摘要：As the demand for energy continues to increase, shale gas, as an unconventional source of methane （CH4）,shows great potential for commercialization. However, due to the ultra-low permeability of shale gas reser-voirs, special procedures such as horizontal drilling, hydraulic fracturing, periodic well shut-in, and carbondioxide （C02） injection may be required in order to boost gas production, maximize economic benefits, andensure safe and environmentally sound operation. Although intensive research is devoted to this emergingtechnology, many researchers have studied shale gas design and operational decisions only in isolation. Infact, these decisions are highly interactive and should be considered simultaneously. Therefore, the researchquestion addressed in this study includes interactions between design and operational decisions. In thispaper, we first establish a full-physics model for a shale gas reservoir. Next, we conduct a sensitivity analysisof important design and operational decisions such as well length, well arrangement, number of fractures,fracture distance, C02 injection rate, and shut-in scheduling in order to gain in-depth insights into the com-plex behavior of shale gas networks. The results suggest that the case with the highest shale gas productionmay not necessarily be the most profitable design; and that drilling, fracturing, and CO2 injection have greatimpacts on the economic viability of this technology. In particular, due to the high costs, enhanced gas re-covery （EGR） using CO2 does not appear to be commercially competitive, unless tax abatements or subsidiesare available for CO2 sequestration. It was also found that the interactions between design and operationaldecisions are significant and that these decisions should be optimized simultaneously.