摘要：目的:通过高分辨率CT(HRCT)图像分析囊性纤维病(CF)患儿与正常儿童间是否存在气道结构差异。试验设计:获取肺完全膨胀及控制通气的状态的四维解剖水平的HRCT图像,研究对象包括34例CF患儿(年龄2.4±1.4岁)及20名正常对照儿童(年龄1.8±1.4 岁)。测量所有清晰可见的圆形通气管道的短轴直径以获取气道壁厚度(AWT),气道管腔内径(ALD)以及气道直径(VD)。结果:在CF组(x±s),AWT为0.58±0.13 mm,ALD为1.31±0.56 mm,VD为1.62±0.58 mm。在对照组:AWT为0.49±0.13 mm,ALD为1.07±0.42 mm,VD为1.86±0.64 mm。

摘要：Objective:To evaluate risk factors for recurrent thrombosis in pediatric patients. Study design:This prospective observational cohort study enrolled 120 patients with acute venous thromboembolism from January 2003 to April 2005. Datacollection included medical and family history,radiologic and laboratory studies,therapy,and follow-up. Results:The overall prevalence of recurrent thrombosis in our cohort was 19/120(15.8%). Patients with recurrence were older,with a median age of 14.8 years (range 2 weeks-23.6 years),compared with 10.1years (range newborn 23.4 years) in patients without recurrence(P = 0.03). Six of the 19 patients with recurrent thrombosis had cystic fibrosis (CF),compared with 0/101without recurrence (P< 0.001). Five of these 6 patients were colonized with Burkholderia cepacia in their sputum. Central venous catheters were associated with most,but not all,of the thromboses in patients with CF. Conclusions:In this study,patients with CF had a high risk of recurrent venous thrombosis,as well as a high prevalence of colonization with B cepacia. The cause of this risk has not been defined. This observation may have important implications for thromboprophylaxis,particularly in the setting of central venous catheters.