摘要：目的:研究补肾活血颗粒对帕金森病(Parkinson's Disease,PD)患者睡眠量表(Parkinson's disease sleepscale,PDSS)评分的影响。方法:将120例PD患者网上在线随机分成治疗组60例和安慰剂对照组60例。其中治疗组服用补肾活血中药,对照组服用安慰剂,2次/d,两组均以美多芭等西药为基础治疗。两组患者均以3个月为治疗观察期,采用双盲设计,疗程结束后带药随访6个月观察。采用PDSS量表评定患者治疗过程中睡眠状况的变化。结果:对照组患者睡眠质量在治疗9个月中均未有改善(P>0.05)。治疗组患者无论在治疗观察期还是随访观察期中,PDSS的评分均显著下降(P<0.01)。研究过程中未发现明显不良反应。结论:补肾活血中药可以改善PD患者睡眠质量,且疗效稳定、不易反弹。

摘要：近年微信小程序以便捷特性得到许多用户的喜爱,目前市面上虽然已有许多睡眠相关软件,但睡眠助手类小程序还很少或不成熟。从用户需求出发,设计并开发了一款基于微信小程序的“睡眠助手”软件,提供睡眠科普知识、睡眠量表打分、助眠音乐、自动问答等功能。软件有助于科学了解睡眠、辅助改善睡眠,具有较好应用价值。

摘要：The purpose of this study was to test whether modafinil is effective in alleviating the symptoms of fatigue in postpolio patients, because it has been helpful for such symptoms in other neurologic disorders. Using a double-blind, randomized, placebo-controlled cross-over design, 14 postpolio patients with moderate to severe fatigue were assigned to receive modafinil or placebo first. Piper Fatigue Scale, Epworth Sleepiness Scale, digit span, and reaction time tests were done at baseline and then at weekly intervals. The Piper Fatigue Scale scores im proved by 27 ±40%(mean ±SD) following modafinil and by 43 ±36%following pla cebo. Scores for most of the other tests did not change during the study. Therefore, we conclude that modafinil was not effective in alleviating the symptoms of fatigue in postpolio patients.