摘要：Prosthesis implantation and fat transplantation are common breast *** general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct *** date,no reports have focused on methods of combining fat with implanted prostheses for breast *** a newly designed bionic ink(i.e.,polyether f127 diacrylate(f127da)&poly(ethylene glycol)diacrylate(PEGda))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous *** was used to improve the printing precision of the prosthesis by increasing the gel point of f127da and reducing the impact of external *** compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural ***,stromal vascular fraction gel(SVf-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose *** were implanted subcutaneously in nude mice to observe their biological *** 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the *** result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.