摘要：介绍计算机辅助设计与绘衅技术在江南造船厂承接的高层钢结构大楼－世界金融大厦结构细部设计图中的应用情况。这一技术的有效实施，在高层钢结构建筑设计绘图中探索了一条高效，确定可行的路子。

摘要：论述了开发感应电炉cadd系统的重要性,cadd系统的最佳工作环境,在产品设计中所起的作用及该系统将来的潜力和发展方向。

摘要：计算机辅助药物设计的理论和方法Computer-aided drug design(cadd),己经从原来的基础理论研究发展成为一门综合实用的学科,成为国际上十分活跃的研究领域,且随着cadd技术应用的深入,cadd技术已应用于中药及其复方的研究。本文就cadd技术在中药及复方药效物质基础研究中的应用进行探讨。

摘要：A new series of sulfonamide flavone derivatives are designed as non-covalent inhibitors of proteasome assisted with computer-aided drug design （cadd）. The desired compounds were synthesized successfully and the biological evaluation was subsequently accomplished. The results showed negligible improvement from our lead compound （IC50 for β5 subunit was 14.0 μM）. Thus, these flavone derivatives might be improved as potential 20S proteasome inhibitors.

摘要：Computer aided fragment-based lead discovery has been successfully applied to the design of inhibitors of aspartyl protease enzyme β-secretase（BACE1）.A benzimidamide fragment,which binds to the two catalytic aspartic acid residues in the active site of the enzyme,was selected as the starting compound.A novel series of 3-phenethylbenzimidamide inhibitors were designed and *** biological evaluation results showed that the compounds displayed poor inhibitory activity towards BACE1,3-phenethylbenzimidamide analogs might be modified as potential BACE1 inhibitors.

摘要：Strategies for cadd vary depending on the extent of structural and other information available regarding the target (enzyme/receptor) and the ligands. Computer-aided drug design (cadd) is an exciting and diverse discipline where various aspects of applied and basic research merge and stimulate each other. In the early stage of a drug discovery process, researchers may be faced with little or no structure activity relationship (SAR) information. The process by which a new drug is brought to market stage is referred to by a number of names most commonly as the development chain or “pipeline” and consists of a number of distinct stages. To design a rational drug, we must firstly find out which proteins can be the drug targets in pathogenesis. In present review we reported a brief history of cadd, DNA as target, receptor theory, structure optimization, structure-based drug design, virtual high-throughput screening (vHTS), graph machines.

摘要：本文介绍计算机辅助分子模拟法(CAMM)在药物设计中的应用,基本配置,软件包***-X和Biograph的主要功能,以及计算机辅助药物设计(cadd)的一般途径和国内应用现状。

摘要：电脑的出现,使世人感到了科技革命的重大飞越.随着电脑技术的不断发展,适合于各行各业的应用软件被相继开发出来,而且在很短的时间内推陈出新,其中最引人注目的是电脑二维平面以及三维空间设计制作软件.

摘要：目的:介绍从头药物设计技术。方法:举例说明从头药物设计技术的应用。结果:从头药物设计已应用于新药研发。结论:该技术应用前景广阔。

摘要：本文介绍了一种用于注塑模具设计的微型计算机辅助设计与绘图（ＣＡＤＤ）软件包。利用此软件包可实现全套模具装配图及零件工作图的半自动生成。软件实用可靠，操作方便，是注塑模设计师的好帮手，是中小型企业开展模具ＣＡＤ有效工具。