摘要：具有共价适应性网络的聚氨酯弹性体(PU-CANs)因其具有再加工性、自适应性和自愈合性而引起了人们的广泛关注.然而氨基甲酸酯的键能通常较高,在低温下实现其优异的动态性能仍然是一项艰巨的挑战.针对以上问题,基于动态性能可调范围广的酚氨基甲酸酯键,我们成功设计并制备了一种具有CANs的氟化聚酚氨酯弹性体(FPPU),系统地研究了氟原子对弹性体力学性能、热学性能、可再加工性、自愈性、表面自由能及疏水性的影响.和非氟化的聚酚氨酯弹性体(APPU)相比,FPPU表现出缺口不敏感性、自愈合效率高(98%)、动态解离温度低(60℃)、优异的可再加工性和低表面能(62 MJ m^(-2)).基于上述优点,FPPU被选为弹性基底,用于组装自供电的摩擦纳米发电机(TENG).该TENG具有优良的电输出性能,开路电压的峰值为103 V,短路电流的峰值为4.7μA,短路电荷的峰值为43 nC.此外,TENG还具有良好的自清洁性和再加工性.更进一步地,基于FPPU构建了面向柔性电子器件的可拉伸和自愈合复合导体.

摘要：Rapid formation of a continuous endothelial cell(EC)monolayer with healthy endothelium function on the luminal surface of vascular implants is imperative to improve the longtime patency of small-diameter vascular *** the present study,we combined the contact guidance effects of aligned nanofibers,which enhance EC adhesion and proliferation because of its similar fiber scale with native vascular basement membranes,and aligned microfibers,which could induce EC elongation effectively and allow ECs *** was followed by successive immobilization of collagen IV and laminin to fabricate a biomimetic basement membrane(BBM)with structural and compositional *** hemolysis assay and platelet adhesion results showed that the BBM exhibited excellent ***,the adhered human umbilical vein endothelial cells(HUVECs)onto theBBMaligned along the orientation of the microfibers with an elongated morphology,and the data demonstrated that the BBM showed favorable effects on EC attachment,proliferation,and *** oriented EC monolayer formed on the BBM exhibited improved antithrombotic capability as indicated by higher production of nitric oxide and prostacyclin(PGI2).Furthermore,fluorescence images indicated that HUVECs could infiltrate into the BBM,implying theBBM’s ability to enhance transmural ***,theBBMpossessed the properties to regulate ECbehaviors and allow transmural ingrowth,demonstrating the potential to be applied as the luminal surface of small-diameter vascular implants for rapid endothelialization.

摘要：人工血管的成功取决于多种因素,包括材料的化学、物理性质和结构设计。本文通过回顾人工血管的历史发展和作者的一些工作,在一定程度上总结过去的经验,希望对人工血管的进一步发展能够有所帮助。