摘要：Natural polyphenols are a large class of phytochemicals with neuroprotective effects. Four polyphenolic compounds: hesperidin, icariin, dihydromyricetin and baicalin were selected to evaluate their effects on Alzheimer's disease(AD). We analyzed by an inverse docking procedure(INVDOCK) the potential protein targets of these polyphenols within the KEGG AD pathway. Consequently, their therapeutic effects were evaluated and compared in a transgenic APP/PS1 mouse model of AD. These polyphenols were docked to several targets, including APP, BACE,PSEN, IDE, CASP, calpain and TNF-a, suggesting potential in vivo activities. Five month old transgenic mice were treated with these polyphenols. Icariin and hesperidin restored behavioral deficits and ameliorated Aβ deposits in both the cortex and hippocampus while baicalin and dihydromyricetin showed no substantial effects. Our findings suggest that hesperidin and icariin could be considered potential therapeutic candidates of human AD.

摘要：This paper presents an adaptive Under Frequency Load Shedding scheme based on Wide Area Measurement System. Due to the lack of enough adaptability to the operation state of the system, the traditional successive approximation under frequency load shedding method will cause excessive cut or undercut problems inevitably. This method consists first in a comprehensive weight index including load characteristics and inertias of generators. Then active-power deficit calculation based on the Low-order Frequency Response Model, concerning the effect of voltage was put forward. Finally, a dynamic correction of the load shedding amount was proposed to modify the scheme. This approach was applied to IEEE-39 system and the simulation results indicated that the proposed method was effective in reducing the load shedding amount as well as the frequency recovery time.