摘要：A novel degradable pH-sensitive hydrogel with pendent carboxyl groups was designed and synthesized from ethylenediaminetetraacetic dianhydride （EDTAh） and butanediamine （BDA） with dicyclohexylcarbodiimide （DCC） as a condensating agent and BDA as a crosslinking agent. The obtained polymers were characterized by ^13C NMR, ^1H NMR and FTIR. The swelling experiments of the hydrogel in pH 3, 7, and 12 media indicated much higher swelling ratio in pH 12 media than in pH 3 and pH 7 media, exhibiting sound pH sensitivity. The pH sensitivity of this type of hydrogel may be regulated through controlling the type and the dose of the crosslinking agent.

摘要：Titanium(Ti)and titanium alloys have become widely used as biomedical materials in orthopedics because of their good machinability,corrosion resistance,low elastic modulus and excellent ***,when Ti-based implants are used for bone repair and replacement,they are easy to cause bacteria adhesion and aggregation,which leads to postoperative *** addition,Ti and its alloys,as bio-inert materials,cannot induce desirable tissue responses such as osseointegration after implantation,which will eventually lead to implant *** bacterial infection and lack of osseointegration directly lead to the failure of implantation surgery and are not conductive to the long-term service of titanium-based ***,researchers have made many attempts to focus on the surface modification of multifunctional Ti-based implants to endow them with both antibacterial activity and simultaneous osteoinductive *** this review,we primarily highlighted the recent progresses in the surface design of Ti implants with both antimicrobial and osteoinductive properties for orthopedic ***,the challenges for treating implant-associated infections were briefly introduced such as the emergence of antibiotic resistance,the formation of biofilms,and the construction of cell-selective *** of the essential fundamentals were concisely introduced to address these emerging ***,we intended to elaborate the potential strategies of multifunctional surface design to endow good osseointegration for antibacterial Ti implants and highlighted the recent advances of the *** hope that this review will provide theoretical basis and technical support for the development of new Ti implant with antibacterial and osteogenic functions.

摘要：A new effective and fast minimization approach completely based on the physical theory is proposed for protein design. The sequence space is essentially searched according to the Boltzmann distribution. In this approach, the relative entropy is used as a minimization object function. The method has been tested on an off-lattice model of proteins and the results are better than those obtained from other similar work. Therefore, it can be applied as a uniform frame for both folding and inverse folding of proteins.

摘要：An on-demand wireless capsule endoscope with fulldigital and bidirectional communication is presented,aiming at fulfilling the requirements of micromation and micropower consumption of modern wireless *** proposed multifunctional operation and unique radio transmission system cuts down the power consumption efficiently and on-demand bidirectional communication in vitro improves the detection rate of ***,gray dilatation is introduced in a bit plane that optimizes the distortion rate in the process of image recording and transmission.

摘要：Laminar optical tomography(LOT)is a mesoscopic tomographic imaging technique ranging between confocal microscopy and diffuse optical tomography(DOT).Fluorescence LOT(FLOT)provides depth-resolved molecular information with 100-200μm resolution over 2-3mm *** this study,we use Monte Carlo simulation and singular-value analysis(SVA)to optimize the source-detector configurations for potential enhancement of FLOT imaging *** effects of different design parameters,including source incidence and detector collection angles,detector number,and sampling density,are *** results indicate that angled incidence/detection configuration might improve the imaging resolution and depth sensitivity,especially for low-scattering *** the number of detectors and the number of scanning steps will also result in enhanced imaging *** also demonstrate that the optimal imaging performance depends upon the background scattering coe±*** result might provide an optimization strategy for FLOT or LOT experimental setup.

摘要：A new positively thermo-sensitive hydrogel was designed and synthesized by a condensation polymerization reaction of ethylenediaminetetraacetic dianhydride（EDTAD） and piperazine（PA） to give poly（ethylenediaminetetraacetic dianhydride-copiperazine） （PEP）.The obtained polymers＇ structure was characterized by FTIR and ^（13）C *** backbone of the polymer linked by amide bond and abundant of carboxyl groups as pendant group could form strong intermolecular and intramolecular hydrogen bond at lower temperature and dissociate at higher temperature,resulting in the polymer with *** aqueous solution of PEP at lower temperature（〈20℃） showed micro-gel formation and transformed to transparent solution at higher temperature（〉40℃）.Transition temperature shifted to higher value with the increasing of *** hydrogel exhibited reversible phase transition and the transmittance change was not weakened by multiple temperature changes.

摘要：A series of novel 5-（trifluoromethyl）-1H-pyrazole-4-carboxamide derivatives（6a–6n, 7a, 7b, and 8a-8f）were synthesised by placing the amide bond at the 4-position of the pyrazole ring. These derivatives differed from the structure of chlorantraniliprole analogues with the amide bond at the 5-position of the pyrazole ring. Preliminary bioassay results revealed that a few title compounds exhibited good insecticidal activities against lepidopteran pests, such as Plutella xylostella, Mythimna separate, Heliothis armigera, and Ostrinia nubilalis. Some title compounds also elicited broad-spectrum insecticidal activities against dipterous insects including Culex pipiens pallens after altering the amide position. Similar to pyrazole-5-carboxamide analogues, compounds 6b and 6e showed 100% insecticidal activity against P. xylostella, C. pipiens pallens, and M. separate at concentrations of 200, 2, and 200 mg/m L, *** finding suggested that 5-（trifluoromethyl）-1H-pyrazole-4-carboxamide derivatives are potential alternative insecticides for management of agriculture pests.

摘要：A series of novel poly（urethane-urea）（PUU） was synthesized from poly（lactide-co-p-dioxanone） macrodiol（HO-P（LA-co-PDO）-OH）, hexamethylene diisocyanate（HDI） and butanediamine（BDA）.The obtained PUU,which is recorded as P（LA-co-PDO）-PUU here,may demonstrate enhanced phase separation and thus improved shape memory *** was employed to characterize the copolymers,and the effects of NCO/OH molar ratios on Tg of PUU was investigated by means of differential scanning calorimetry （DSC）.The results revealed the successful synthesis of P（LA-co-PDO）-*** addition,the Tg of P（LA-co-PDO）-PUU increased from 37.9℃to 44.2℃with the increase NCO/OH ratios from 1.1 to *** P（LA-co-PDO）-PUU with Tg close to body temperature will have potential applications as shape memory polymers in biomedical fields,especially in minimally invasive surgery.

摘要：To find new antiviral agents,novel chalcone derivatives containing a purine moiety were designed and synthesized by combining bioactive *** antiviral activities of the derivatives against tobacco mosaic virus （TMV） and cucumber mosaic virus （CMV） were *** showed that most of the derivatives showed antiviral *** 3n and 3p exhibited excellent curative,protective and inactivation activities against TMV,with the EC50values of 452.4,416.2,241.2 and 438.7,418.6,261.7 μg·mL-1,respectively,which were better than those of ribavirin （585.8,436.0 and 268.7 μg·mL-1）.Compounds 3n and 3p showed remarkable curative and protective activities against *** 3n showed a moderate affinity to TMV coat protein,with binding constant Ka and Kd values of 1.5 × 104 L·mol-1 and 79.8 μmol·L-1,*** findings provided an important structural insight for further designs of highly active chalcone derivatives and a basis for further study on their mechanism of action.

摘要：Cadaverine. a natural polyamine with multiple bioactivities that is widely distributed in prokaryotes and eukaryotes, is becoming an important industrial chemical. Cadaverine exhibits broad prospects for various applications, especially as an important monomer for bio-based polyamides. Cadaverine-based polyamide PA 5X has broad application prospects owing to its environmentally friendly characteristics and exceptional performance in water absorption and dimensional stability. In this review, we summarize recent findings on the biosynthesis, metabolism, and physiological function of cadaverine in bacteria, with a focus on the regu- latory mechanism of cadaverine synthesis in Escherichia coil （E. coli）. We also describe recent developments in bacterial production of cadaverine by direct fermentation and whole-cell bioconversion, and recent approaches for the separation and purification of cadaverine. In addition, we present an overview of the ap- plication of cadaverine in the synthesis of completely bio-based polyamides. Finally. we provide an outlook and suggest future developments to advance the production of cadaverine from renewable resources.