摘要：The eukaryotic genome is packaged into a complex nucleoprotein structure named chromatin, balancing the compactness of genome and the accessibility of regulatory proteins and RNA polymerases to DNA. The mechanisms of the regulation of chromatin dynamics include the post-translational modification of histones, alteration of nucleosome positions by chromatin remodelers, replacement of canonical histones by histone variants with the aid of histone chaperones, and dynamic organization of the three-dimensional genome in the small nucleus. Histone variants are different from canonical histones by substitution of several amino acid residues or changes in amino acid sequence. Histone variants perform specialized functions such as altering nucleosome stability, dynamics, structure, as well as playing critical roles in a range of biological processes like transcriptional regulation, DNA repair and recombination, development and immune responses. Here we discuss how histone variants, their modification and specific loading to chromatin are involved in transcriptional regulation, DNA repair and plant development.

摘要：基因与衰老研究的进展山西省人民医院（０３００１２）张申鸿关于衰老的研究，从本世纪３０年代以来，根据衰老的各种表现，提出内分泌失调、免疫系统衰退、自由基积累的损害、蛋白质变性、微量元素谱异常等学说，设计各种试验，说明与衰老的关系，但随着分子生物学的进步...

摘要：在细胞有丝分裂的仿真过程中，染色体与中心体的形态和运动具有非常明显的特征，该文建立了一个基于非线性函数的染色体与中心体的仿真模型，并采用ＶｉｓｕａｌＣ＋＋进行面向对象的程序设计，结果表明该模型能较好地模拟其动态特性。