摘要：biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the *** has undergone a remarkable transformation in the last two decades,entering the era of BM4.0 and becoming a pivotal driver of the sustainable ***,Japan has made significant advances in BM,contributing to its development through the creation of innovative materials,advanced processes,and interdisciplinary ***,because of certain development policies,this research has not been widely recognized on an international *** paper provides a comprehensive summary of the research progress made by renowned Japanese laboratories and researchers in biomedical materials,bio-three-dimensional(3d)printing,and biomedical applications in the last five *** unique contributions are introduced and analyzed,illuminating the distinctive approaches and breakthroughs within each ***,this review highlights the current challenges and prospects of *** viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in Japan.