摘要：Owing to the tremendous advantages and unique well-defined nanoscale structure,polyhedral oligomeric silsesquioxanes(poss)have received considerable interest in the design of novel organic-inorganic hybrid nanomaterials with all manner of prominent capabilities,which is rec-ognized as a new generation of promising materials for advanced applications of material sci-ence,engineering science and biomedical *** from the recent progress in combi-nation of controlled/living polymerization and emerging click chemistry,poss-based hybrid ma-terials with ingenious design,versatile topological structure and sophisticated multifunctionality have been successfully fabricated and developed into abundant well-defined hybrid nanostruc-tures with desired physicochemical ***-made amphiphilic molecular design and nanosized hybrid architecture provide opportunities for the self-assembly of poss-based hybrid materials with unique hierarchical morphologies in selective *** the in-depth understanding of structure-properties relationship,poss-based hybrid materials can achieve the modulation of precise control of self-assembling process and multi-purpose applications with improved material *** this review,we summarize the recent advances of poss-based hybrid materials in molecular design,self-assembly behavior in solutions and poten-tial biomedical applications with main concerns on drug delivery,gene therapy,bioimaging and tissue engineering ***,future directions and remaining challenges for further advance-ment of poss-based hybrid materials are proposed and discussed.