摘要：An extended narrative dataset of the Medieval time AD 708-1426 in continental western Europe was set up. Some 30-year-moving mean seasonal temperature deviation series were reconstructed. A warming trend occurred around AD 1200. During the warm stage, seasonal cycle might be weak due to frequent cool summers. Significant warm summer conditions did not occur until the late 14th century, when the annual temperature level began decreasing. The mean warm season temperature level during the late 14th to the early 15th century might be about 0.3℃ higher than the present. It was suggested to cautiously comment on historical climates for different seasons.

摘要：在美国NCCN颁布的淋巴瘤治疗原则中CHOP方案（环磷酰胺、阿霉素、长春新碱、泼尼松）仍是侵袭性淋巴瘤一线治疗方案，其CR率为45％～53％，长期无病生存率为30％～37％。对于难治、复发病例，美国MDAnderson肿瘤中心比较了ESHAP、epoch、MINE几种三线方案的疗效，发现多数患者于2年内因治疗失败而死亡。近20年来，人们发现正常淋巴细胞生长发育过程中所需的一些重要的调节通路和因子在淋巴瘤的肿瘤生长中起着关键作用，以此为靶点设计的特异性靶向治疗新药与传统细胞毒药物相结合带来了肿瘤治疗的变革。我们将全面综述恶性淋巴瘤靶向治疗的新进展。

摘要：伴着美妙又粗犷的吉他声,聆听着歌者富有张力的嗓音,裙角飞扬中、眉宇顾盼间,舞者用热烈、极具感染力的舞姿将我们带入其中,使我们陶醉而难以自拔,这样不可抗拒的魅力只属于西班牙的国粹艺术——弗拉明戈。弗拉明戈的起源是一个充满争议的话题,因为关于它的文献记载只能追溯到过去的200年,而且"弗拉明戈"一词直到18世纪才开始使用——这个词被用来指这种歌曲和舞蹈,也被用来指演奏的吉他。在此之前,我们所知道的很多信息都来自家族内部世代相传的故事,就像弗拉明戈歌曲自身的流传方式一样。