摘要：本文旨在探讨c-Myc通过调控ATP结合盒(ATP-binding cassette,ABC)转运蛋白表达对CD133^+肠癌干细胞耐药性的影响及机制。以人肠癌HT29细胞系为模型,通过流式细胞分选术获得CD133^+肠癌干细胞,以核心基因c-Myc为靶点设计小干扰RNA(siRNA),靶向抑制CD133^+细胞中c-Myc基因表达;免疫印迹法检测c-Myc沉默后ABC转运蛋白家族成员(ABCG2、MDR-1和ABCB5)表达水平变化;药敏实验检测肠癌干细胞对化疗药物(5-FU或/和奥沙利铂)的耐药性。结果显示,CD133^+细胞高表达核心基因c-Myc,si RNA显著抑制肠癌干细胞中c-Myc的表达水平;CD133^+肠癌干细胞对化疗药物(5-FU或/和奥沙利铂)具有耐药性;si RNA通过抑制c-Myc下调CD133^+肠癌干细胞ABC转运蛋白(ABCG2、MDR-1和ABCB5)的表达水平;靶向抑制c-Myc表达提高CD133^+肠癌干细胞对化疗药物的敏感性(P<0.05)。以上结果表明,c-Myc通过调控ABC转运蛋白表达水平参与肿瘤干细胞的耐药机理,靶向抑制c-Myc能提高CD133^+肠癌干细胞对化疗药物的敏感性。

摘要：提出了一种在150～165 THz区域内的具有单峰吸收特性的高性能超材料吸收器。设计的吸波器包含两个阵列:双金属颗粒阵列和双空气孔阵列。金属层的阻尼常数在模拟中被优化。发现在模拟中使用2. 3倍的阻尼常数时,可以获得最大吸收率96%。吸收峰由局域表面等离子体(LSP)模式共振激发。为了揭示共振电磁机理,进行了两组模拟,研究结构参数变化对共振吸收峰的影响。发现随着垂直距离V的增加,吸收峰被增强,当V=160 nm时,获得新的吸收带。在第二次模拟中,对于水平距离H的增加,吸收峰也增强,并且当H=190 nm时获得另一个新的吸收带。电场强度分布结果表明LSP模式的激发和LSP模式之间的耦合效应导致吸收峰增强现象。

摘要：大型厚壁空心长轴类零件是工业装备中的关键零部件,本研究采用多楔楔横轧成形该类零件。首先,推导多楔楔横轧长轴空心件的侧楔偏转角公式,为多楔楔横轧模具的设计奠定了基础。然后,研究展宽角对单楔楔横轧厚壁空心件的影响规律,发现相对于轧制小直径空心轴,展宽角的选择范围可以扩大,内孔椭圆度也能得到控制。同时发现模具的顶面脱空也能控制内孔椭圆度。最后,建立双楔楔横轧轧制大型厚壁空心长轴类零件的有限元模型,模拟了成形过程,监测对称面的内孔椭圆度,有限元计算的内孔椭圆度为4.98%,轧制实验值为5.56%。结果表明:双楔楔横轧大型厚壁空心长轴类零件是可行的。

摘要：All the progress from design to construction of Xihoumen Bridge project and some technical questions were researched, such as design idea considering topography condition, structure choosing considering wind resist and controlling progression of construction considering complex ocean environment, etc. The key technical innovations reached international advanced level.

摘要：本文构建了含有电光材料LiNbO3的一维对称广义Fibonacci光子晶体结构,提出并设计了一种基于该结构的可调谐滤波器,并利用传输矩阵法对设计的滤波器的可调谐滤波特性进行了理论研究.数据模拟结果表明:保持对称广义Fibonacci光子晶体的几何结构不变,通过改变电极所在处施加在电光介质(LiNbO3)层上的外加电场,即可实现滤波器的滤波通道波长的调节,滤波通道波长的改变与外加电压呈线性关系,随着外加电压的增加,滤波通道波长向短波长方向移动.此外,电压一定时,通道波长随光的入射角的增加向短波长方向移动;光的入射角一定时,外加正电压下,通道波长随电压增加发生蓝移,而外加负电压下,通道波长随反向电压的增加发生红移.最后,讨论了双电场作用下的多通道波长滤波器的结构极其特性.以上结果对于新型光子晶体器件的设计具有重要的参考价值.

摘要：基于表面等离激元受激辐射放大(SPASER)机制,提出了一种硅-金-硅三层核壳偏心纳米天线,并利用有限元法分析了其多波长散射特性.结果表明:在SPASER机制下,该纳米天线产生极大的散射光强度,且工作波长的数目随着硅核偏心率的增加而增加;当硅核的偏心率为9nm时,该纳米天线有4个共振峰,分别位于615nm、656nm、724nm、847nm,其对应的散射强度比非SPASER机制的纳米天线的散射强度高104倍;该纳米天线的散射波长还可以通过改变入射光的偏振角调节.基于SPASER机制的纳米天线对于设计多波长纳米激光器具有指导意义.

摘要：锂金属是下一代高能量密度二次电池的理想负极材料,然而它的应用仍然受制于较差的循环稳定性。近期,二维氟化界面被广泛用于改善锂金属负极的成核机制、沉积形貌和循环稳定性。本工作通过将体积缩小化的氟化石墨颗粒与锂离子传导网络结合,获得了一种富氟化位点的三维框架结构。实验结果证明此类三维氟化结构可显著提升锂金属负极在不同电流密度和容量下的循环稳定性,且优于二维氟化界面结构。通过本工作的研究,证明了相较于单纯的二维氟化界面,三维锂离子传导网络和富氟化位点的合理结合可以成为一种改进的界面结构用于锂金属负极保护,为高能量密度锂金属电池的负极保护提供了新的设计思路。

摘要：Chemical prelithiation is regarded as a crucial method for improving the initial Coulombic efficiency(ICE)of Li-storage ***,a substituent-engineered Li-cyanonaphthalene chemical prelithiation system is designed to simultaneously enhance the ICE and construct a multifunctional interfacial film for SiO electrodes.X-ray photoelectron spectroscopy(XPS),electron energy-loss spectroscopy(EELS),nuclear magnetic resonance(NMR)spectroscopy and atomic force microscopy(AFM)prove that the Licyanonaphthalene prelithiation reagent facilitates the formation of a rectified solid electrolyte interface(SEI)film in two ways:(1)generation of a gradient SEI film with an organic outer layer(dense Ncontaining organics,ROCO_(2)Li)and an inorganic LiF-enriched inner layer;(2)homogenization of the horizontal distribution of the composition,mechanical properties and surface *** a result,the prelithiated SiO electrode exhibits an ICE above 100%,enhanced CEs during cycling,better cycle stability and inhibition of lithium dendrite formation in the overcharged ***,the prelithiated hard carbon/SiO(9:1)‖LHCoO_(2) cell displays an enhancement in the energy density of 62.3%.

摘要：Information storage and corresponding encryption/decryption are highly important owing to the prevalence of counterfeit activities and information leakage in the current age. Herein, we propose a novel method to store information via controllable ionoprinting onto fluorescent hydrogel for hierarchical and multi-dimensional *** incorporating pyrene moieties and carboxylic groups into polymeric hydrogel network, fluorescence changing and controllable shape deformation behaviors could be achieved and integrated by ionoprinting of Fe3+ions. The diffusion of Fe^3+ions into fluorescent hydrogel can quench the fluorescence of pyrene moieties, and chelate with carboxylic groups to generate anisotropic structures for shape deformation simultaneously. Thus, fluorescence quenching-based 2D information and actuation-based 3D information could be hierarchically decrypted when exposed to UV light and being put into water, respectively. Importantly, the stored information could be erased by replacing Fe^3+with H^+, which allows the fluorescent hydrogel as a recyclable information storage material. This work may provide new insights in designing and fabricating novel soft devices for hierarchical and multidimensional information encryption, against the rising problems of counterfeiting and confidential information disclosure.

摘要：The development of inexpensive and efficient Pt-free electrocatalysts for the hydrogen evolution reaction(HER)is greatly crucial for water *** carbide(WC)exhibiting a Pt-like electronic structure represents an attractive alternative,although its overall performance is limited by the strong W-H bond that impedes hydrogen ***,we employed an in-situ interface engineering strategy to construct high-performance and cost effective electrocatalysts comprising WC/tungsten phosphide(WP)heterostructures that were anchored on N,P-codoped carbon(WC/WP@NPC)via a one-step pyrolysis of a melamine polyphosphate/WO_(3) hybrid in an inert *** to the crystal structure compatibility and electron-rich property of WP,it optimizes the electronic structure and hydrogen adsorption configuration of WC,thus significantly weakening the W-H bond with a thermoneutral Gibbs free energy of hydrogen adsorption(ΔG_(H^(*)))of−0.05 ***,NPC ensures fast electron transport and structural stability of the WC/WP@NPC ternary *** synergistically lead to outstanding HER performances of the catalyst in acidic and alkaline *** finding offers a new strategy for designing Pt-alternative electrocatalysts with outstanding electrochemical performances for high-efficiency water splitting and other applications.