摘要：Background Chronic obstructive pulmonary disease(COPD)is a severe public health *** smoke(CS)is a risk factor for COPD and lung *** underlying molecular mechanisms of CS-induced malignant transformation of bronchial epithelial cells remain *** this study,we describe a lung-on-a-chip to explore the possible mechanistic link between cigarette smoke extract(CSE)-associated COPD and lung *** An in vitro lung-on-a-chip model was used to simulate pulmonary epithelial cells and vascular endothelial cells with *** levels of IL-6 and TNF-αwere tested as indicators of inflammation using an enzyme-linked immune sorbent *** junction complex mRNA expression was detected with qRT-PCR as the index of epithelial-to-mesenchymal transition(EMT).The effects of CSE on the phosphorylation of signal transduction and transcriptional activator 3(STAT3)were detected by Western *** cytometry was performed to investigate the effects of this proto-oncogene on cell cycle *** Inflammation caused by CSE was achieved in a lung-on-a-chip model with a mimetic *** exposure induced the degradation of intercellular connections and triggered the EMT *** exposure also activated the phosphorylation of proto-oncogene STAT3,while these effects were inhibited with *** CSE exposure in the lung-on-a-chip model caused activation of STAT3 in epithelial cells and endothelial ***0152,an inhibitor of activated STAT3,could be a potential treatment for CS-associated COPD and lung cancer.

摘要：Natural anisotropic nanostructures occurring in several organisms have gained more and more attention because of their obvious advantages in sensitivity, stability, security, miniaturization, portability, online use, and remote monitoring. Due to the development of research on nature-inspired bionic structures and the demand for highly efficient, low-cost microfabrication techniques, an understanding of and the ability to replicate the mechanism of structural coloration have become increasingly significant. These sophisticated structures have many unique functions and are used in many applications. Many sensors have been proposed based on their novel structures and unique optical properties. Several of these bio-inspired sensors have been used for infrared radiation/thermal, pH, and vapor techniques, among others, and have been discussed in detail, with an intense focus on several biomedical applications. However, many applications have yet to be discovered. In this review, we will describe these nanostructured materials based on their sources in nature and various structures, such as layered, hierarchical, and helical structures. In addition, we discuss the functions endowed by these structures, such as superhydrophobicity, adhesion, and high strength, enabling them to be employed in a number of applications in biomedical fields, including cell cultivation, biosensors, and tissue engineering.

摘要：A 40-60 t/h modularized dry coal beneficiation process with a novel method to control the bed was designed around a gas-solid fluidized bed separator. Furthermore, the hydrodynamics of medium-solids consisting of wide-size-range magnetite powder （0.3-0.06 ram） and 〈1 mm fine coal were numerically studied. The simulation results show that the fluidization performance of the wide-size-range medium-solid bed is good. The separation performance of the modularized system was then investigated in detail using a mixture of 〈0.3 mm magnetite powder （mass fraction of 0.3-0.06 mm particles is 91.38 %） and 〈1 mm fine coal as solid media. The experimental results show that at separation densities of 1.33 g/cm^3 or 1.61 g/cm^3, 50-6 mm coal can be separated effectively with probable error, E, values of 0.05 g/cm^3 and 0.06 g/cm^3, respectively. This technique is beneficial for saving water resources and for the clean utilization of coal.

摘要：The novel jet self-priming centrifugal pump,as important modern irrigation equipment,is widely used in large-scale irrigation,mine drainage and so *** order to improve the profile streamline of blade,the inlet shape of impeller was designed as distorted and the outlet shape as cylindrical,which can not only improve the pump efficiency,but also shorten the self-priming ***,the novel jet self-priming system was proposed,by employing the jet nozzle and check valve to improve the velocity of ***,nine different structure jet nozzles were designed based on the orthogonal design method,and the relevant self-priming experiments were performed on I level accuracy test bench in jiangsu *** to the greycorrelational analysis,the influence of the nozzle geometry parameters on the self-priming performance was *** relationship between self-priming time and self-priming height was *** test results showed that the hydraulic design of jet self-priming centrifugal pump was reasonable;all indicators met the Chinese national standard;the head reached 21.04 m and efficiency was 72.8%under the design flow *** is more,the self-priming performance was obviously improved by adjusting the geometrical parameters of *** the height of the self-priming process was 5.3 m,the self-priming time reached 62 s,which was much shorter than the national ***,this research could provide reference for designing the structure of jet self-priming centrifugal pump.

摘要：在水稻脱粒过程中,脱粒滚筒的转速、凹板间隙、齿间距等是脱粒籽粒损失率和脱粒功耗的重要影响因素。为获得水稻联合收割机上纵轴流脱粒滚筒的最佳脱粒参数组合及可控范围,在自行研制的切纵流脱粒分离试验台上开展了水稻脱粒分离性能试验研究。对纵轴流滚筒在不同脱粒滚筒转速、凹板间隙、齿间距参数组合下进行水稻脱粒性能台架试验研究,并对试验结果进行回归分析和置信度分析。将获得的最佳操作参数置信区间用于控制纵轴流滚筒的水稻脱粒性能并预测其最优参数组合,同时进行了验证。结果表明,为将纵轴流脱粒滚筒的总损失率控制在0.33%以内且将脱粒功耗控制在46.36 k W以内,则具有95%置信度的纵轴流滚筒转速为772.61～905.74 r/min、脱粒间隙为22.18～37.93mm、齿间距为104.96～170.17 mm,其相应的纵轴流滚筒最佳转速为839r/min、凹板间隙为30 mm、齿间距为138 mm。该研究对于降低纵轴流滚筒的脱粒功耗和籽粒损失具有重要意义,同时可为水稻联合收割机纵轴流脱粒滚筒最佳结构及参数设计提供参考。

摘要：The aim of the present study is to detect the potential of the base population from diallel crosses of eight introduced strains of the Pacific white shrimp（Litopenaeus vannamei） for improving the yield. Heterosis and heritability were estimated for pond survival at commercial farm conditions for the base population that included 207 full-sib families from a nested mating design by artificial insemination. Among all the hybrids,the heterosis ranged from –11.37%（UA1×UA2） to 20.53%（UA3×SIN） with an average of 0.953%. The results showed that more than half of the hybrids（51.85%） have negative heterosis for survival rate, but most of the hybrids with positive heterosis have high estimates. The high proportion of negative heterosis for survival rate reminders us that the survival trait also should be considered in the crossbreeding program to avoid yield decrease. However, high positive heterosis manifested in most of the hybrids for survival indicates the usefulness of these hybrids for improving the survival to obtain higher yield by crossbreeding in this breeding program. The heritability estimate for pond survival was 0.092±0.043 when genetic groups were included in the pedigree, and it was significantly different from zero（P〈0.05）. The results from this study also indicated that significant improvement for survival is possible through selection in L. vannamei.

摘要：To promote the performance of the traditional multichannel filter bank which leads to speech quality degradation,an efficient design method of the non-uniform cosine modulated filter bank（CMFB） based on the audiogram for digital hearing aids is proposed. First, a low-pass prototype filter is designed by the linear iterative algorithm. Secondly,the uniform CMFB is achieved on the basis of the principle formulas. Then, the adjacent channels of a uniform filter bank which have low or gradual slopes are merged according to the trend of audiogram of the hearing impaired person. Finally,the corresponding non-uniform CMFB is obtained. Simulation results show that the signal processed by the proposed filter bank is similar to the original signal in a time-domain waveform and spectrogram without significant distortion or difference. The speech quality results show that the personal evaluation of speech quality（PESQ） of non-uniform CMFB is 35% higher than that of the traditional design, and the hearing-aid speech quality index（HASQI） increases by about 40%.

摘要：本文对于一类含不确定输入时滞和干扰的非线性系统的跟踪控制问题提出了一种自适应动态面控制方案.利用动态面控制方法避免了传统的后推设计中存在的复杂度爆炸问题.分别构造了一个滤波器和一个虚拟观测器来产生辅助信号.采用神经网络来逼近未知的连续函数.跟踪误差被证明最终收敛到一个足够小的紧集.给出了一个数字仿真示例验证了理论结果.

摘要：A robust anti-swing control method based on the error transformation function is proposed,and the problem is handled for the unmanned helicopter slung-load system(HSLS)deviating from the equilibrium state due to the disturbances in the lifting ***,the nonlinear model of unmanned HSLS is ***,the errors of swing angles are constructed by using the two ideal swing angle values and the actual swing angle values for the unmanned HSLS under flat flight,and the error transformation functions are investigated to guarantee that the errors of swing angles satisfy the prescribed ***,the nonlinear disturbance observers are introduced to estimate the bounded disturbances,and the robust controllers of the unmanned HSLS,the velocity and the attitude subsystems are designed based on the prescribed performance method,the output of disturbance observer and the sliding mode backstepping strategy,***,the Lyapunov function is developed to prove the stability of the closed-loop ***,the simulation studies are shown to demonstrate the effectiveness of the control strategy.

摘要：With the significant discharge of antibiotic wastewater into the aquatic and terrestrial ecosystems, antibiotic pollution has become a serious problem and presents a hazardous risk to the environment. To address such issues, various investigations on the removal of antibiotics have been undertaken. Photocatalysis has received tremendous attention owing to its great potential in removing antibiotics from aqueous solutions via a green, economic, and effective process. However, such a technology employing traditional photocatalysts suffers from major drawbacks such as light absorption being restricted to the UV spectrum only and fast charge recombination. To overcome these issues, considerable effort has been directed towards the development of advanced visible light-driven photocatalysts. This mini review summarises recent research progress in the state-of-the-art design and fabrication of photocatalysts with visible-light response for photocatalytic degradation of antibiotic wastewater. Such design strategies involve the doping of metal and non-metal into ultraviolet light-driven photocatalysts, development of new semiconductor photocatalysts, construction of heterojunction photocatalysts, and fabrication of surface plasmon resonance-enhanced photocatalytic systems. Additionally, some perspectives on the challenges and future developments in the area of photocatalytic degradation of antibiotics are provided.