摘要：Recently,organ-on-chips have become a fast-growing research field with the widespread development of microfluidic chips and synthetic materials in tissue *** to the existing cardiotoxicity of many cardiovascular drugs,heart-onchips which are promising to replace traditional animal models have been extensively researched and developed to mimic human organ functions in *** heart-on-chips mainly focus on cardiac mechanics,which is regarded as the central indicator of in vitro heart models and drug *** methods for the detection of myocardial mechanics have been demonstrated complex and inefficient in ***,photonic crystal materials with unique optical properties have attracted interests and have been introduced into the heart-on-chips,developing a visualized self-reporting system for cardiomyocytes activity *** this review,photonic crystal-based heart-on-chips for biosensing are introduced,as well as the fabricationmethods and design criteria of *** characterizations of the photonic crystal materials are classified into optical properties and structural properties,and their applications in cell culture and biosensing are further ***,several representative examples and developments of the integration of photonic crystal materials into microfluidic chips are described in ***,potentials and limitations are put forward to promote the development of the photonic crystal-based intelligent heart-on-chips.