摘要：The past decade has witnessed a surge of interest in exploring emergent particles in condensed matter *** particles,emerged as excitations around exotic band degeneracy points,continue to be reported in real materials and artificially engineered systems,but so far,we do not have a complete picture on all possible types of particles that can be ***,via systematic symmetry analysis and modeling,we accomplish a complete list of all possible particles in time-reversal-invariant *** includes both spinful particles such as electron quasiparticles in solids,and spinless particles such as phonons or even excitations in electric-circuit and mechanical *** establish detailed correspondence between the particle,the symmetry condition,the effective model,and the topological *** obtained encyclopedia concludes the search for novel emergent particles and provides concrete guidance to achieve them in physical systems.

摘要：Layered inorganic materials provide an essential platform for constructing new structural configurations of materials with exceptional ***,precise control over the interlayer molecular arrangement remains a significant challenge,impeding in-depth exploration in physics and chemistry ***,we demonstrated a new layered organic-inorganic superlattice composed of a S-Ta-S inorganic lattice and bilayer linear molecules,providing superhigh heat insulation.A series of interlayer-confined intercalations of alkylamines with increasing chain length in the layered inorganic materials were achieved through precisely ordered molecule design(TaS_(2)-Cn,n=3,6,8,12).Systematic spectral analysis reveals that as the length of the intercalated alkyl chain increases,the alkyl chain between layers becomes more ordered and linear,and the gauche conformation ***,the more linear and ordered alkyl chain conformation results in lower thermal *** thermal conductivity of TaS_(2)-C12 is 0.426 W m^(−1) K^(−1),which is only one-third that of the pristine TaS_(2) *** anticipate that this layered organic-inorganic superlattice design will pave a new avenue for developing new organic-inorganic functional materials and probing the limits of ultralow thermal conductivity materials.

摘要：Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity,biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres(CuO@CNSs)with doxorubicin hydrochloride(DOX)loading were *** as photothermal agents were synthesized by a hydrothermal *** was adsorbed on the surface of CNSs,which improved the photothermal conversion efficiency due to the electron transitions between C-2 p and Cu-3 *** addition,CuO would release Cu2+ions in the tumor microenvironment,which could produce hydroxyl radical(·OH)to induce cancer cells apoptosis via Haber-Weiss and Fenton-like *** as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer *** CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy(PTT),chemodynamic therapy(CDT),and chemotherapy(CT),which have strong potential for cancer treatment.

摘要：Amidst the development of photoelectrochemical(PEC)CO_(2) conversion toward practical application,the production of high-value chemicals beyond C1 compounds under mild conditions is greatly desired yet ***,through rational PEC device design by combining Au-loaded and N-doped TiO_(2) plate nanoarray photoanode with Zn-doped Cu_(2)O dark cathode,efficient conversion of CO_(2) to CH3COOH has been achieved with an outstanding Faradaic efficiency up to 58.1%(91.5%carbon selectivity)at 0.5 V ***/*** programmed desorption and in situ Raman spectra reveal that the Zn-dopant in Cu_(2)O plays multiple roles in selective catalytic CO_(2) conversion,including local electronic structure manipulation and active site modification,which together promote the formation of intermediate*CH2/*CH3 for C-C *** from that,it is also unveiled that the sufficient electron density provided by the Au-loaded and N-doped TiO_(2) plate nanoarray photoanode plays an equally important role by initiating multi-electron CO_(2) *** work provides fresh insights into the PEC system design to reach the multi-electron reduction reaction and facilitate the C-C coupling reaction toward high-value multicarbon(C2+)chemical production via CO_(2) conversion.

摘要：新型冠状病毒感染引起的新冠肺炎传播已经导致了全世界数百万人的死亡。因此,深入了解新冠病毒的生物学基础对研发控制其传播的新手段至关重要。新冠病毒的核衣壳蛋白(N蛋白)是一个重要的诊断和治疗靶点,它在病毒生命周期中具有多种重要功能。目前已有多个关于新冠病毒N蛋白的结构与功能方面的研究报道。本综述总结了这个进化上高度保守的N蛋白的最新数据,以期提供有关该蛋白的结构和多种功能特征的全面信息。

摘要：The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent *** this work,a nanoplatform for chemo-photothermal therapy with targeting ligand was *** porous structured silica nanotubes(SNTs)with controllable lengths decorated with CuS nanoparticles(NPs)on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell *** with average lengths of 40,55 and 150 nm were obtained and further functionalized as drug *** smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 *** release of doxorubicin hydrochloride(DOX)from the SNTs was dependent on the p H of the buffer solution and 808-nm near infrared(NIR)light *** integration of photothermal therapy(PTT)of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in *** results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.

摘要：通过拨动细胞实现遗传物质的移动,并在对卵母细胞的拨动机理进行深入分析的基础上,根据极体是否可见将卵母细胞的自动拨动过程分为翻动和转动两部分。进一步的,对翻动过程中的卵母细胞进行建模,并通过实验首次提出并实现了四种卵母细胞的自动拨动轨迹。随后,对影响卵母细胞翻动幅度的因素进行了研究,并通过实验证实翻动的幅度可以通过拨动微针的离焦高度进行控制。最后,绵羊的大批量核移植操作应用结果表明,使用设计的自动拨动轨迹的移动遗传物质的成功率可达95%以上。同时,拨动过程中极体出现的位置也和本文提出的翻动模型计算的结果一致,从而验证了本文工作的有效性。

摘要：Tandem electrocatalysis is an emerging concept for effective electrochemical CO_(2) reduction reaction(CO_(2)RR)towards multicarbons(C_(2+)).This decouples the multiple steps of CO_(2)-to-C_(2+)into two steps of CO_(2)-to-CO and CO-to-C_(2+)catalyzed by individual catalysts,to improve the Faradic efficiency(FE).However,due to the mass-transport limitation of CO from the generation site to the long-distance consumption site,such a strategy still remains challenge for high-rate production of C_(2+)***,we designed CuO/Ni single atoms tandem catalyst,which made the catalytic sites of Ni and Cu for independently catalyzing CO_(2)-to-CO and CO-to-C_(2+)compactly neighbored,enabling the in-situ generation and rapid consumption of *** CuO/Ni SAs tandem catalyst achieved a particularly high partial current density of C_(2+)products(1220.8 mA/cm^(2)),while still maintained outstanding C_(2+)products FE(81.4%)and excellent selectivities towards ethylene(FE 54.1%)and ethanol(FE 28.8%),enabling the profitable production of multicarbons by CO_(2)RR.

摘要：临床上常用的广谱抗生素无法有效解决抗生素高度耐药ESKAPE菌感染的难题,ESKAPE耐药菌已经成为人类生命健康的重大威胁.抗生素与佐剂的联合治疗是解决抗生素耐药菌感染的重要途径,但是探索对所有ESKAPE耐药菌都具有广谱和高效抗菌活性的抗生素-佐剂组合仍然面临巨大挑战.在这里,我们提出了一种抗生素-佐剂的有效设计策略,将对ESKAPE中耐药阴性菌具有高活性的多粘菌素B(PMB)与模拟宿主防御肽的细菌膜靶向阳离子聚(2-噁唑啉)相结合.我们通过2-噁唑啉单体可控聚合,合成了一系列具有不同疏水性侧链的阳离子聚(2-噁唑啉).研究表明,聚(2-噁唑啉)和PMB的组合效果随着聚(2-噁唑啉)侧链疏水性的提高呈现出从拮抗效应到协同效应的逐渐变化.其中,优选的聚(2-噁唑啉)EACA-POX_(20)显著增强了PMB的抗菌活性,尤其是对于ESKAPE耐药阳性菌的抗菌活性增强了16–32倍.聚(2-噁唑啉)EACA-POX_(20)有效增强了PMB的抗菌活性并扩展了PMB的抗菌谱.聚(2-噁唑啉)和PMB的组合策略能够有效对抗所有耐药ESKAPE病原体,为解决ESKAPE耐药菌提供了新的思路.

摘要：[Objective] To introduce a convenient and easy way for the statistical anal- ysis on field efficacy trials of pesticide by using Visual Basic. [Method] The calcula- tion procedure of using Visual Basic to conduct statistical analysis on the field efficacy of pesticides was introduced, and an example was used to illustrate the usage and skill of the program. [Result] The procedure could quickly and accurately con- duct statistical analysis on the field efficacy of pesticide by only inputting initial data of the test, and it could compare the significance of differences between various fac- tors. Its calculated results were consistent with the results of the specialized statisti- cal software DPS. [Conclusion] It is a quick and simple method with high accuracy and reliability, which can greatly improve the efficiency of pesticide formulation opti- mization.