摘要：The construction of engineered neural tissue using cell-derived extracellular matrix(ECM)-modified scaffolds is a promising *** fibroin(SF)sponge is an advantageous scaffold for the construction of engineered neural tissues,but it can still be modified to enhance its *** mouse embryonic fibroblasts(MEFs)are proven that they can secrete amounts of ECM and soluble factors including neurotrophic ***-derived ECM is expected to improve the activity of the *** we aimed to construct 3D functional neural tissues based on MEFs-derived ECM modified SF *** were cultured on porous SF sponges and decellularized with Triton X-100 and *** decellularized ECM deposited scaffolds were characterized through scanning electron microscopy and confocal *** efficiency of decellularization was evaluated by quantifying remaining ***,we investigated the primary cortical neuronal growth and 3D neural network formation effect on MEFs-derived ECM modified SF *** to bare SF sponges,ECM-SF sponges showed improved neuronal growth and axon extension indicated by immunofluorescence staining and ***,ECM-SF sponges showed increased 3D neural network formation with functional ***,this study demonstrated that functionalization of SF scaffolds using cell-derived ECM could improve the bioactivity of SF materials and provide an ideal microenvironment for functional neural tissue formation.

摘要：Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high *** this work,an artificial tactile perception system with integrated sensing,storage,and computing functions is designed based on silk fibroin composite memristors and piezoresistive pressure *** sensors based on polydimethylsiloxane/silver nanowires can sense the external pressure stimulation with fast response *** addition,the composite memristor based on silk fibroin possesses good cyclic stability and synaptic plasticity simulation and acts as an artificial synapse to process tactile *** a result,the integrated tactile perception system realizes the perception,storage,and processing of pressure information,demonstrating the possibility to simulate the biological tactile perception nervous *** type of system may promote potential applications in artificial intelligence,such as autonomous driving,wearable,flexible electronic devices,and bionic robots.