摘要：Nucleocapsid(N) protein plays crucial roles in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), including the formation of ribonucleoprotein(RNP) complex with the viral *** we reported the crystal structures of the N-terminal domain(NTD) and C-terminal domain(CTD) of the N protein and an NTD-RNA complex. Our structures reveal a unique tetramer organization of NTD and identify a distinct RNA binding mode in the NTD-RNA complex, which could contribute to the formation of the RNP complex. We also screened small molecule inhibitors of N-NTD and N-CTD and discovered that ceftriaxone sodium, an antibiotic, can block the binding of RNA to NTD and inhibit the formation of the RNP complex. These results together could facilitate the further research of antiviral drug design targeting N protein.

摘要：Adsorption and activation of dinitrogen(N_(2)) is an indispensable process in nitrogen *** nitride species continue to attract attention as a promsing catalyst for ammonia ***,the detailed mechanisms at a molecular level between reactive nitride species and N_(2) remain unclear at elevated temperature,which is important to understand the temperature effect and narrow the gap between the gas phase system and condensed phase ***,the ^(15)N/^(14)N isotopic exchange in the reaction between tantalum nitride cluster anions Ta_(3)^(14)N_(3)^(-) and ^(15)N_(2) leading to the regeneration of ^(14)N_(2)/^(14)N^(15)N was observed at elevated temperature(393-593 K)using mass *** the aid of theoretical calculations,the exchange mechanism and the effect of temperature to promote the dissociation of N_(2) on Ta_(3)N_(3)^(-) were elucidated.A comparison experiment for Ta_(3)^(14)N_(4)^(-)/^(15)N_(2) couple indicated that only desorption of ^(15)N_(2) from Ta_(3)^(14)N_(4)^(15)N_(2)^(-) took place at elevated *** different exchange behavior can be well understood by the fact that nitrogen vacancy is a requisite for the dinitrogen activation over metal nitride *** study may shed light on understanding the role of nitrogen vacancy in nitride species for ammonia synthesis and provide clues in designing effective catalysts for nitrogen fixation.

摘要：Cholesteric liquid crystal(CLC)particles can adaptively respond to constant changes in external stimuli and thus are widely used in solvent-sensing,pattern fabrication,and *** studies discussed the color change at the center of the particles for various ***,few studies analyzed the color change of the brush structure of particles in response to various applications because of the complicated birefringence *** this paper,we present a novel integrated sensing system based on the synergetic color change from the center and the brush structure of CLC *** system provides abundant and additional sensing information relative to the traditional *** particles are prepared by mixing reactive mesogens,a reactive chiral dopant,a non-reactive LC molecule,and a photoinitiator by using a microfluidic device and subsequent *** CLC particles exhibit gorgeous color at the center and brush structure upon various solvent stimuli because of the Bragg reflection and the birefringence effect,which is explained by the possible color-changing mechanism introduced in this *** proof-of-concept applications,such color-changing polymer particles are demonstrated in multi-solvent-sensing detection and pattern *** study provides new insights into the development of stimuli-responsive advanced functional materials with tailorable nanostructures toward technological applications ranging from sensing to display.

摘要：In this study,TiNCl was designed and applied in high-rate lithium-ion batteries(LIBs),and the mechanism of the energy storage in TiNCl was *** Ti-N layer serves as the electronic conductive unit for its high conductivity,while the polyhedral channels constructed with Cl facilitate the transmission of Li ions serving as the ionic conductive *** addition,due to the negatively charged nature of Cl,the TiNCl anode has a capacitive contribution up to 99.5%at 1 mV *** at a high rate of 50 C,it still retains a remarkable reversible capacity of 202 mA h gafter 1000 *** concept based on the structure design develops new electrode materials with desired properties.

摘要：Electrocatalysis is key to improving energy efficiency,reducing carbon emissions,and providing a sustainable way of meeting global energy ***,elucidating electrochemical reaction mechanisms at the electrolyte/electrode interfaces is essential for developing advanced renewable energy ***,the direct probing of real-time interfacial changes,i.e.,the surface intermediates,chemical environment,and electronic structure,under operating conditions is challenging and necessitates the use of in situ ***,we present a new lab-based instrument commissioned to perform in situ chemical analysis at liquid/solid interfaces using ambient pressure X-ray photoelectron spectroscopy(APXPS).This setup takes advantage of a chromium source of tender X-rays and is designed to study liquid/solid interfaces by the“dip and pull”*** of the main components was carefully described,and the results of performance tests are *** a three-electrode setup,the system can probe the intermediate species and potential shifts across the liquid electrolyte/solid electrode *** addition,we demonstrate how this system allows the study of interfacial changes at gas/solid interfaces using a case study:a sodium–oxygen model ***,the use of APXPS in electrochemical studies is still in the early stages,so we summarize the current challenges and some developmental *** the challenges,we expect that joint efforts to improve instruments and the electrochemical setup will enable us to obtain a better understanding of the composition–reactivity relationship at electrochemical interfaces under realistic reaction conditions.

摘要：Rapid capacity decay and inferior kinetics are the vital issues of anodes in the conversion reaction for lithium-ion *** engineering can efficiently modulate the intrinsic properties of transition-metal oxide(TMO)-based electrode materials,but the effect of oxygen vacancies on electrode performance remains ***,abundant oxygen vacancies are in situ introduced into the lattice of different TMOs(e.g.,Co_(3)O_(4),Fe_(2)O_(3),and NiO)via a facile hydrothermal treatment combined with *** Co_(3)O_(4)as a typical example,results prove that the oxygen vacancies in Co_(3)O_(4−x)effectively accelerate charge transfer at the interface and significantly increase electrical conductivity and pseudocapacitance *** Li-ion diffusion coefficient of Co_(3)O_(4−x) is remarkably improved by two orders of magnitude compared with that of Co_(3)O_(4).Theoretical calculations reveal that Co_(3)O_(4−x)has a lower Li-insertion energy barrier and more density of states around the Fermi level than Co_(3)O_(4),which is favorable for ion and electron ***,TMOs with rich vacancies exhibit superior cycling performance and enhanced rate capability over their *** strategy regulating the reaction kinetics would provide inspiration for designing other TMObased electrodes for energy applications.

摘要：Methanol to olefins(MTO)reaction as an important non-oil route to produce light olefins has been industrialized,and received over 80% ethylene plus propylene ***,to achieve high single ethylene or propylene selectivity towards the fluctuated market demand is still full of ***-pore SAPO-14 molecular sieve is a rare MTO catalyst exhibiting extra-high propylene *** provides us a valuable clue for further understanding of the relationship between molecular sieve structure and MTO catalytic *** this work,a seconds-level sampling fixed-bed reactor was used to capture real-time product distributions,which help to achieve more selectivity data in response to very short catalytic life of *** in product distribution,especially during the low activity stage,reflect valuable information on the reaction *** with in situ diffuse reflectance infrared Fourier-transform spectroscopy,in situ ultraviolet Raman measurements and ^(12)C/^(13)C isotopic switch experiments,a reaction pathway evolution from dual cycle to olefins-based cycle dominant was *** addition,the deactivation behaviors of SAPO-14 were also investigated,which revealed that polymethylbenzenes have been the deactivated species in such a *** work provides helpful hints on the development of characteristic methanol to propylene(MTP)catalysts.

摘要：A global climate prediction system （PCCSM4） was developed based on the Community Climate System Model, version 4.0, developed by the National center for Atmospheric Research （NCAR）, and an initialization scheme was designed by our group. Thirty-year （1981-2010） one-month-lead retrospective summer climate ensemble predictions were carded out and analyzed. The results showed that PCCSM4 can efficiently capture the main characteristics of JJA mean sea surface temperature （SST）, sea level pressure （SLP）, and precipitation. The prediction skill for SST is high, especially over the central and eastern Pacific where the influence of E1 Nino-Southem Oscillation （ENSO） is dominant. Temporal correlation coefficients between the pre- dicted Nino3.4 index and observed Nino3.4 index over the 30 years reach 0.7, exceeding the 99% statistical significance level. The prediction of 500-hPa geopotential height, 850-hPa zonal wind and SLP shows greater skill than for precipitation. Overall, the predictability in PCCSM4 is much higher in the tropics than in global terms, or over East Asia. Furthermore, PCCSM4 can simulate the summer climate in typical ENSO years and the interannual variability of the Asian summer monsoon well. These preliminary results suggest that PCCSM4 can be applied to real-time prediction after further testing and improvement.

摘要：Rationally designed heterostructures provide attractive prospects for energy storage electrodes by combining different active materials with distinct electrochemical ***,through a phase separation strategy,a heterostructure of SnO_(2) encapsulated by amorphous Nb_(2)O_(5) is spontaneously ***-type anode Nb_(2)O_(5) outer shell,playing as reaction containers and fast ionic pathways,physically inhibits the Sn atoms’migration and enhances the reaction ***,strong chemical interactions are found at the SnO_(2)/Nb_(2)O_(5) interfaces,which ensure the solid encapsulation of the SnO_(2) cores even after 500 *** used for lithium-ion batteries,this heterostructured anode exhibits high cycling stability with a capacity of 626 mAhg^(-1) after 1000 cycles at 2Ag^(-1)(85% capacity retention)and good rate performance with the capacity of 340 mAhg^(-1) at 8Ag^(-1).

摘要：Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of ***,their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial *** by the hunting behavior of spiders,here,a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture and killing of *** virtue of the initiative bacteriacapturing functionality,this spiderweb-like nanoagent could effectively attract and trap bacteria through electrostatic interaction and its reticular morphology ***,its synergetic antibacterial mechanism combining physical membranolysis with reactive oxygen species(ROS)release allows such nanoagent to harvest a promoted bactericidal ***,the woundplast employing the spiderweblike nanoagent exhibits a superior antibacterial efficacy against drug-resistant Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus compared with commercially available *** work may pave a new way for rational design of new generation bactericidal agents facing the future super-bacteria booming.