摘要：In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-aids drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of IH NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-aids drug has been synthesized.

摘要：The visual navigation marks are established purposely,which transfer information to the trained observer in order to *** visual aids to navigation in freshwater could give aid to *** addition,through its basic shape,appearance forms and colors,the landscape of navigation waterway is also *** aids to navigation together with channel revetment and other surrounding landscape elements determine the landscape effect of the navigation *** analyzing the design of aids to navigation features,the design impact factors,the landscape design principles and methods of treatment are proposed in this research,in order to provide some references for the design of future visual aids to navigation.

摘要：Background: Designing a need-based social protection intervention for children comes as comprehensive tool for addressing the overall quality of life of HIV positive children. Not much has been examined on what constitute the desired social protection framework for HIV positive children. Methods: This study was informed by a qualitative descriptive exploratory design approach. The study drew insights from the shared perspectives of 27 participants sampled from positive HIV status disclosed children—10 - 17 years, healthcare workers, Social and Development worker, HIV positive caregivers and parents from 7 ART clinics in rural and urban Brong Ahafo and Ashanti regions of Ghana. Data was collected through interviews and two focus group discussions with study participants. Drawing on the emerged themes from the transcripts, thematic content analysis was used to analyze the data using comparative thematic framework approach. Findings: The eclectic perspectives on the type of social protection policy/intervention preferred demonstrated the need for an interrelated and integrated social protection policy. This should not be designed in isolation towards addressing the child vulnerability. The study found that social protection policies aimed at addressing vulnerability levels of children should consider the dual vulnerability situation within which HIV positive children and adolescents are located. A set of unique specific tailored approach and package reflecting minimum combination social protection package to HIV positive children was considered essential for inclusion. The themes that emerged covered social policy/intervention package inclusive of a disease ending/eradication intervention package, cash transfer for children and their caregivers, free comprehensive health insurance integrating all consultancy and laboratory services charges, direct food supplements supply and nutritional support, research, target specified with evidenced-based monitoring. Counseling sup

摘要：艾滋病(aids)是由人免疫缺陷病毒(HIV)感染引起的一种传染病。HIV感染的进展主要表现为病毒感染的CD4+T细胞迅速破坏和高致病性HIV毒株的出现[1]。病毒感染与宿主的免疫应答、免疫激活之间复杂、动态的相互作用,在本病的发病机制中具有重要意义[2]。由于HIV感染的临床过程是多变的,因此,艾滋病的临床诊断及预测病情的进展,可依据病毒载量、CD4+T细胞计数及免疫激活标志物(β2微球蛋白,β2M)水平的变化综合评估[3]。为了更深入地了解β2M在HIV感染患者中的临床意义,设计前瞻性临床对照试验,对我院56例HIV感染者及20例健康人进行了统计学分析。1对象与方法1.1研究对象观察组为2

摘要：为了解高校新生艾滋病防控知识的现况,评价健康教育讲座的干预效果,本研究通过随机整群取样方法,以江西省五所地区医学一年级学生为研究对象,由专家进行专题讲座开展相关教育。研究对象在干预前后分别填写事先统一设计的相同问卷,统计分析有关数据,评价干预效果。结果显示,教育干预后,研究对象对aids基本知识与传播途径、个人防病态度与行为意向的正确认知均有所提高,表明在高校新生中开展艾滋病知识的健康教育十分必要。

摘要：人类获得性免疫缺陷综合征(AcquiredLmmunodeficienlySyndrome,aids,艾滋病)的病原体是人类免疫缺陷病毒(humanimmunodeficienlyvirus,HIV),它感染率高传播速度快。近二十年来,抗aids的治疗虽然有了显著进展,自1987年美国食品和药品管理局批准了第一个治疗aids的药物-叠氮胸苷至今已经批准了多种化学药物用于抗逆转录病毒的治疗,它们可抑制逆转录酶、蛋白酶或整合酶的活性,但都存在在抗病毒作用的持久性,以及长期使用后出现的耐药问题。目前针对aids治疗的手段很多,主要包括抗HIV治疗和设计靶向药物治疗两方面。大多数尚处于临床实验阶段。

摘要：目的探讨aids机会性感染的心理健康水平和影响因素。方法参考相关资料设计的一般情况调查表症状自评表(SCL-90)对97例aids机会性感染患者进行测试研究。结果 aids机会性感染患者的SCL-90总分明显高于健康人群。除人际关系敏感外,其余因子躯体化、强迫、抑郁、焦虑、敌对、恐怖、精神病性及其他因子的得分均比健康组高(P<0.01)。结论 aids机会性感染患者心理健康状况差,应努力提高护理人员心理和社会学知识,实施个体化心理疏导。呼吁政府制定长期的支持计划。

摘要：结合生物学特有的学科属性,设计、开展生物学科与社会性民生问题有机结合的教学活动,在形成、认同诸多生命观念的同时,发展学生的科学思维能力和社会责任感,符合新课标学生核心素养的发展要求。

摘要：目的了解感染科医务人员对aids患者口腔护理知识的认知状况,分析其影响因素,确定对策。方法采用自行设计调查问卷的方法,对昆明市第三人民医院感染科30名医务人员发放问卷,对28份有效问卷进行统计分析。结果有25%的医务人员完全掌握口腔护理的相关知识及正确的口腔护理的方法,75%的医务人员仅部分掌握,感染科医务人员对于aids患者的口腔护理知识的认知有待加强;对于口腔护理知识,不同学历、职称、工作年限的医务人员之间知识得分差异无显著性(P>0.05);对于不同口腔损害表征的患者未进行分类管理;有82.1%的医务人员的口腔护理知识获知途径仅来源于教科书,表明医务人员的知识教育途径单一。结论应对感染科医务人员加强相关培训,以提高其对aids患者口腔护理相关知识认知水平。

摘要：目的探讨提高基层医院护士HIV/aids职业防护水平的培训方式。方法设计微课程教学并搭建微信交流平台,对295名基层医院护士进行HIV/aids知识与防护行为培训,培训6周后,对同一目标人群追踪调查,并评价干预效果。结果培训后护士HIV/aids相关知识与职业防护行为评分显著高于培训前(均P<0.01)。结论微视频结合微信平台用于基层医院护士HIV/aids知识培训,可提高其HIV/aids相关知识和防护行为依从性。