摘要：目的:为了评估儿童尿酶联免疫吸附试验(ELISA) 抗幽门螺杆菌免疫球蛋白G抗体试剂盒(尿- HpELISA)的准确性,笔者将其同13C尿素呼吸试验(UBT)和幽门螺杆菌粪便抗原试验(HpSA)做一对比, 以分析其敏感性和特异性。研究设计:选择没有明显上腹部症状的100例日本儿童分别用UBT、HpSA及尿- HpELISA法进行测试(平均年龄7岁,介于2-15岁之间)。结果:通过UBT和HpSA试验,100例儿童中,36例幽门螺杆菌阳性,64例阴性。36例阳性试验者中尿- HpELISA法测试出34例为阳性,而64例阴性者中用尿-HpELISA法测试出62例为阴性,因此,尿-HpELISA 法有94.4%的敏感度及96.9%的特异性,准确率达到了96.0%。结论:尿-HpELISA法是诊断儿童幽门螺杆菌感染的迅速、廉价、可靠并易于操作的一种方法。它不仅对诊断儿童幽门螺杆菌感染有价值,而且对儿童群体大规模流行病学筛查也有价值。

摘要：Objective: To describe the clinical and laboratory manifestations of childhood -onset systemic lupus erythematosus (SLE) at presentation. Study design: This r etrospective French multicenter study involved 155 patients in whom SLE develope d before the age of 16 years. Mean patient age at onset was 11.5 ±2.5 years (ra nge, 1.5-16 years). The female to male ratio was 4.5. Results: The most common initial manifestations were hematologic (72%), cutaneous (70%), musculoskeleta l (64%), renal (50%), and fever (58%). Thirty-two percent of children had at ypical symptoms, mainly including abdominal involvement in 26 patients, which le ad to negative laparotomy results for presumed appendicitis. Severe renal, neuro logic, hematologic, abdominal, cardiac, pulmonary, thrombotic, and/or cutaneous manifestations occurred within the first month after the diagnosis in 40%of pat ients. The mean erythrocyte sedimentation rate was 72 ±29 mm/h, and the mean C -reactive protein value 22 ±21 mg/L. Antinuclear antibodies an, anti-double s tranded DNA antibodies, and low C3 or C4 level were retrieved in 97%, 93%, and 78 %of patients, respectively. Conclusion: Initial manifestations of childhood -onset SLE are diverse and often severe. The diagnosis of SLE should be promptl y considered in any febrile adolescent with unexplained organ involvement, espec ially when associated with an increased erythrocyte sedimentation rate.