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Design,synthesis and biological estimation of 1-(benzoxazole-2-yl)piperazine and 4-(benzoxazole-2-yl)piperidine derivatives as potentialα_1-AR antagonists: 收藏
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引用; 《Chinese Chemical Letters》2008年第10期19卷 1193-1195页; 作者：Jia Bin Li Lin Xia Bin Wu Tao Wang Zhen Zhou JiangDepartment of Inorganic Chemistry China Pharmaceutical University Nanjing 210009 China Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China National Drug Screening Center China Pharmaceutical University Nanjing 210009 China School of Pharmacy Nanjing Medical University Nanjing 210029 China; Two series of 1-（benzoxazole-2-yl）piperazine （Sa-i） and 4-（benzoxazole-2-yl）piperidine compounds （10a-i） were designed, synthesized and evaluated for their α1-AR antagonistic activities. Biological assay in v...; Two series of 1-（benzoxazole-2-yl）piperazine （Sa-i） and 4-（benzoxazole-2-yl）piperidine compounds （10a-i） were designed, synthesized and evaluated for their α1-AR antagonistic activities. Biological assay in vitro indicated that 10h showed slightly stronger α1-AR antagonistic activity to that of our lead compound 1.; 来源：详细信息评论

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