摘要：目的胫骨的 pilon 破裂仍然保持挑战性让一位整形外科的外科医生修理。外部固定(ExFix ) 和内部固定(ORIF ) 是为修理胫骨的 pilon 破裂的二个广泛地使用的方法。然而，考虑方法是优异的比较研究的结论是争论的。我们的目的是比较 ORIF 和 ExFix 并且澄清哪个方法以减小和联合结果和主要复杂并发症更好。方法 A 计算机化 MEDLINE， EMBASE， Springer，和 Cochrane 图书馆的研究(在 2014 年 12 月前) 为比较的任何设计的研究， ORIF 和 ExFix 被进行。加权的吝啬的差别(WMD ) ，风险比率(RR ) 并且相应 95% 信心间隔(CI ) 被用于估计二个方法的效果。统计分析用评论经理版本 5.2 被做。十个队学习的结果和结果使随机化临床的试用在我们的最终的分析被包括。并且分析没在深感染发现二个方法之间的重要差别(p = 0.13 ) ，减小(p = 0.11 ) ，临床的评估(p = 0.82 ) ， traumatic 以后关节(p = 0.87 ) ，并且联合时间(p = 0.35 ) 。而且， ExFix 组被发现有表面的感染的更高的率(p = 0.001 ) ， malunion (p = 0.01 ) 并且不属于工会(p = 0.02 ) ，但是有意外硬件移动的更低的风险(p = 0.0002 ) 。我们建议那 ORIF 的结论有表面的感染的相对更低的发生率， malunion 并且不属于工会，但是意外硬件的更高的率移动。没有差别在深感染，减小，临床的评估， traumatic 以后关节和联合时间被发现。

摘要：Recently,organ-on-chips have become a fast-growing research field with the widespread development of microfluidic chips and synthetic materials in tissue *** to the existing cardiotoxicity of many cardiovascular drugs,heart-onchips which are promising to replace traditional animal models have been extensively researched and developed to mimic human organ functions in *** heart-on-chips mainly focus on cardiac mechanics,which is regarded as the central indicator of in vitro heart models and drug *** methods for the detection of myocardial mechanics have been demonstrated complex and inefficient in ***,photonic crystal materials with unique optical properties have attracted interests and have been introduced into the heart-on-chips,developing a visualized self-reporting system for cardiomyocytes activity *** this review,photonic crystal-based heart-on-chips for biosensing are introduced,as well as the fabricationmethods and design criteria of *** characterizations of the photonic crystal materials are classified into optical properties and structural properties,and their applications in cell culture and biosensing are further ***,several representative examples and developments of the integration of photonic crystal materials into microfluidic chips are described in ***,potentials and limitations are put forward to promote the development of the photonic crystal-based intelligent heart-on-chips.

摘要：Drug resistance is one of the major obstacles in the drug therapy of *** in this area in pre-clinical research have focused on developing novel platforms to evaluate and decrease drug *** this paper,inspired by the structure of hives where swarms live and breed,we propose porous hydrogel arrays with a uniform pore structure for the generation of hepatoma cell spheroids and the investigation of drug *** porous hydrogel arrays were fabricated using polyeth-ylene glycol diacrylate(PEGDA)hydrogel to negatively replicate a well-designed *** from the elaborate processing of the template,the prepared porous hydrogel arrays possessed a uniform pore *** to their anti-adhesion properties and the excellent biocompatibility of the PEGDA hydrogel,the hepatoma cells could form well-defined and uni-form hepatoma cell spheroids in the porous hydrogel *** found that the resistant hepatoma cell spheroids showed more significant Lenvatinib resistance and a migratory phenotype compared with a two-dimensional(2D)cell culture,which reveals the reason for the failure of most 2D cell-selected drugs for in vivo *** features give such porous hydrogel arrays promising application prospects in the investigation of tumor cell spheroid culture and in vitro drug resistance.

摘要：To create a scaffold that is suitable for the construction of tissue-engineered skin, a novel asymmetric porous scaffold with different pore sizes on either side was prepared by combining a collagen-chitosan porous membrane with fibrin glue. Tissue-engineered skin was fabricated using this asymmetric scaffold, fibroblasts, and a human keratinocyte line (HaCaT). Epidermal cells could be seen growing easily and achieved confluence on the fibrin glue on the upper surface of the scaffold. Scanning electron microscopy showed typical shuttle-like fibroblasts adhering to the wall of the scaffold and fluorescence microscopy showed them growing in the dermal layer of the scaffold. The constructed composite skin substitute had a histological structure similar to that of normal skin tissue after three weeks of culture. The results of our study suggest that the asymmetric scaffold is a promising biologically functional material for skin tissue engineering, with prospects for clinical applications.

摘要：目的:总结针灸治疗高脂血症的临床研究进展,以发现存在的问题,指导今后的研究方向。方法:计算机检索科技期刊数据库,得到近10年针灸治疗高脂血症的相关文献并进行综合分析。结果与结论:符合纳入标准的42篇文献,主要涉及针刺、灸法、针灸并用、穴位埋线、穴位敷贴、穴位注射等疗法,多取脾胃经的穴位为主穴。但针灸辨证取穴、针刺补泻手法的应用及试验方案的设计方面有待改进。

摘要：目的旨在调查老年缺血性脑卒中住院患者口腔健康现状并分析影响因素,为制订该人群口腔健康管理策略提供参考依据。方法采用横断面调查,于2022年1一6月选取重庆市2所三级甲等医院的350例老年缺血性脑卒中患者,采用巴氏指数(Barthel Index,BI)、进食评估工具(Eating Assessment Tool-10,EAT-10)和口腔健康评估量表(Oral Health Assessment Tool,OHAT)分别调查研究对象的自理程度、吞咽功能和口腔健康状况,采用自行设计的调查表调查人口统计学、疾病相关信息及口腔健康行为。采用二元logistic回归分析进行相关影响因素分析。结果共纳人346例老年缺血性脑卒中患者,其中男性199例,女性147例。0HAT总得分中位数为5分(总得分范围0~16分)。龋齿(91.7%,278/303)和口腔清洁不良(92.2%,319/346)为该人群主要的口腔健康问题。二元logistic回归分析结果显示,性别、血脂水平、脑卒中发生次数和严重程度、口腔健康行为、自理程度为该人群口腔健康的影响因素(P<0.05)。结论医务人员应加强老年缺血性脑卒中患者口腔健康评估,并针对高危人群的特点实施个性化的健康教育和管理措施,促进其口腔健康。

摘要：For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue ***,the oxygen in our environment is vital for *** a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen,photosynthesis has been widely studied in scientific research and used in production of food,fuel,and *** recent years,photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy,tissue regeneration,transplantation,and in treatment of specific *** review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.

摘要：目的克罗恩病因其无法治愈及肠道症状特点,不可避免地影响了患者生活,并可能导致病耻感。本研究旨在调查克罗恩病患者病耻感的现状及影响因素。方法采用便利抽样的方法,于2020年10月至2021年3月对广州市某三级甲等医院消化内科病房的146例克罗恩病患者进行问卷调查。采用自行设计的一般资料问卷、社会影响量表(Social Impact Scale,SIS)、炎症性肠病自我效能量表(Inflammatory Bowel Disease-Self-Eficacy Scale,IBD-SES)及社会支持评定量表(Social Support Rating Scale,SSRS)分别对克罗恩病患者的一般资料、病耻感现状、自我效能和社会支持水平进行调查。采用多重线性回归分析对克罗恩病患者病耻感的影响因素进行分析。结果克罗恩病患者病耻感得分为(58.14±10.74)分,处于中等水平。85.6%(125/146)的克罗恩病患者存在中重度的病耻感。多重线性回归分析结果显示,患者感知到的社会公众对疾病的了解情况、家庭人均月收入、年龄、自我效能为克罗恩病患者病耻感的影响因素,可解释病耻感总变异的52%。结论绝大部分克罗恩病患者存在中重度的病耻感。感知到的社会公众对疾病的了解少、家庭人均月收入低、年龄≥40岁、自我效能低的克罗恩病患者表现出更高程度的病耻感。

摘要：The organized alignment of cells in various tissues plays a significant role in the maintenance of specific *** induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of natural *** structures that guide cell orientation are used to facilitate tissue regeneration and *** here review how various aligned structures are fabricated,including aligned electrospun nanofibers,aligned porous or channeled structures,micropatterns and combinations thereof,and their application in nerve,skeletal muscle,tendon,and tubular dentin *** future use of aligned structures in tissue engineering is also discussed.

摘要：Cardiovascular diseases are the leading cause of morbidity and mortality throughout the world underlining the importance of efficient treatments including disease modeling and drug discovery by cardiac tissue ***,the predictive power of these applications is currently limited by the immature state of the ***,we developed gelatin hydrogels chemically crosslinked by genipin,a biocompatible crosslinker,as cell culture *** rat cardiomyocytes appear synchronous beatingwithin 2 days after seeding on ***,we applied the electrical stimulation as a conditioning treatment to promote the maturation of cardiomyocytes cultured on the *** results show that electrical stimulation improves the organization of sarcomeres,establishment of gap junctions,calcium-handling capacity and propagation of pacing signals,thereby,increase the beating velocity of cardiomyocytes and responsiveness to external *** above system can be applied in promoting physiological function maturation of engineered cardiac tissues,exhibiting promising applications in cardiac tissue engineering and drug screening.