摘要：目的探讨视盘相关基因多态性与内蒙古自治区原发性开角型青光眼（POAG）易感性的关系。方法采用回顾性研究设计，纳入2014年1月至2016年12月内蒙古自治区（呼和浩特市、包头市）6所医院确诊的POAG患者108例作为POAG组，同期纳入120名健康体检者作为对照组。2个组患者用EDTA抗凝管抽取1—2ml全血，提取基因组DNA，充分混匀EDTA和全血，提取基因组DNA于-20℃冰箱中保存。采用质谱分析法对108例POAG患者和120例对照者的RFTN1（rs690037）、ATOH7（rs7916697、rs3858145）、CDC7（rs1192415）、CDKN2B（rs1063192）和SIX（rs10483727）单核苷酸多态性（SNP）位点进行基因分型，采用r检验和Logsitic二元回归分析各位点多态性与POAG发病的关系。结果POAG组CDKN2B（rs1063192）位点G等位基因频率高于对照组（27％与17％），差异有统计学意义[优势比（OR）=1．824，95％可信区间（CI）1．163～2．861，P=0．008]；2个组其他7个SNPs位点等位基因频率比较，差异均无统计学意义（均P〉0．05）。CDKN2B（rs1063192）位点的加性模型和显性模型显示，携带G等位基因个体罹患POAG风险增高，差异有统计学意义（P〈0．05），隐性模型显示，携带A等位基因个体罹患POAG风险无显著降低，差异无统计学意义（P〉0．05）。POAG和对照组其他SNPs各基因型分布比较，差异无统计学意义（P〉0．05）。结论CDKN2B（rs1063192）基因多态性与POAG易感性有关，G等位基因可增加个体罹患POAG的风险。

摘要：Objective: The Low- Pressure Glaucoma Treatment Study (LoGTS) seeks to evaluate visual field stability in low- pre- ssure glaucoma patients randomized to intraocular pressure reduction in both eyes with topical twice daily brimonidine tartrate 0.2% versus twice daily timolol maleate 0.5% . This article describes the LoGTS design and presents baseline characteristics of the subjects. Design: Randomized, multicenter, double- masked clinical trial. Participants: Low- pressure glaucoma patients 30 years of age or older were identified. Exclusion criteria included an untreated pressure of more than 21 mmHg, advanced visual field loss, and contraindications to study medications. Interventions: Randomization of both eyes to double- masked monotherapy with brimonidine or timolol. Follow- up visits included Humphrey 24- 2 full- threshold perimetry, tonometry every 4 months, and annual optic disc photography. Main Outcome Measure: Progression of visual field loss. Results: One hundred ninety patients were randomized between 1998 and 2000. Mean age (± standard deviation) was 64.9± 10.7 years. Women comprised 59.5% of the patients. Fifty- three patients (27.9% ) had unilateral field loss. The 137 patients with bilateral field loss were older than those with unilateral field loss: 65.7 versus 62.3 years of age (P< 0.05). Mean untreated diurnal intraocular pressures were similar between the eyes of the bilateral patients (mean, 15.5 mmHg in both eyes) and unilateral patients (mean, 16.0 mmHg in field loss vs. 15.6 mmHg in fellow eyes). Visual field mean deviation for all eyes was- 5.4± 4.7 decibels. Central corneal thickness in 168 phakic patients was 543± 35 μ m (range,435- 655 μ m); thickness was less than 500 μ m in 15 eyes and was more than 600 μ m in 11 eyes. Mean vertical cup- to- disc ratio for all eyes was 0.67± 0.15. Unilateral field loss patients had a larger cupto- disc ratio in the field loss eye (0.75± 0.12) than the fello weye with a normal field (0.60± 0.17, P< 0.0