摘要：A low-power IC for function electrical stimulation （FES） of nerves is designed for an implantable system and fabricated in CSMC＇s 0.6μm CMOS technology. The IC can be used for stimulating animals＇ spinal nerve bundles and other nerves connected with a cuff type electrode. It consists of a pre-amplifier,a main amplifier,and an output stage. According to the neural signal spectrum,the bandwidth of the FES signal generator circuit is defined from 1Hz to 400kHz. The gain of the circuit is about 66dB with an output impedance of 900. The 1C can function under a single supply voltage of 3-5V. A rail-to-rail output stage helps to use the coupled power efficiently. The measured time domain performance shows that the bandwidth and the gain of the IC agree with the design. The power consumption is lower than 6mW.

摘要：目的分析不同频率与时间的经穴经皮神经电刺激对电流感觉阈值(CPT)的影响。方法通过测量颏孔区和手臂区的电流感觉阈值评价经穴经皮神经电刺激的效用。对30例健康志愿受试者的合谷穴分次给予不同刺激时间和刺激频率的经皮神经电刺激,并测量同侧颏孔区和手臂区的电流感觉阈值。结果颏孔区电流感觉阈值升高。低频电刺激对慢痛(5 Hz CPT)有明显抑制作用(P<0.05),高频电刺激对快痛(250 Hz CPT)和慢痛均有抑制作用(P<0.05)。经皮神经电刺激的刺激频率(β=0.363)比刺激时间(β=0.274)对疼痛的抑制作用的影响更明显。结论经穴经皮神经电刺激确实可以影响特定反应区的感觉阈值,且治疗频率的选择比单纯延长治疗时间更为重要。