摘要：一项研究使用随机、双盲、双模拟交叉设计的方法．对18名健康志愿者进行试验，评估胰岛素的吸收率。每名受试者分别通过喷射注射或传统胰岛素笔注射的方式接受0．21U／kg体重的门冬胰岛素治疗，随后进行正葡萄糖钳夹试验评估。结果表明，相比传统笔式注射器，

摘要：背景 本研究的目的是评估来格司亭加地塞米松动员和收集嗜中性粒细胞的剂量响应关系。研究设计与方法本研究为前瞻性研究，260名健康志愿者接受了口服地塞米松（8mg）加中位数浓度1．5（1．0～2．3）μg／kg（n=43），3（2．4～4．1）μg／kg（n=73）。6（4．3～7．9）μg／kg（n=123）或12（8．2～17．2μg／kg（m=21）糖基化粒细胞集落刺激因子（G—CSF；来格司亭）一次皮下注射，并以多形核嗜中性白细胞（PMN）程序采集嗜中性粒细胞。比较白细胞计数和PMN动员和采集结果，

摘要：背景 在保持血小板（PLTs）品质的前提下，细菌学检测和病原体灭活可以延长血小板的保存期。研究设计和方法以Haemonetics单采机收集20名健康志愿者的PLTs。在保存期0天及8天后，测定PLT体外功能及代谢。到第8天，从每名献血者抽取少量血获得新鲜PLTs，用^51Cr或^111In标记新鲜的与保存的自体的PLTs，然后回输放射性标记的PLTs。

摘要：Objective: To evaluate rectal sensitivity in patients with pediatric constipat ion (PC) and nonretentive fecal soiling (FNRFS) using pressure-controlled diste ntion (barostat). Study design: Thresholds for rectal sensitivity (first sensati on, urge to defecate, and pain), and rectal compliance were determined using a b arostat. Results: A total of 69 patients with PC (50 males; mean age, 10.9±2.2 years) and 19 patients with FNRFS (15 males; mean age, 10.0±1.9 years) were com pared with 22 healthy volunteers (HVs) (11 males; mean age, 12.7±2.6 years). Se nsitivity thresholds were not significantly different among the 3 groups. Rectal compliance was increased in 58%of the patients with PC (P < .0001 vs HVs). Rectal compliance did not differ between patients with FNRFS and HVs. Children with PC with abnormal rectal function required significantly larger rectal volumes a t urge to defecate. Conclusions: Increased compliance is the most prominent feat ure in patients with PC. Because of higher compliance in these children, larger stool volumes are required to reach the intrarectal pressure of the urge to defe cate. Children with FNRFS have normal rectal function.