摘要：产油海洋真菌DXD-1在培养过程中出现细胞凝集现象,给菌体生长和产物合成造成一定的影响,探讨菌体凝集原因并设计出相应的解决办法,有利于了解菌体特性并提高产油能力。

摘要：目的:测定大蒜提取液与环丙沙星联合对铜绿假单胞菌PAO1、PAO-JP2生物被膜的影响进行研究,探讨联合用药对生物被膜细菌杀菌活性的作用。方法:采用棋盘法设计,分为空白对照组、大蒜提取液组、环丙沙星组、大蒜和环丙沙星组。结果:1/16、1/4MIC的大蒜提取液单独作用并不能使BF活菌数减少,但是1/16、1/4MIC的大蒜提取液却可以增强1/4MIC、1/2MIC、1MIC的环丙沙星对BF细菌的抑制作用。结论:大蒜提取液与环丙沙星联用对PAO1、PAO-JP2生物被膜抗菌有增效作用。

摘要：Abstract Abstract Background: Despite several attempts to make the conventional tubular stents with a central lumen for flow less susceptible to a biofilm buildup and thereby prevent clogging, this goal has remained elusive. We hypothesized that the creation of pathways for fluid flow around the stent instead of through it would avoid this problem. The aim of our study was to report the development and the evaluation of a novel lumen-less stent. Methods: By using a software computer modeling, a 10F “ winged" stent was designed. A pilot feasibility study was performed by using a prototype of this stent for endoscopic biliary drainage in 5 patients with malignant biliary obstruction. Observations: Modeling data revealed that the winged stent offers a larger surface area for flow, higher velocity of flow, and increased flow rates compared with the conventional tubular stent. In the clinical trial, there was a significant decrease of serum bilirubin after the placement of this stent (serum bilirubin before and 2 weeks after stent placement, 14.94 ± 5.7 mg/dL vs. 2.86 ± 1.4 p < 0.004 ), accompanied by radiologic evidence of decompression of the biliary system. Conclusions: We have shown that it is possible to provide adequate biliary drainage by using a stent without a lumen. Such a design may have potential clinical advantages over existing designs.