摘要：β-Lapachone (β-Lap) is a promising orthonaphthoquinone drug for cancer treatment and has been inclinical trials. Its application is constrained by the low aqueoussolubility, and severe side effects. Even prodrug designation isan effective approach to render it with tumor selectivity, it islimited by the lack of modifiable groups on β-Lap. Herein, anovel azo bond primary cleavage and carbon–carbon (C–C)bond secondary cleavage-based polymeric β-Lap prodrug(Azo-Lap NP) is designed, in which the self-immolated paraaminobenzyl linker is connected to poly(L-glutamic acid)(PGlu) via azo linkage and the responsive drug release of β-Lapagainst tumors can be achieved under high NAD(P)H:quinoneoxidoreductase 1 (NQO1) expression and low pH environmentin tumors. The effective covalent loading of β-Lap by Azo-LapNPs permitted a high administration dose of β-Lap and enabled significant tumor retention time. Moreover, Azo-LapNPs markedly reduced the side effects of β-Lap by avoidinghemolysis and the production of methemoglobin. The safety ofAzo-Lap NPs administration is validated in the antitumorexperiment of mice. In the 4T1 model, Azo-Lap NPs exhibiteda markedly higher tumor suppression rate than β-Lap. Thiswork provides an effective and safe polymeric prodrug fortumor selective delivery of β-Lap.

摘要：Fe/N/C material is the most competitive alternative to precious-metal catalysts for oxygen *** view of the present consensus on active centers,further effort is directed at maximizing the density of single Fe ***,the imperfections in commonly used doping strategy of Fe for the synthesis of zeolitic imidazolateframework(ZIF)-derived Fe/N/C catalysts are *** importantly,a strikingly improved catalyst is obtained by a‘second pyrolysis’method and delivers a half-wave potential of 0.825 V(***)in acidic *** strong confinement effect of carbonaceous host accounts for the formation of dense single-atom sites and thus the high *** findings will potentially facilitate future improvement of M/N/C catalysts.

摘要：A new index, i.e., the periphery representation of the projection of a molecule from 3D space to a 2D plane is described. The results, correlation with toxicity of substituted nitrobenzenes, obtained by using periphery descrip-tors are much better than that obtained by using the areas (i.e., shadows) of projections of the compounds. Even better results were achieved by using the combination of periphery descriptors and the projections areas as well as the indicated variable K reflecting the action of group NO2 position on the benzene ring.

摘要：We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring *** unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.

摘要：The development of high-performance oxygen evolution reaction catalysts with low iridium content is the key to the scale-up of proton exchange membrane water electrolyzer(PEMWE)for green hydrogen ***-site electrocatalysts with maximized atomic efficiency are held as promising candidates but still suffer from inadequate activity and stability in practical electrolyzer due to the low site ***,we proposed a NaNO_(3)-assistant thermal decomposition strategy for the preparation of high-density Ir single sites on MnO_(2)substrate(NaNO_(3)-H-Ir-MnO_(2)).Direct spectroscopic evidence suggests the inclusion of NaNO_(3) accelerates the transformation of Ir-Cl to Ir-O coordination,thus generating uniform dispersed high-density Ir single sites in the *** optimized H-Ir-MnO_(2)demonstrates not only high intrinsic activity in a three-electrode set-up but also boosted performance in scalable PEMWE,requiring a cell voltage of only 1.74 V to attain a high current density of 2 A cm^(-2) at a low Ir loading of 0.18 mgIr cm^(-2).This work offers a new insight for enhancing the industrial practicality of Ir-based single site catalysts.

摘要：The inte rmixed phase is important in effective charge separation due to the formation of cascaded energy landscape between intermixed phase and pure phases in polymer/fullerene solar ***,the quantitative relationship between the charge separation and the content of intermixed phase has not been investigated clearly so ***,we proposed to tune the content of the polymer/PC71BM intermixed phase by cha nging the polymer solution conformatio ***[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene](PBTTT)and PC71 BM was selected as a model *** organization of the PBTTT in solution promotes the formation of ordered aggregates as aging time increases,the interdigitation of side-chains restricts the intercalation of PC71 ***,the intermixed phase formed by intercalation PC71 BM to PBTTT side chain can be *** the aging time increasing from 0 to 80 min,the extent of inte rcalation gradually from almost complete intercalated phase to almost *** the content of intercalated phase is about 11%,the charge dissociation is most efficie nt and short circuit current(Jsc)increased from 1.60 mA/cm2 to 4.94 mA/cm2,leading to optimized device performance.

摘要：New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives（curdlan-Bochistidine, CUR-HIS）. The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L Na Cl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin（BSA） can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different p H values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.

摘要：Two macrocyclic polyoxazoles with different sizes and numbers of side chains were designed and synthesized from the linear-type precursors obtained by the iterative application of oxazole formation reaction via effective trimerization or dimerization respectively under highly diluted conditions in one pot.

摘要：A facile strategy was designed for the fabrication of Fe3O4-nanoparticle- decorated TiO2 nanofiber hierarchical heterostructures （FTHs） by combining the versatility of the electrospinning technique and the hydrothermal growth method. The hierarchical architecture of Fe3O4 nanoparticles decorated on TiO2 nanofibers enables the successful integration of the binary composite into batteries to address structural stability and low capacity. In the resulting unique architecture of FTHs, the 1D heterostructures relieve the strain caused by severe volume changes of Fe3O4 during numerous charge-discharge cycles, and thus suppress the degradation of the electrode material. As a result, FTHs show excellent performance including higher reversible capacity, excellent cycle life, and good rate performance over a wide temperature range owing to the synergistic effect of the binary composition of TiO2 and Fe304 and the unique features of the hierarchical nanofibers.

摘要：Organic electrode materials(OEMs)have attracted significant attention for use in aqueous zinc-ion batteries(AZIBs)because of their abundant resources and flexible ***,the development of high-performance OEMs is strongly hindered by their high solubility,poor conductivity,sluggish ion diffusion kinetics,and difficult coordination toward Zn^(2+).Herein,inspired by fabric crafts,we have designed a robust polymer fabric through the iterative evolution of the building blocks from point to line and *** evolution from point to line could not only improve the structural stability and electrical conductivity but also adjust the active site arrangement to enable the storage of Zn^(2+).In addition to further boosting the aforementioned properties,the evolution from line to plane could also facilitate the construction of noninterference channels for ion ***,the poly(1,4,5,8-naphthalenete tracarboxylic dianhydride/2,3,5,6-tetraaminocyclohexa-2,5-diene-1,4-dione)(PNT)polymer fabric has the most enhanced structural stability,optimized active site arrangement,improved electrical conductivity,and suitable ion channels,resulting in a record-high capacity retention of 96%at a high mass loading of 56.9 mg cm-2and a stable cycle life of more than 20,000 cycles at 150 C(1 C=200 mA g^(-1))in *** addition,PNT exhibits universality for a wide range of ions in organic electrolyte systems,such as Li/Na/K-ion *** iterative design of polymer fabric cathode has laid the foundation for the development of advanced OEMs to promote the performance of metal-ion batteries.