摘要：Galloping cheetahs,climbing mountain goats,and load hauling horses all show desirable locomotion capability,which motivates the development of quadruped *** various quadruped robots,hydraulically driven quadruped robots show great potential in unstructured environments due to their discrete landing positions and large *** the most critical movement unit of a quadruped robot,the limb leg unit(LLU)directly affects movement speed and reliability,and requires a compact and lightweight *** by the dexterous skeleton–muscle systems of cheetahs and humans,this paper proposes a highly integrated bionic actuator system for a better dynamic performance of an *** propose that a cylinder barrel with multiple element interfaces and internal smooth channels is realized using metal additive manufacturing,and hybrid lattice structures are introduced into the lightweight design of the piston *** addition,additive manufacturing and topology optimization are incorporated to reduce the redundant material of the structural parts of the *** mechanical properties of the actuator system are verified by numerical simulation and experiments,and the power density of the actuators is far greater than that of cheetah *** mass of the optimized LLU is reduced by 24.5%,and the optimized LLU shows better response time performance when given a step signal,and presents a good trajectory tracking ability with the increase in motion frequency.

摘要：Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical *** has also been employed in various advanced industrial *** development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative ***,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and *** this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D ***,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced ***,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting *** review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue *** paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide ***,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

摘要：对柔性电子设备日益增长的需求使得开发具有高灵敏度和高线性度的传感器更加迫切.由于拉伸应变下不可逆结构损伤诱导电阻线性急剧增加,现有的可拉伸应变传感器难以完美地同时实现这两个特性.针对这一问题,本文提出了一种兼具表面褶皱和体相梯度孔隙的新型分级互连结构,利用水热活化机制精确控制纳米级褶皱间距,通过调控相分离中热力学和动力学行为构筑出体相梯度多孔结构,通过改变器件两侧曲率实现各向异性特征,深入研究各种设计的功效、量化几何结构对灵敏度的有效贡献和追踪形态演变.基于器件显著的灵敏度和各向异性,所制备的传感器能够有效监测静态和动态位移、表面运动、二维应变信号变化以及预测液位随时间变化.本工作为实现高质量的感知能力提供了一种广泛适用、适应性强、可扩展且具有成本效益的方法.

摘要：Four-dimensional(4D)printing is an advanced form of three-dimensional(3D)printing with controllable and programmable shape transformation over *** are used as a controlling factor with multi-stage shape recovery,with emerging opportunities to customize the mechanical properties of bio-inspired *** print pattern of shape memory polymer(SMP)fbers strongly afects the achievable resolution,and consequently infuences several other physical and mechanical properties of fabricated ***,the deformations of bio-inspired structures due to actuator layout are more complex because of the presence of the coupling of multi-directional *** this study,the initial structure was designed from closed-shell behavior and divided into a general unit and actuator unit,the latter responsible for driving the *** stress confrontation between the actuator and the general unit was considered in the layout thermodynamic model,in order to eliminate the transformation produced by the uncontrolled shape memory behavior of the general *** critical and efective strategies for the layout design of actuators were proposed and then applied to achieve the desired accurate deformation of 3D-printed bilayer ***,the proposed approach was validated and adopted for fabricating a complex shell-like gripper structure.

摘要：Sensitivity analysis is used to quantify the contribution of the uncertainty of input variables to the uncertainty of systematic output *** tolerance design in manufacturing and assembly,sensitivity analysis is applied to help designers allocate tolerances ***,different sensitivity indices derived from different sensitivity analysis methods will always lead to conflicting *** is necessary to find a sensitivity index suitable for tolerance allocation to transmission mechanisms so that the sensitivity results can truly reflect the effects of tolerances on kinematic and dynamic *** this paper,a variety of sensitivity indices are investigated and compared based on hybrid ***,the hybrid simulation model of the crank-slider mechanism is ***,samples of the kinematic and dynamic responses of the mechanism with joint clearances and link length errors are obtained,and the surrogate model established using polynomial chaos expansion(PCE).Then,different sensitivity indices are calculated based on the PCE model and are further used to evaluate the effect of joint clearances and link length errors on the output *** with the tolerance-cost function,the corresponding tolerance allocation schemes are obtained based on different sensitivity analysis ***,the kinematic and dynamic responses of the mechanism adopting different tolerance allocation schemes are simulated,and the sensitivity index corresponding to the optimal response is determined as the most appropriate index.

摘要：Sweat,as a biofluid with the potential for noninvasive collection,provides profound insights into human health conditions,because it contains various chemicals and information to be utilized for the monitoring of well-being,stress levels,exercise,and ***,wearable sweat sensors have been developed as a promising substitute to conventional laboratory sweat detection *** sensors are promising to realize low-cost,real-time,in situ sweat measurements,and provide great opportunities for health status evaluation analysis based on personalized big *** review first presents an overview of wearable sweat sensors from the perspective of basic components,including materials and structures for specific sensing applications and *** strategies and specific methods of the fabrication of wearable power management are also ***,current challenges and future directions of wearable sweat sensors are discussed.

摘要：Prosthesis implantation and fat transplantation are common breast *** general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct *** date,no reports have focused on methods of combining fat with implanted prostheses for breast *** a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous *** was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external *** compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural ***,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose *** were implanted subcutaneously in nude mice to observe their biological *** 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the *** result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.

摘要：Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on ***,we propose a novel strategy combining benidipine,an antihypertensive drug and nanoparticles to synergistically promote the healing of bone *** and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their *** nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the *** internalization into cells,the nanosystem is degraded by lysosomes,and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine,silicon and magnesium *** results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts,indicating that it might be a potential approach in guiding bone repair in clinical applications.

摘要：Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic ***,current organ-on-a-chip platforms are limited by a“single pot”design,which inevitably requires holistic analysis and limits parallel ***,we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres,which significantly increased the parallelism over traditional organ-on-a-chip for drug *** to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units,allowing for analysis with high consistency and quick *** platform displayed evident anti-cancer efficacy at a concentration of 10μM for sorafenib,and had greater alignment than the“single pot”organ-on-a-chip with a previous in vivo *** addition,this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50μg/*** successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities,thereby accelerating the joint endeavor to combat cancer.

摘要：设计和制备用于高效氧还原反应(ORR)的非贵金属基电催化剂对于清洁能源转换装置的开发至关重要,但又极具挑战性.在本工作中,我们通过热解双金属前驱体ZIF-Zn/Co,成功制备了一种新型的分级中空碳纳米复合材料HNCT-CNT.该材料富含Co-Nx位点以及原位形成的多壁碳纳米管.理论和实验表明, HNCT-CNT使ORR中间体的活化能垒降低,因而表现出了优异的ORR性能.最佳催化剂表现出较正的半波电位为0.85 V,极限电流密度高达6.36 mA cm^(-2), Tafel斜率为58.2 mV dec^(-1),且结构稳定性良好.此外,基于HNCT-CNT组装的锌空气电池还显示出1.49 V的开路电压和116.56 mW cm^(-2)的功率密度.综上,这种无机物模板法为制备金属有机框架化合物衍生的非贵金属基碳纳米电催化剂用于高效的电化学能源领域提供了一种新的方法.