摘要：Objective: To determine the safety and effectiveness of managing intrauterine death after 24 weeks gestation using a combination of mifepristone and misoprost ol. Study design: Two regimens are compared. Twenty-nine women (group one)-wer e managed using a combination of oral mifepristone and vaginal/oral misoprostol. After a change in dosage and route of administration, a further 20 women were m anaged with oral mifepristone and vaginal misoprostol (group two). Results: All women delivered vaginally. The mean induction to delivery interval in group one was 7 h compared with 10.2 h in group two. Group two experienced fewer gastroint estinal side-effects than group one. Conclusion: This study confirms that the c ombined use of mifepristone and misoprostol is a safe and effective way of manag ing IUD after 24 weeks gestation. Regimen one results in a shorter induction to delivery interval but is associated with a higher incidence of gastrointestinal side-effects.

摘要：Objective: The purpose of this study was to assess the association between previous maternal Toxoplasma gondii (T gondii) infection and risk of fetal death. Study design: This was a population-based prospective cohort of 29,912 pregnant women without acute T gondii infection in Norway. Results: In the study population, 2937 (9.8% ) women had evidence of previous maternal T gondii infection, and 299 (1.0% ) had fetal deaths. We found no association between previous T gondii infection and risk of fetal death at ≥ 20 weeks of gestation. We did find a trend for an increased risk of fetal death at ≥ 16 and < 20 weeks of gestation. However, we noted no association between previous T gondii infection and risk of fetal death at all birth weight categories (≥ 1000, ≥ 500 and <1000, and < 500 g). Conclusion: These data do not indicate an increased risk of fetal death at ≥ 20 weeks of gestation in women with previous maternal T gondii infection.

摘要：目的研究孕妇打鼾、睡眠姿势以及其他睡眠习惯与晚期胎死宫内风险是否相关。设计以人群为基础的前瞻性病例对照研究。

摘要：Background: The purpose of this study was to assess the efficacy, side effects and cost of misoprostol regimens in various obstetrical situations frequently occurring in deve-loping countries. Study design: One hundred and four parturient women with indications for labor induction received different regimens of misoprostol in the range of 50-800 μg according to their gestational age. Misoprostol was administered by the vaginal route, every 6 h without exceeding four doses. Results: All indications for labor induction concerned women with a gestational age of more than 30 weeks, except in the intrauterine death cases. The mean overall duration of labor was 7.8 h (±4.6 h). The mean amount of misoprostol used was 226 μg (±196 μg). The difference in the mean labor duration between the four indications for induction was statistically significant (P < 0.01). It was also significant for the mean total dose of misoprostol used. Total dose of misoprostol and Bishop score were inversely proportional. Two caesarean deliveries and two uterine ruptures were recorded, but no maternal deaths. The mean Apgar score was 8.0 (±1) at 1 min and 9.5 (±0.8) at 5 min. In our series, four fetal deaths occurred. The mean cost of misoprostol for labor induction was around US＄1, with a range of ＄0.05-4. Conclusions: The use of vaginal misoprostol appears to be relevant in developing countries in cases where labor induction is indicated. Nevertheless, the advantages of misoprostol (low cost, facility of storage) are counter-balanced by side-effects (C-section, uterine rupture) which can be harmful for the mother and also for the newborn.