摘要：Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous ***,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body ***,inflammation of the wound area can dramatically worsen in response to bacterial *** consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of ***,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto *** encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive ***,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat *** to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain *** approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

摘要：Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950 *** to the excellent mechanical tribological properties,corrosion resistance,biocompatibility,and antibacterial properties of titanium,it is getting much attention as a biomaterial for ***,titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant *** properties are crucial for producing high-strength metallic alloys for biomedical *** alloys are manufactured into the three types ofα,β,andα+β.The scientific and clinical understanding of titanium and its potential applications,especially in the biomedical field,are still in the early *** review aims to establish a credible platform for the current and future roles of titanium in *** first explore the developmental history of ***,we review the recent advancement of the utility of titanium in diverse biomedical areas,its functional properties,mechanisms of biocompatibility,host tissue responses,and various relevant antimicrobial *** research will be directed toward advanced manufacturing technologies,such as powder-based additive manufacturing,electron beam melting and laser melting deposition,as well as analyzing the effects of alloying elements on the biocompatibility,corrosion resistance,and mechanical properties of ***,the role of titania nanotubes in regenerative medicine and nanomedicine applications,such as localized drug delivery system,immunomodulatory agents,antibacterial agents,and hemocompatibility,is investigated,and the paper concludes with the future outlook of titanium alloys as biomaterials.

摘要：纳米材料因其特殊的抗菌机理,在抗菌领域得到了广泛应用.氧化铈纳米粒子是重要的抗菌材料之一,具有对正常细胞毒性低,且抗菌机理基于可逆价态转化的优势.目前已有许多关于氧化铈纳米粒子抗菌活性的研究报道,但系统性探究其抗菌机理的文章则极为少见.本文首先系统性地探究了氧化铈纳米粒子可能的抗菌机理,即静电相互作用在抗菌过程中发挥重要作用,此外抗菌过程还伴随活性氧物种的产生和纳米粒子对细菌的机械损伤.其次,本文分析了氧化铈纳米粒子抗菌效果的影响因素,并总结了不同研究中氧化铈纳米粒子对大肠杆菌和金黄葡萄球菌的抗菌效果.最后提出了氧化铈纳米粒子可能的应用前景.本文将有利于对氧化铈纳米粒子抗菌机理的深入理解,并为该类材料在未来的设计和应用提供借鉴.

摘要：过滤介质作为过滤装置中的关键材料可改变流经其中的水的质量.正确选择过滤介质对于过滤装置的过滤性能至关重要.再生玻璃作为介质过滤装置中硅砂的替代品,具有比硅砂廉价、环境友好、可再生等优点,并且可以根据特定的设计要求将其粉碎成不同的尺寸.然而,水中存在大量的诸如细菌和藻类的微生物,故再生的可循环玻璃介质的过滤效率受到在其表面富集的生物膜的极大限制.本研究中,我们通过在钠钙玻璃球(GS)表面上进行氢氟酸(HF)蚀刻和原位结晶制备了用聚多巴胺(PDA)和银(Ag)纳米颗粒改性的氢氟酸蚀刻玻璃球(PDA-Ag-HF/GSs).银晶体的原位生长、HF蚀刻和PDA涂层的改性赋予了PDA-Ag-HF/GS良好的亲水性.银涂层的改性还使得PDA-Ag-HF/GS具有出色的抗菌性能和较小的球藻附着力,且通过释放Ag离子可抑制微生物的生长.PDA涂层上的邻苯二酚官能团可通过螯合作用调节Ag离子的释放.良好的抗菌性能、抗藻类附着力和Ag离子的受控释放表明,PDA-AgHF/GS涂层可有效抑制材料表面生物膜的形成,为抗生物膜的形成提供了新的策略.