摘要：In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.

摘要：The rise of antibiotic resistance as one of the most serious global public health threats has necessitated the timely clinical diagnosis and precise treatment of deadly bacterial *** identify which types and doses of antibiotics remain effective for fighting against multi-drug-resistant pathogens,the development of rapid and accurate antibiotic-susceptibility testing(AST)is of primary *** methods for AST in well-plate formats with disk diffusion or broth dilution are both labor-intensive and operationally *** microfluidic chip provides a versatile tool for evaluating bacterial AST and resistant *** this paper,we develop an operationally simple,3D-printed microfluidic chip for AST which automatically deploys antibiotic concentration gradients and fluorescence intensity-based reporting to ideally reduce the report time for AST to within 5 *** harnessing a commercially available,digital light processing(DLP)3D printing method that offers a rapid,high-precision microfluidic chip-manufacturing capability,we design and realize the accurate generation of on-chip antibiotic concentration gradients based on flow resistance and diffusion *** further demonstrate the employment of the microfluidic chip for the AST of *** to representative clinical antibiotics of three classes:ampicillin,chloramphenicol,and *** determined minimum inhibitory concentration values are comparable to those reported by conventional well-plate *** proposed method demonstrates a promising approach for realizing robust,convenient,and automatable AST of clinical bacterial pathogens.

摘要：The discovery of COX-2 provides a novel target developing more effective NSAIDs with fewer side effects. On the basis of results from the structure-activity relationships (SAR) of selective COX-2 inhibitors, we have designed and synthesized some promising compounds.

摘要：这份报纸用适应观察员学习中立延期系统的差错评价的问题。一个新奇快适应差错评价(FAFE ) 算法首先基于适应观察员被建议包括快和精确性提高差错评价的表演。同时，一个延期依赖者标准被建立特别为小延期系统减少设计过程的保守主义。然后，全面分析被介绍用线性矩阵不平等(LMI ) 讨论精明的步技术。最后，模拟结果被介绍说明建议算法的效率。

摘要：An optimization model is constructed to formulate the maximization problem on the capacity of V-belt drive. The concavity,the monotonicity and the global optimality condition are studied for the objective function,and it is proved that the feasible region of the model is bounded,closed and convex under some design conditions. Then,a solution method,called an optimal segment algorithm,is developed to find the global maximizer of the model. Under four different design conditions,solution methods are presented respectively. Some real case studies are employed to demonstrate that the model and the algorithm in this paper are promising.

摘要：In this paper,we present a 3D printed tumor spheroidal model suitable for drug *** model is based on a hydroxyethyl cellulose/alginate/gelatin(HCSG)composite biomaterial that has three distinct properties:(1)the HCSG is similar to the commercial basement membrane extract in Ki67,MUC1,and PARP1 expressions of MCF-7 cells for embedding culture;(2)the HCSG is printable at room temperature;and(3)the HCSG can be large-scale manufactured at an ultralow *** printed a 3D MCF-7 spheroid model with HCSG and characterized it in terms of cell viability,spheroid size,key protein expression,and mitochondrial metabolic *** used the 3D MCF-7 spheroid model to evaluate the anti-breast cancer activity of 13 amino acid-based flavone phosphoramidates and found that the alanine structure induced a stronger drug resistance,whereas phenylalanine hardly caused drug resistance in the MCF-7 *** is the first time that 3D bioprinting technology has been used in a structure–activity relationship study.

摘要：目的本研究旨在评估在埃塞俄比亚哈瓦萨希达莫地区公立医院提供孕产保健服务的护士和助产士对关怀行为的感知及相关因素。方法采用横断面研究设计,对该地区公立医院产科病房的269名护士和助产士进行抽样调查。使用自填问卷收集数据。采用多变量logistic回归分析确定与护士和助产士感知关怀行为关联的因素。结果共261名护士和助产士参与此项调查。依据调查获得的平均得分,将护士和助产士感知关怀行为分为较高和较低水平。本研究中,75.1%(196/261)的护士和助产士感知关怀行为水平较高。调查对象的年龄、职业满意度、个人满意度、助产士/护士-医生关系和工作量与他们的感知关怀行水平存在关联。结论评估护士和助产士的感知关怀行水平和关联因素对提供高质量护理和助产干预至关重要。建议通过减轻护士和助产士的过高工作负荷,改善护士/助产士与医生的关系,并通过表彰和奖励提高他们的工作满意度,来营造积极的关怀氛围,以改善护士和助产士的关怀行为。

摘要：A metal plate cooling model for 400~ single concentrator solar cells was established. The effects of the thickness and the radius of the metal plate, and the air environment on the temperature of the solar cells were analyzed in detail. It is shown that the temperature of the solar cells decreased sharply at the beginning, with the increase in the thickness of the metal plate, and then changed more smoothly. When the radius of the metal plate was 4 cm and the thickness increased to 2 mm or thicker, the temperature of the solar cell basically stabilized at about 53℃. Increasing the radius of the metal plate and the convective transfer coefficient made the temperature of the solar cell decrease remarkably. The effects of A1 and Cu as the metal plate material on cooling were analyzed contrastively, and demonstrated the superiority of A1 material for the cooling system. Furthermore, considering cost reduction, space holding and the stress of the system, we optimized the structural design of the metal plate. The simulated results can be referred to the design of the structure for the metal plate. Finally, a method to devise the structure of the metal plate for single concentrator solar cells was given.

摘要：本研究利用结构设计理念将TiNCl应用于高倍率锂离子电池,并解释其储能机理.由于Ti-N层的高导电性,它可作为电子导电单元.由Cl层构成的多面体通道有助于锂离子的传输,并作为离子传输单元.此外,由于TiNCl中的Cl带负电的特性,负极材料在1 mV s^(-1)下的赝电容贡献率高达99.5%.而在50 C的高倍率下,经过1000次循环后,它依旧保持极高的可逆比容量(202 mA h g^(-1)).这种基于结构单元的设计理念对于研发高性能新型电极材料具有指导意义.

摘要：本文设计合成了两种具有不同连接方式(亚胺键和sp^(2)-C-CN键)的三嗪基共价有机框架(COFs)材料.连接单元的微小变化导致可见光驱动制氢性能的巨大差异.具有sp^(2)碳连接方式的全π共轭二维COFs在450 nm波长处表现出13.48%的外量子效率,优于已报道的COFs光催化剂.而亚胺键的二维COFs几乎没有光活性.借助光电化学研究和量子化学计算进一步研究了二维COFs的催化机理,为太阳能转化高性能有机光催化剂的制备提供了新的见解.