摘要：In this paper, a neural network approach was employed to deal with blending problem with surface construction based on digitized points, and some related computational cases were presented. Compared with the NURBS method, this neural network based approach doesn't need the complex formula derivation as long as a limited number of offset points are got, and its accuracy can meet the general engineering needs.

摘要：The surface topography of acetabular implants plays a key role in providing cell attachment and *** measurement and characterisation of the surface texture of the cellular scaffold layer on the acetabular cup are very difficult due to the 3D nature of scaffold *** is proposed to use X-ray computed tomography(XCT)to measure the surface texture of an electron beam melting-produced titanium acetabular *** surface texture of its cellular scaffold is evaluated using the newly developed 3D surface texture parameters,which allows surface characterisation on 3D triangular mesh *** commonly used height parameters,*** arithmetical mean height Sa,the root mean square height Sq,the skewness Ssk and the kurtosis Sku,are calculated from surface patches extracted from the XCT scanned triangular mesh *** addition,the surface peak density and pit density,which are more related to cell communication and proliferation,are estimated based on the 3D watershed *** Wolf pruning with an empirical threshold 12μm is used to control the over-segmentation.

摘要：surface and interfacial behavior of protein molecules are crucial for the protein function involved in many biochemical processes and biomedical products such as enzyme design,bio-separation,drug design and *** article is devoted to an overview of design and regulation of the surface and interfacial behavior of protein *** improvement of enzyme surface such as the directed evolution and the rational design of enzymes is introduced at first,followed by the rational design of protein interface for the protein ***,the design of micro-environment and ligands are described as two examples for the design guided by protein *** the design of protein surface and interface with the help of artificial intelligence will be discussed.

摘要：Minimizing the impact of the mixed uncertainties(i.e.,the aleatory uncertainty and the epistemic uncertainty) for a complex product of compliant mechanism(CPCM) quality improvement signifies a fascinating research topic to enhance the ***, most of the existing works in the CPCM robust design optimization neglect the mixed uncertainties, which might result in an unstable design or even an infeasible design. To solve this issue, a response surface methodology-based hybrid robust design optimization(RSM-based HRDO) approach is proposed to improve the robustness of the quality characteristic for the CPCM via considering the mixed uncertainties in the robust design optimization. A bridge-type amplification mechanism is used to manifest the effectiveness of the proposed approach. The comparison results prove that the proposed approach can not only keep its superiority in the robustness, but also provide a robust scheme for optimizing the design parameters.

摘要：Lightweight design is important for the Thermal Protection System(TPS) of hypersonic vehicles in that it protects the inner structure from severe heating environment. However, due to the existence of uncertainties in material properties and geometry, it is imperative to incorporate uncertainty analysis into the design optimization to obtain reliable results. In this paper, a six sigma robust design optimization based on Successive Response surface Method(SRSM) is established for the TPS to improve the reliability and robustness with considering the uncertainties. The uncertain parameters related to material properties and thicknesses of insulation layers are considered and characterized by random variables following normal distributions. By employing SRSM, the values of objective function and constraints are approximated by the response surfaces to reduce computational cost. The optimization is an iterative process with response surfaces updating to find the true optimal solution. The optimization of the nose cone of hypersonic vehicle cabin is provided as an example to illustrate the feasibility and effectiveness of the proposed method.

摘要：The interface between metal nanoparticles(NPs)and support plays a vital role in catalysis because both electron and atom exchanges occur across the metal-support ***,the rational design of interfacial structure facilitating the charge transfer between the neighboring parts remains a ***,a guided nucleation strategy based on redox reaction between noble metal precursor and supportsurface is introduced to construct epitaxial interfaces between Pt NPs and CeO2 *** Pt/CeO2 catalyst exhibits near room temperature catalytic activity for CO oxidation that is benefited from the well-defined interface structure facilitating charge transfer from CeO2 support to Pt ***,this general approach based on support-surface-induced-nucleation was successfully extended to synthesize Pd and Cu nanocatalysts on CeO2,demonstrating its universal and feasible *** work is an important step towards developing highly active supported metal catalysts by engineering their interfaces.

摘要：Laminar flow design is one of the most effective ways to reduce the drag of a commercial aircraft by expanding the laminar flow region on the surface of the aircraft. As material science develops, the emergence of new materials such as low surface energy materials has offered new choices for laminar flow design of commercial aircraft. Different types of low surface energy micro-nano coatings are prepared to verify the effects on the boundary layer transition position and the drag of the airfoil through wind tunnel tests. The infrared thermal imaging technology is adopted for measuring the boundary layer transition, while the momentum integral approach is employed to measure the drag coefficient through a wake rake. Infrared thermal imaging results indicate that the coatings are capable of moving backward the boundary layer transition position at both a low velocity of Mach number 0.15 and a high velocity of Mach number 0.785. Results of the momentum integral approach demonstrate that the drag coefficients are reduced obviously within the cruising angle of attack range from 1° and 5° by introducing the low surface energy micro-nano coating technology.

摘要：Microfluidic device with patterned microstructures on the substrate surface was used to regulate cell adhesion,morphology,and functions in tissue *** developed a microfluidic device which employing microscale patterned microstructures to achieve enhanced cell adhesion and *** hydrogel substrates with micro-wavy and lattice-patterned microstructures were fabricated using standing surface acoustic waves and ultraviolet *** seeding the L929 mouse fibroblast cells onto the patterned substrate of the microfluidic device,we determined that the viability and proliferation rate of cell migration can be greatly ***,L929 cells showed two types of gathering modes after 48 h of *** growth was guided by the patterned substrate used in the microfluidic device and showed differences in the location ***,the developed microfluidic device with patterned microstructures can extend the application of in vitro cell culturing for future drug development and disease diagnosis.

摘要：Different treatments were conducted over Ti6Al4V samples in order to produce a surface modification to increase cell attachment and *** surface treatments evaluated in this study were as follows:etching with sulfuric acid/hydrochloric acid,oxidizing with hydrogen peroxide and low-pressure oxygen plasma *** contrast to other works found in the literature,this research conducts a comparison between different chemical and physical treatments in terms of different assays for surface characterization:X-ray diffraction,scanning electron microscope(SEM),energy-dispersive X-ray spectroscopy,water contact angle,release of vanadium ions and cell viability tests(MTT)of human osteoblasts(hFOB 1.19).Cell morphology over the different substrates was also studied by SEM *** was found that plasma and peroxide treatments increase the O/Ti ratio at the titanium surface and provide an increase in cell *** the other hand,acid etching provides a superhydrophilic surface which is not able to improve the cell attachment of human osteoblasts.

摘要：The asymptotic curve is widely used in astronomy, mechanics and numerical optimization. Moreover, it shows great application potentials in architecture. We focus on the problem how to cover bounded asymptotic curves by a freeform surface. The paper presents the necessary and sufficient conditions for quadrilateral with non-inflection being asymptotic boundary curves of a surface. And then, with given corner data, we model quintic Bezier asymptotic quadrilateral interpolated by a smooth Bezier surface of bi-eleven degree. We handle the available degrees of freedom during the construction to get an optimized result. Some representative surfaces bounded by asymptotic curves with lines or inflections are also discussed by examples. The presented interpolation scheme for the construction of tensor-product Bezier surfaces is compatible with the CAD systems.