摘要：Autologous bone marrow-derived mesenchymal stem cells(BMSCs)have been shown to promote osteogenesis;however,the effects of allogeneic BMSCs(allo-BMSCs)on bone regeneration remain ***,we explored the bone regeneration promotion effect of allo-BMSCs in 3D-printed autologous bone particle(ABP)***,we concurrently printed scaffolds with polycaprolactone,ABPs,and allo-BMSCs for appropriate support,providing bioactive factors and seed cells to promote *** vitro studies showed that ABP scaffolds promoted allo-BMSC osteogenic *** vivo studies revealed that the implantation of scaffolds loaded with ABPs and allo-BMSCs into canine skull defects for nine months promoted *** experiments suggested that only a small portion of implanted allo-BMSCs survived and differentiated into vascular endothelial cells,chondrocytes,and *** implanted allo-BMSCs released stromal cell-derived factor 1 through paracrine signaling to recruit native BMSCs into the defect,promoting bone *** study contributes to our understanding of allo-BMSCs,providing information relevant to their future application.

摘要：AIM： To present the rationale, design, methodology, and the baseline data of the beijing Desheng Diabetic Eye Study（BDDES）, and to determine the prevalence of diabetic retinopathy（DR） and possible risk factors in patients with type 2 diabetes mellitus（T2DM） in an urban community of beijing, ***： Community-based prospective cohort study of persons diagnosed with T2DM aged 30 y or older. The main variables of interest are the presence and progression of DR as determined by the standardized ETDRS grading of seven fields fundus photographs. The presence and severity of DR were analyzed for possible correlations to non-genetic and genetic ***： A total of 1438 participants with data available for analysis, the prevalence of any DR was 35.4%. The prevalence of mild non-proliferative diabetic retinopathy（NPDR）, moderate NPDR, severe NPDR, and proliferative diabetic retinopathy was 27.7%, 2.6%, 0.5% and 4.5%, respectively. By multiple logistic regression analysis, risk factors for the presence of any DR included male（P=0.031）, lower income level（P=0.011）, lower education background（P=0.022）, longer duration of diabetes（P=0.001）, younger age at diabetic onset（P=0.001）, higher systolic blood pressure（P=0.007）, higher glycosylated hemoglobin A1 c levels（P=0.001）, high albuminuria（P=0.03）, and use of insulin（P〈0.001）. For vision-threatening DR, four factors were significant： younger age at diabetic onset（P〈0.001）,higher systolic blood pressure（P=0.042）, high albuminuria（P〈0.001）, and use of insulin（P〈0.001）. CONCLUSION： The BDDES is the first large-scale ongoing cohort study of a Chinese urban population of persons with type 2 diabetes. Using standardized grading system comparable to large cohort studies from western populations, our baseline data shows that the prevalence of DR and major risk factors in this Chinese ethnic population are comparable to that found in the western population studies.

摘要：Background:Handan Eye Study (HES),a large population-based cohort study in rural area of northern China,was one of the few studies focusing on the major eye diseases of rural Chinese *** aim of this study was to introduce the design,methodology and to assess the data quality of the follow-up phase of ***:All participants were recruited in Yongnian county of Handan city between 2012 and *** outcomes were measured by visual quality scales and ocular *** performed the Chi-square test to make comparison of categorical data among groups,One-way analysis of variance and Kruskal-Wallis test was applied to make comparison of continuous data among groups,a post-hoc test was done to make further pairwise ***-class correlation coefficients (ICCs) and Kappa coefficients were used to evaluate the consistency between different *** regression was used to explore the influence factors of death,odds ratio (OR) and 95% confidence interval (CI) were used to estimate the effect size of each influence ***:The follow-up rate was 85.3%.Subjects were classified into three groups:the follow-up group (n =5394),the loss to follow-up group (n =929),and the dead group (n =507),comparison of their baseline information was *** with the other two groups,age of the dead group (66.52 ± 10.31 years) was the oldest (Z =651.293,P < 0.001),male proportion was the highest (59.0 %)(x2 =42.351,P < 0.001),only 65.9 % of the dead finished middle school education (Z =205.354,P < 0.001).The marriage percentage,body mass index (BMI),best-corrected visual acuity (BCVA),and intra-ocular pressure of the dead group was the lowest *** equivalent error (SER) of the dead group was the ***,history of smoking,hypertension,diabetes,and heart disease were more common in the dead *** analysis showed that age (OR =1.901,95% CI:1.074-1.108),gender (OR =0.317,95% CI:0.224-0.448),and BCVA (OR =0.282,95%

摘要：Objectives:This study aims to develop the Directive and Nondirective Support Scale for Patients with Type 2 Diabetes(DNSS-T2DM)to measure diabetes-specific support and patients’preference as well as evaluate the construct validity and reliability of the ***:A cross-sectional study was conducted in Tongzhou District,beijing,China from July to September 2015.A total of 474 participants who had been diagnosed as type 2 diabetes by physicians and completed the DNSS-T2DM were *** original 11-item DNSS-T2DM contains five items on nondirective support(Items 1-5)and six items on directive support(Items 6-11).There were two parallel questions for each item with one to measure the preference for support(Preference part)and the other to measure the perception of support in reality(Reality part).The final DNSS-T2DM was determined based on the results of the exploratory factor analysis(EFA).The construct validity of the final DNSS-T2DM was evaluated by the confirmatory factor analysis(CFA).The reliability was evaluated by internal consistency with Cronbach’sα***:A final 7-item DNSS-T2DM loaded on 2 factors with four items representing nondirective support and three items representing directive support was determined based on the *** CFA indicated a satisfactory construct *** internal consistency of the 7-item DNSS-T2DM as well as the nondirective support items was satisfactory with Cronbach’sα≥***:Our study supported the validity and reliability of the 7-item *** studies on the application of the DNSS-T2DM in different settings and population are needed.

摘要：智能仿生软材料是近年来科学研究的重点之一.液晶高分子材料是众多软材料中最有发展潜力的材料之一.目前通过液晶高分子材料制备具有复杂功能和多种响应的仿生器件主要通过两种方法,其一是引入多种响应性基团,赋予材料多重响应.另一个是构建单一刺激下具有变形变色协同功能的材料.然而,结合这两种策略,构建既具有多重刺激响应,又能协同变形变色的新型液晶高分子仍然是一个挑战.为此,本工作通过结合光响应性液晶网络和亲水的聚(2-羧乙基丙烯酸酯共丙烯酸)层(PC),制备了一种光和湿度双重响应的软驱动器.在紫外光的驱动下,偶氮苯的分子异构驱动复合薄膜的各向异性形变.环境湿度的变化能使亲水的PC层发生溶胀和脱水,使薄膜发生另一模式的形变.由于薄膜内部荧光分子与水分子的协同作用,PC膜的荧光强度增强.由于整合了双重响应性和协同行为,这种新型的双响应驱动器在制造智能软体机器人方面具有较大的潜力.通过合理的设计,我们制备了一个光驱动的智能软体机器人.该机器人表现出检测水、改变运动模式和荧光强度的能力,在构筑具有识别、响应和自我调整能力的多功能软体机器人方面具有实际应用潜力.