摘要：This paper applies genetic simulated annealing algorithm (SAGA) to solving geometric constraint problems. This method makes full use of the advantages of SAGA and can handle under-/over- constraint problems naturally. It has advantages (due to its not being sensitive to the initial values) over the Newton-Raphson method, and its yielding of multiple solutions, is an advantage over other optimal methods for multi-solution constraint system. Our experiments have proved the robustness and efficiency of this method.

摘要：A newly isolated strain EL31410, producing elastase (E.C3.4.4.7) with h igh elastolytic activity was identified as Bacillus sp. In the medium opt imizat ion, it was found that wheat bran and soybean flour hydrosate were the best crud e carbon and nitrogen source for enzyme production, respectively. Addition of co rn steep flour can affect the bacterium growth and elastase production. A fracti onal factorial design was applied to study the main factors that affect the enzy me production, and central composite experimental design and response surface me thodology were adopted to derive a statistical model for the effect of wheat bra n and soybean flour hydrosate on elastase production. The experimental results s howed that wheat bran had positive effect but soybean flour hydrosate had neg ative effect, on enzyme production. An initial concentration of 3.4%(w/v) wh eat b ran and 9.4%(v/v) soybean flour hydrosate were found to be optimal for enzyme pr oduction in batch culture. The time course of elastase production in the optimiz ed medium composition was also described.

摘要：Traditional fractal pattern design has some disadvantages such as inability to effectively reflect the characteristics of real scenery and texture. We propose a novel pattern design technique combining fractal geometry and image texture synthesis to solve these problems. We have improved Wei and Levoy (2000)’s texture synthesis algorithm by first using two-dimensional autocorrelation function to analyze the structure and distribution of textures, and then determining the size of L neighborhood. Several special fractal sets were adopted and HSL (Hue, Saturation, and Light) color space was chosen. The fractal structure was used to manipulate the texture synthesis in HSL color space where the pattern’s color can be adjusted conveniently. Experiments showed that patterns with different styles and different color characteristics can be more efficiently generated using the new technique.

摘要：The goal of the arterial graft design problem is to find an optimal graft built on an occluded artery, which can be mathematically modeled by a fluid based shape optimization problem. The smoothness of the graft is one of the important aspects in the arterial graft design problem since it affects the flow of the blood significantly. As an attractive design tool for this problem, level set methods are quite efficient for obtaining better shape of the graft. In this paper, a cubic spline level set method and a radial basis function level set method are designed to solve the arterial graft design problem. In both approaches, the shape of the arterial graft is implicitly tracked by the zero-level contour of a level set function and a high level of smoothness of the graft is achieved. Numerical results show the efficiency of the algorithms in the arterial graft design.

摘要：By research on the switch-signal theory for multiple-valued logic circuits, the theory of three essential elements and the principle of adiabatic circuits, a design scheme for a double power clock ternary clocked transmission gate adiabatic logic （DTCTGAL） circuit is presented. The energy injection and recovery can be conducted by the bootstrapped NMOSFET, which makes the circuit maintain the characteristics of energy recovery as well as multiple-valued input and output. An XOR/XNOR circuit based on DTCTGAL is also presented using this design scheme. Finally, using the parameters of a TSMC 0.25μm CMOS device, PSPICE simulation results indicate that the proposed circuits have correct logic and significant low power characteristics.

摘要：Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic *** this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic *** methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding *** resultant GelMA-MNs exhibited excellent mechanical properties and moisture ***,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic *** drug release period could be significantly prolonged by improving the cross-link density of *** results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.

摘要：In this paper, thermal characteristics of the high-power LED spot lamp are reported. The emphasis is placed upon optimizing design of the heat sink of LED spot lamp using the optimization module and the orthogonal-experiment method. Results demonstrate that the weight of the heat sink is decreased to 46.1% of that for the initial structure, and the influence of each factor on junction temperature and weight of the heat sink is acquired by range analysis. Finally, the influence of ambient temperature and natural convection coefficient on the LED maximum temperature is analyzed. The results and the optimizing methodology are of great importance to the thermal design of LED lamps.

摘要：In this paper, a new four-dimensional autonomous hyperchaotic system is designed for generating complex chaotic signals. In the design, its parameters are selected according to the requirements for chaos and hyperchaos. The hyperchaotic nature is verified theoretically by using the bifurcation analysis and demonstrated experimentally by the implementation of an analogue electronic circuit. Moreover, the Field Programmable Gate Array （FPGA） technology is applied to implementing a continuous system in a digital form by using a chip of Altera Cyclone II EP2C35F484C8. The digital sequence generated from the FPGA device is observed in our experimental setup.

摘要：Underwater gliders are efficient mobile sensor platforms that can be deployed for months at a time, traveling thousands of kilometers. Here, we describe our development of a coastal 200 m deep underwater glider, which can serve as an ocean observatory platform operating in the East China Sea. Our glider is developed based on dynamic model analysis: steady flight equilibrium analysis gives the varied range of moving mass location for pitch control and the varied vehicle volume for buoyancy control; a stability analysis is made to discuss the relationship between the stability of glider motion and the location of glider wings and rudder by root locus investigation of glider longitudinal- and lateral-directional dynamics, respectively. There is a tradeoff between glider motion stability and control authority according to the specific glider mission requirements. The theoretical analysis provides guidelines for vehicle design, based on which we present the development progress of the zhejiang University (ZJU) glider. The mechanical, electrical, and software design of the glider is discussed in detail. The performances of glider key functional modules are validated by pressure tests individually; preliminary pool trials of the ZJU glider are also introduced, indicating that our glider functions well in water and can serve as a sensor platform for ocean sampling.

摘要：Four-dimensional(4D)printing is an advanced form of three-dimensional(3D)printing with controllable and programmable shape transformation over *** are used as a controlling factor with multi-stage shape recovery,with emerging opportunities to customize the mechanical properties of bio-inspired *** print pattern of shape memory polymer(SMP)fbers strongly afects the achievable resolution,and consequently infuences several other physical and mechanical properties of fabricated ***,the deformations of bio-inspired structures due to actuator layout are more complex because of the presence of the coupling of multi-directional *** this study,the initial structure was designed from closed-shell behavior and divided into a general unit and actuator unit,the latter responsible for driving the *** stress confrontation between the actuator and the general unit was considered in the layout thermodynamic model,in order to eliminate the transformation produced by the uncontrolled shape memory behavior of the general *** critical and efective strategies for the layout design of actuators were proposed and then applied to achieve the desired accurate deformation of 3D-printed bilayer ***,the proposed approach was validated and adopted for fabricating a complex shell-like gripper structure.