摘要：Rafiei et al recently described an association between the presence of the C150T polymorphism of the induc-ible nitric oxide synthase(iNOS)gene and Helicobacter pylori(***)induced gastric *** we used primer-BLAST to find the polymerase chain reaction (PCR)product that would be generated by the primers used by these authors no products against any of the sequences present in the GenBank database were *** analysis of the iNOS sequences present in the GenBank suggest that the result from their study might come from a faulty primer design and may thus represent an *** they may be correct and have identified a truly interesting explanation for the mechanism whereby *** induces gastric cancer but some additional experiments would be in order to exclude the possibility of a PCR artifact.

摘要：Nanomaterials have been applied as antibacterial agents by virtue of their unique functioning mechanism different from that of conventional *** oxide nanoparticles(CeO2 NPs)are important antibacterial agents due to their relatively low toxicity to normal cells and their distinct antibacterial mechanism based on the reversible conversion between two valence states of Ce(III)/Ce(IV).Some studies have been conducted to explore their antibacterial activities;however,systematic research reviews on the related mechanisms and influencing factors are still quite *** this review,we discuss the plausible mechanisms of the antibacterial activity of CeO2 NPs,analyze different influencing factors,and summarize various research reports on antibacterial effects on *** and *** also propose the potential applications and prospects,and hope to provide an in-depth understanding on the antibacterial mechanism and a better guidance to the design and applications of this promising antibacterial material in the future.

摘要：An effective cancer nanodrug not only needs to load a large fraction of pharmaceutical molecules and release them in responsive ways, to function as imaging and photothermal agents, but also needs to possess the favorable morphologies that are favored by the EPR effect of cancer tissues. In this study, we designed a spherical nanodrug by forming clusters using DOX and a polymer-engineered rGO. These spherical nanodrugs had a diameter of around 750 nm and assumed both functionalities of chemical therapy and the photothermal effect. In addition, this nanodrug featured a high-loading capability of DOX, a pH-responsive release profile, a self-fluorescent capability, and an effective accumulation in cancer cells. The layer-by-layer assembly of three cycles of polyethylene glycol (PEG) and polyacrylic acid (PAA) around the rGO core was indispensable in achieving a chemically-modified rGO precursor that assembled with DOX to produce the spherical nanodrug. The spherical nanodrug effectively decreased cell viability upon NIR irradiations.

摘要：CuS-graphene oxide/TiO2 composites were prepared using a sol-gel method to improve the photocatalytic performance of the photocatalyst. The composites were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analysis, and transmission electron microscopy. The photocatalytic activities were examined by the degradation of methylene blue (MB) under visible-light irradiation. The photodegradation of MB under visible-light irradiation reached 90.1% after 120 min. The kinetics of MB degradation was plotted alongside the values calculated from the Langmuir-Hinshelwood equation. The CuS-graphene oxide/TiO2 sample prepared using 0.2 mol of TiO2 showed the best photocatalytic activity. This was attributed to a cooperative reaction as a result of increased photoabsorption by graphene oxide and an increased photocatalytic effect by CuS.

摘要：Lithium nickel manganese oxide spinel(Li Ni0.5-Mn1.5O4, LNMO) has attracted much attention as the cathode material for rechargeable lithium-ion batteries due to its high energy density and low cost. However, the short cycle life and poor high-rate capability hinder its commercialization. In this study, we synthesized hollow spherical LNMO built from polyhedral particles. The LNMO hollow structure guarantees sufficient contact with electrolyte and rapid diffusion of lithium ions. To enhance the conductivity, we use carbon nanotubes(CNTs) to modify the surface of the cathode. After CNT modification, the LNMO hollow structure manifests outstanding cycling stability and high-rate capability. It delivers a discharge capacity of 127 m A h g-1 at 5 C, maintaining 104 m A h g-1 after 500 cycles. Even at a high rate of 20 C, a capacity of 121 m A h g-1 can be obtained. The excellent electrochemical performance is ascribed to the unique structure and the enhanced conductivity through CNT modification. It is demonstrated that the CNTmodified hollow spherical LNMO is a promising cathode for lithium ion batteries.

摘要：Purpose:Venlafaxine hydrochloride sustained release formulation increases patient compliance by reducing frequency of administration and it also reduces side effects like nausea and vomiting. Hence the objective of present investigation was to develop triple layer sustained release tablets of venlafaxine HCl using xanthan gum or polyethylene oxide. Methods:The venlafaxine HCl 150 mg sustained release tablets were prepared by wet granulation technique where drug was incorporated in middle layer with part of polymer. The barrier layers were composed of remaining polymer and other excipients. The granules and tablets were characterised. Optimized batches were also tested for drug release at different pH and in presence of ethanol, for kinetics of drug release and for water uptake/swelling. Results: Preliminary trials of monolayer tablet showed burst release due to high dose and solubility of venlafaxine HCl and hence triple layer tablets were developed. Granules of middle layer exhibited good flow properties. The comparative drug release to Effexor? XR capsule 150 mg could be achieved by modulating the concentration of polymer and diluents in middle layer as well as in barrier layers. Higher amount of polyethylene oxide was required as compared to xanthan gum which may be due to high water uptake and poor gel strength of polyethylene oxide. The optimized formulations showed pH independent drug release as well as ethanol had no effect on drug release. Effexor? XR capsule and optimized batches followed Weibull kinetics for drug release. The radar diagrams showed the comparable drug release to innovator in both the optimized formulations but point to point correlation was observed in batch with xanthan gum. Conclusion: The layered matrix tablets formulated successfully using hydrophilic polymers, xanthan gum or polyethylene oxide, to sustain the release of highly soluble drug like venlafaxine HCl.

摘要：本文主要论述了活性氧化钙回转窑煅烧工艺优化设计原理,优化设计总体思路,工艺流程,技术创新点,实现的经济效益等。

摘要：在研究并联开关接入电抗式故障电流限制器(fault current limiter,FCL)的基础上,给出一种新型的基于快速开关的FCL,论述该类型FCL中快速真空开关、可关断晶闸管(gate turn-off thyristor,GTO)及金属氧化物避雷(metal oxide arrester,MOA)的性能要求及设计原则,依据过电压绝缘配合的要求设计MOA的参数,仿真分析该类型FCL的短路电流转移过程及限流效果,最后从限流特性、经济性、可靠性等方面与现有串谐式FCL及固态限流器进行对比分析。

摘要：根据CMOS探测器噪声的特点,针对传统降噪方法较难去除的时间相关噪声提出了一种降噪的新算法。对算法进行了原理分析,介绍了该算法基于FPGA硬件实现的新方法。最后,通过实验结果,对该算法的效果进行了评价。

摘要：针对高分辨率成像冰川厚度探测雷达设计了一款VHF波段宽带高功率线性放大器。以硅VDMOS器件作为功放管,采用推挽结构和传输线变压器阻抗变换网络相结合的方法,实现了50MHz～200MHz频带范围内80W线性功率输出。该放大器由四级级联组成,每一级均采用ADS作负载牵引仿真确定最佳负载阻抗并用负反馈技术确保增益平坦。测试结果表明,1dB压缩点输出功率为80W,增益54dB,附加效率40%,谐波小于-30dBc。