEG-PDLLA, the weight ratio of 1 : 4(m PEG-PDLLA : DPT), 30 m L hydration volume and the hydration temperature at 40 oC. The results showed that the micelles exhibited uniformly spherical shape with the diameter of 20 nm. The drug-loading and entrapment efficiency of deoxypodophyllotoxin-polymeric micelles(DPT-PM) were about(20 ± 2.84)% and(98 ± 0.79)%, respectively, indicating that the mathematical models predicted well for the results. Compared to the free DPT, the cytotoxicity showed that blank micelles possessed great safety for Hela cells. In addition, the DPT loaded micelle formulation achieved stronger cytotoxicity at the concentration of 1 × 10^(-7) mol·L^(-1), which showed significant difference from free DPT(P < 0.05). In conclusion, the micelles were highly promising nano-carriers for the anti-tumor therapy with DPT.

摘要：We develop here a simple wet chemistry to prepare covalent functionalized graphenes （FGs） through epoxide aminolysis espe- cially under alkaline aqueous condition. Remarkably, a series of typical monoamines, such as industrial Huntsman Jeffamine M-2070 and M-2005 polymer with hydrophilic or hydrophobic polyetheramine chains, positively-charged 2-amino-N,N,N- trimethylpropanaminium, negatively-charged sulfanilic acid, even oligopeptide sequence, can be effectively grafted on the platelets of graphene oxide precursor with covalent functionalization and partially reduced features. This strategy provides the researchers a facile and convenient approach to design and synthesize solution processable, biocompatible and functionalized graphenes for the potent applications in electronic inks, drug carriers and biomedicines. Expansion of the current study is actively ongoing in our laboratory.

摘要：A gas cluster ion beam（GCIB） system with cluster energy up to 12 keV has been designed. To facilitate pumping of the nozzle chamber and increased pressure of the gas source up to 10 atm, pulse mode was used for the gas feeding. Argon was employed as the working gas. To separate monomers from clusters, both electromagnet and retarding electrode were utilized. A maximal pulsed cluster current of 90 nA has been achieved. The shape of pulsed ion beam currents has been analyzed in detail at different applied magnetic and retarding electric fields.

摘要：Recently, engineered minichromosomes have been produced using a telomere-mediated truncation technique in some plants. However, the study on transferring genes to minichromosomes is very ***, telomere-mediated truncation was successfully performed in common wheat（Triticum aestivum）to generate stable truncated chromosomes accompanied by a relatively high frequency of chromosomal rearrangements. After the cross between transgenic parents, a promoter-less DsRed gene in a chromosome from one parent was transferred to another chromosome from the other parent at the site behind a maize ubiquitin promoter via the Cre/lox system. DsRed transcripts and red fluorescent proteins were detected in the recombinant plants. In one such seedling, transgenic signals were detected at the centric terminus of chromosome 4D and the distal terminus of chromosome 3A. Clear translocations could be detected at the transgenic loci of these two chromosomes. Intriguingly, signals of centric-specific sequences were co-localized with the translocated D-group chromosomal segment in the terminal region of chromosome 3A. Our results indicate that the Cre/lox system induces the gene swapping to the target chromosome and non-homologous chromosomal recombination simultaneously. These approaches could offer a platform to transfer large DNA fragments or even terminal chromosomal segments to other chromosomes of the natural genome.

摘要：Sodium taurocholate cotransporting polypeptide(NTCP)is identified as the functional receptor for HBV entry,which is responsible for upregulated HBV transcription in the HBV life ***,NTCP is also implicated in the progression of HBV-induced hepatocellular carcinoma(HCC).Thereby,NTCP-targeting entry inhibitors are proposed to suppress HBV infection and replication in HBV-induced hepatoma ***,we integrated in silico screening and chemical synthesis to obtain a small-molecule NTCP inhibitor B7,which exhibited moderate anti-proliferative activities against HepG2 cells and anti-HBV activity in ***,CETSA assay,molecular docking,and MD simulation validated that B7 could bind to ***,western blot analysis demonstrated that B7 induced apoptosis with an increased expression of Bax and caspase 3 cleaving as well as a decreasing expression of Bcl-2 in HepG2 *** together,our study identified B7 as a novel NTCP inhibitor with anti-proliferation activities which might provide a new opportunity for HCC therapy.