摘要：在在心肺的复活( CPR )以后恢复自发的循环并且验证它两个都结果容易地可得到、预兆的 *** 变量的无知觉的幸存者开发能够早、确切预言的各种各样的结果的一个工具的目的被系统地在 resuscitation.A 上考察出版文学识别价值被分到使用的这些 *** 在有 APACHE /score 到的联合的这些变量设计 multifactorial 预言

摘要：Objective: This study aimed to evaluate Chinese tertiary hospital nurses' research output,research ability,and their related training needs regarding scientific research methodology and analyze the relations among ***: A nationwide survey was conducted in China on a large sample of tertiary hospital nurses (n =27,335) recruited from 22 provinces,autonomous regions,and municipalities.A validated,self-designed questionnaire,consisted of a common questionnaire,the Science Research Skills Self-Rating Questionnaire (SRSQ) and the Scientific Research Training Needs Questionnaire (SRTNQ) were used to assess nurses' research output,self-rated research skills and research-training ***: The nurses' scientific research participation rates (with 4.13%,7.85%,5.35%,and 2.04% in research projects,research attendance,papers published,and patent,respectively) and their self-rated research skills 25.00 (12.50,37.50) were very ***,the research training needs were relatively high 53.12(37.50,75.00).Significant differences in research participation rates (research projects,research attendance,papers published,and patent),scientific research skills,and research-training needs were determined by age,highest education level,nursing experience,employment,technical title,administrative post,and clinical tutoring experience (P< 0.05).Female and male nurses had different research participation rates (only research projects and studies published) and scientific research skills (P < 0.05).Positive correlations were observed among research output,scientific research skills,and researchtraining needs (P < 0.01).Conclusions: Nurses' scientific research participation and self-rated research ability were below the optimal despite that they had relatively high research-training *** should be provided further research training with tailored content to their characteristics and capacity.

摘要：As an emerging technology to promote the combination of medicine and industry,the three-dimensional(3D)printing has developed rapidly in the fields of orthopedics,while its unique advantages in improving precise treatment still need to be further *** this report,our team have exhibited several classic cases of integrating 3D printing into orthopedic clinical application,thereby further elaborating thoughts and opinions on the significance of 3D printing in the orthopedic clinical application,technical advantages,existing main problems and coping strategies.

摘要：网络药理学是基于系统生物学理论和生物系统网络分析来设计药物的一门新兴学科。它综合探索药物对疾病网络的干预和影响,揭示多分子药物协同治疗疾病的奥秘。这些概念反映了多组分、多靶点和系统调控的思想,与中医辨证论治的研究思路有许多相似之处,强调对病因病机的全面认识。网络药理学可以用来预测和鉴别中药的靶标和有效成分,阐明其作用机制,系统地解释处方的用药规律,探索真实世界处方的规律,发现新的适应症和新的活性化合物,研究药物重新定位等。本文系统总结了网络药理学在中药研究中的应用,展示了网络药理学在中药研究中的重要价值。

摘要：Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent *** the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in ***,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment *** study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study.

摘要：Abstract：Objective: To assess the medical community's awareness and practice regarding delirium in the intensive care unit (ICU). Methods: One hundred and ten predesigned questionnaires were distributed to ICU practitioners in the affiliated hospitals of Zhejiang University. Results: A total of 105 valid questionnaires were collected. Totally, 55.3% of the clinicians considered that delirium was common in the ICU. Delirium was believed to be a significant or serious problem by 70.5% of respondents, and under-diagnosis was acknowledged by 56.2% of the respondents. The incidence of ICU delirium is even more under-estimated by the pediatric doctors compared with their counterparts in adult ICU (P<0.05). Primary disease of the brain (agreed by 82.1% of the respondents) was believed to be the most common risk factor for delirium. None of the ICU professionals screened delirium or used a specific tool for delirium assessment routinely. The vast majority (92.4%) of respondents had little knowledge on the diagnosis and the standard treatment of ***: Although delirium is considered as a serious problem by a majority of the surveyed ICU professionals, it is still under-recognized in routine critical care practice. Data from this survey show a disconnection between the perceived significance of delirium and the current practices of monitoring and treatment in ICU in China。

摘要：AIM:To investigate a newly designed stent and its dilatation effect in a rabbit model of benign esophageal ***:Thirty-four New Zealand white rabbits underwent a corrosive injury in the middle esophagus for esophageal stricture *** rabbits with a successful formation of esophageal strictures were randomly allocated into two *** control group(n = 15) was implanted with a conventional stent,and the study group(n= 15) was implanted with a detachable "pieced" *** study stent(30 mm in length,10 mm in diameter) was composed of three covered metallic pieces connected by surgical suture *** stent was collapsed by pulling the suture lines out of the *** weeks after stricture formation,endoscopic placement of a conventional stent or the new stent was *** extraction was carried out four weeks *** extraction rate,ease of extraction,migration,complications,and survival were ***:Stent migration occurred in 3/15(20%)animals in the control group and 2/15(13%) animals in the study group;the difference between the two groups was not statistically *** the end of four weeks,the remaining stents were successfully extracted with the endoscope in 100%(11/11) of the animals in the study group,and 60%(6/10)of the animals in the control group;this difference was statistically significant(P < 0.05).There was no difference in the mean number of follow-up days between the control and study groups(25.33 vs25.85).Minor bleeding was reported in five cases in the study group and four in the control *** were no severe complications directly associated with stent implantation or extraction in either of the two ***:In this experimental protocol of benign esophageal strictures,the novel "pieced" stent demonstrated a superior removal rate with a similar migration rate compared to a conventional stent.

摘要：Aim:The correction of nasal tip defects presents many ***’s bilobed flap has been widely used for such repairing defects,but may be complicated by interrupted scars on the nasal *** study evaluates the design principles,results,and advantages of a modified bilobed flap for repairing nasal tip ***:The primary lobe was located between the defect and the cheek,and the second lobe was located in the *** width of the primary lobe was equal to that of the primary *** length of the primary lobe was 10%longer than the distance of the distal defect edge to the pivot point of the *** length of the second lobe was 30%longer than the distance of the distal defect edge to the pivot point of the *** width of the second lobe was 90-100%of that of the primary *** ability to close the defect under minimal tension,the cosmetic appearance,and any complications were ***:This technique was performed in 34 cases;defect size ranged from 0.8 cm×0.9 cm to 1.2 cm×1.8 *** defects were closed under minimal wound tension,all scars were inconspicuous,no obvious complications occurred,and the aesthetic outcomes were considered ***:The modified bilobed flap can provide satisfying outcomes with lower morbidity and inconspicuous *** is simple and suitable for repairing small-to medium-sized defects in the nasal tip.

摘要：嗜酸粒细胞性胰腺炎(EP)是一种非常罕见的疾病,单纯由胰腺嗜酸性粒细胞浸润引起。EP容易被误诊为胰腺癌,给患者造成不必要的经济负担和身体伤害。2017年至今,我们报告了3例EP病例,均通过类固醇治愈,未出现复发。我们回顾性分析了3例患者的临床表现、血清学表现、影像学特点(超声、CT和MRI)、病理诊断及治疗,并对其进行了电话随访。此外,在Web of Science和PubMed数据库上使用与EP相关的关键词进行了文献检索,并纳入了不受出版日期或语言限制的病例报告。我们对最终共纳入的19例病例进行了分析,并明确了EP的诊断标准。我们提出的EP诊断流程可以很好地对EP进行诊断。希望我们的诊断标准和诊断流程能够降低EP误诊率,以提高临床诊治水平。同时,我们也期望通过更多的EP病例来检验我们提出的诊断标准,并设计出一个更为系统的诊断流程图。