摘要：Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous ***,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body ***,inflammation of the wound area can dramatically worsen in response to bacterial *** consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of ***,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto *** encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive ***,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat *** to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain *** approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

摘要：The modular design technology is of importance increasingly,as product structure is more and more *** design systems face challenging problems as the design information tends to be dynamic,redundant,and very *** paper describes a novel approach for handling *** this approach,a partition is firstly performed for the complex structural components by mapping functions to the structures layer by *** on this partition,a comprehensive design matrix is then developed to identify the key design mode which is driven by a special *** design process is also programmed by analyzing the coupled information on both the functional and structural ***,the integrated knowledge model based on object-oriented method and hybrid inference method is *** this model,knowledge can be organized at hierarchical classification and expressed with different ***,the methodology developed has been applied to a real application in automobile cylinder block design and the results are presented.

摘要：High-steep slope stability and its optimal excavation design in Shuichang open pit iron mine were analyzed based on a large 3D physical simulation technique. An optimal excavation scheme with a relatively steeper slope angle was successfully implemented at the northwest wall between Nos. 4 and 5 exploration lines of Shuichang Iron Mine, taking into account the 3D scale effect. The phys-ico-mechanical properties of rock materials were obtained by laboratory tests conducted on sample cores from exploration drilling directly from the iron mine. A porous rock-like composite material was formed for the model, and the mechanical parameters of the material were assessed experimentally;specifically, the effect of water on the sample was quantitatively determined. We adopted an experimental setup using stiff modular applied static loading to carry out a visual excavation of the slope at a random depth. The setup was equipped with acous-tic emission （AE） sensors, and the experiments were monitored by crack optical acquirement, ground penetrating radar, and close-field pho-togrammetry to investigate the mechanisms of rock-mass destabilization in the high-steep slope. For the complex study area, the model re-sults indicated a clear correlation between the model＇s destabilization resulting from slope excavation and the collected monitoring informa-tion. During the model simulation, the overall angle of the slope increased by 1-6 degrees in different sections. Dramatically, the modeled excavation scheme saved over 80 million tons of rock from extraction, generating enormous economic and ecological benefits.

摘要：Based on angular amplitude modulation of orthogonal base vectors in common-path interference method, we propose an interesting type of hybrid vector beams with unprecedented azimuthal polarization gradient and demonstrate in experiment. Geometrically, the configured azimuthal polarization gradient is indicated by intriguing mapping tracks of angular polarization states on Poincaré sphere, more than just conventional circles for previously reported vector beams. Moreover, via tailoring relevant parameters, more special polarization mapping tracks can be handily achieved. More noteworthily, the designed azimuthal polarization gradients are found to be able to induce azimuthally non-uniform orbital angular momentum density, while generally uniform for circle-track cases, immersing in homogenous intensity background whatever base states are. These peculiar features may open alternative routes for new optical effects and applications.

摘要：射频离子阱作为离子捕获系统的核心器件,广泛应用于化学反应动力学、原子分子物理、精密测量和离子光谱等领域.离子阱可以与低温制冷机相结合,将离子储存、富集并冷却至低温,从而为后续实验提供极大便利,例如高分辨光谱学。本文详细描述了一种射频线电极四极杆离子阱的结构设计,该离子阱利用六个线电极作为传统四极杆离子阱的一个圆柱形电极模拟双曲面.研究模拟了离子阱内的电场分布和离子运动轨迹,用以考察所设计的射频线电极四极杆离子阱的性能,研究表明它能够将离子囚禁束缚在一个很小的空间.基于所设计的离子阱支撑部件、离子阱腔体、电极和印刷电路板,结合所选择的材料进行了传热学模拟。模拟的温度分布表明,所设计的射频线电极四极杆离子阱与液氢低温制冷机结合使用,可以将离子冷却到5K以下的低温.这项工作将有助于推动离子阱技术在精密光谱学中的应用。

摘要：为了研究基于微光纤的谐振器中的慢光效应,设计并制作了并联结构的微光纤双结谐振器.基于环形谐振器和方向耦合器理论,提出并联结构微光纤双结谐振器的理论模型,分析了该谐振器中光场传输和耦合的方向,推导了该谐振器中输出光场与输入光场之间的数学解析式和群延时表达式.通过数值模拟,给出了有关该谐振器的透射光谱和群延时,分析了群延时与透射光谱中谐振波长的对应关系.数值结果表明在该谐振器中,大的群延时能够在具有大消光比的谐振波长处产生.实验制作了一个并联结构的微光纤双结谐振器,测得的透射光谱与理论模拟相一致,验证了该谐振器理论分析的正确性.利用示波器上脉冲延时的方法,搭建了慢光延时测量系统,测得该谐振器中大约75ps的群延时,远大于现有文献中的值.该谐振器可用于微纳光学的数据延时线、光学开关和光学存储等.

摘要：Regulation of osteogenic differentiation of bone mesenchymal stromal cells （BMSCs） plays a critical role in bone regeneration. As small non-coding RNAs, microRNAs （miRNAs） play an important role in stem cell differentiation through regulating target-mRNA expression. Unfortunately, highly efficient and safe delivery of miRNAs to BMSCs to regulate their osteogenic differentiation remains challenging. Conventional inorganic nanocrystals have shown increased toxicity owing to their larger size precluding renal clearance. Here, we developed novel, surface-engineered, ultra-small gold nanoparticles （USAuNPs, 〈10 nm） for use as highly efficient miR-5106-delivery systems to enable regulation of BMSC differentiation. We exploited the effects of AuNPs coated layer-by-layer with polyethylenimine （PEI） and liposomes （Lipo） to enhance miR-5106-delivery activity and subsequent BMSC differentiation capacity. The PEI- and Lipo-coated AuNPs （Au@PEI@Lipo） showed negligible cytotoxicity, good miRNA-5106-binding affinity, highly efficient delivery of miRNAs to BMSCs, and long-term miRNA expression （21 days）. Additionally, compared with commercial Lipofectamine 3000 and 25 kD PEI, the optimized Au@PEI@Lipo-miR-5106 nanocomplexes significantly enhanced BMSC differentiation into osteoblast-like cells through activation of the Sox9 transcription factor. Our findings reveal a promising strategy for the rational design of ultra-small inorganic nanoparticles as highly efficient miRNA-delivery platforms for tissue regeneration and disease therapy.

摘要：合成了6-((2H-四唑-5-基)-氨基)-1,2,4,5-四嗪-3(2H)-酮(TATzO)并通过红外光谱、元素分析、核磁和单晶X射线衍射对其结构进行了表征。单晶结构表明,TATzO·H2O属于正交晶系,空间群是Pnma,密度为1.730 g·cm-3。在非等温条件下,利用差示扫描量热法(DSC)和热重(TG-DTG)研究了TATzO的热分解行为并计算得到分解峰温、活化能(E)、指前因子(A)、热点火温度(Tbe)和热爆炸临界温度(Tbp),分别为230.46℃、169.03 kJ·mol^-1、15.65 s^-1、213.75℃和223.03℃。TATzO·H2O分解峰温和热爆炸临界温度与传统含能材料RDX相近,表明TATzO热稳定性较高。通过高斯03软件包设计等键反应计算生成焓(HOF),由Kamlet-Jacobs(K-J)方程计算爆速(D)和爆压(p)以评估爆轰性能。D和p分别为7757 m·s^-1和25.74 GPa。落锤法测得TATzO撞击感度大于24 J。

摘要：提出了一种基于Globus Toolkit 4的仿真网格系统框架HLA-G,旨在克服传统的基于HLA/RTI的分布式仿真框架存在的安全性、动态集成等方面的缺陷,使HLA技术和网格技术更好地结合在一起。文中给出了HLA-G的体系结构,具体讨论一些关键的设计问题。还给出了一种基于WSRF的RTI设计方案WS-RTI,讨论了HLA联邦成员配置和部署服务的实现方案。最后给出了一个部署模式的例子,分析了仿真任务的提交过程和联邦成员的迁移过程。

摘要：Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of ***,it is still challenging to ensure the integrity,physiological function and regeneration ability of stratified OC scaffolds in clinical *** OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC *** a consequence,the researches on biomimetic design to achieve the tissue function of each layer,and additive manufacture(AM)to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable *** this review,the design methods of biomaterial and structure as well as computer-aided design,and performance prediction of biopolymer-based OC scaffolds are presented;then,the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized;finally,the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.