摘要：Nanomaterials are materials in which at least one of the dimensions of the particles is 100 nm and *** are many types of nanomaterials,but noble metal nanoparticles are of interest due to their uniquely large surface-to-volume ratio,high surface area,optical and electronic properties,high stability,easy synthesis,and tunable surface *** importantly,noble metal nanoparticles are known to have excellent compatibility with bio-materials,which is why they are widely used in biological *** synthesis method of noble metal nanoparticles conventionally involves the reduction of the noble metal salt precursor by toxic reaction agents such as NaBH4,hydrazine,and *** is a major drawback for researchers involved in biological application ***,the bio-synthesis of noble metal nanoparticles(NPs)by bio-materials via bio-reduction provides an alternative method to synthesize noble metal nanoparticles which are potentially non-toxic and safer for biological *** this review,the bio-synthesis of noble metal nanoparticle including gold nanoparticle(AuNPs),silver nanoparticle(AgNPs),platinum nanoparticle(PtNPs),and palladium nanoparticle(PdNPs)are first *** is followed by a discussion of these biosynthesized noble metal in biological applications including antimicrobial,wound healing,anticancer drug,and *** on these,it can be concluded that the study on bio-synthesized noble metal nanoparticles will expand further involving bio-reduction by unexplored ***,many questions remain on the feasibility of bio-synthesized noble metal nanoparticles to replace existing methods on various biological ***,the current development of the biological application by bio-synthesized noble metal NPs is still intensively ongoing,and will eventually reach the goal of full commercialization.

摘要：Water electrolysis technology holds the perfect promise of the hydrogen production,yet control of efficiency and rate of water electrolysis greatly relies on the availability of high-performance electrode materials for kinetic-sluggish oxygen evolution reaction(OER).Accordingly,substantial endeavors have been made to explore advanced electrode materials over the past ***,RuO_(2) and RuO_(2)-based materials have been demonstrated to be promising for OER due to their remarkable electrocatalytic activity and pH-universal ***,the great achievements and progresses of this flourishing spot are comprehensively reviewed,which are started by a general description of OER to understand the reaction mechanism in ***,the key advantages and issues of RuO_(2) towards OER are also introduced,followed by proposing many advanced strategies for further promoting the electrocatalytic OER performance of RuO_(2).Finally,the daunting challenges and future progresses of RuO_(2) electrocatalysts toward practical water oxidation are highlighted,aiming to provide guidance for the fabrication of desirable RuO_(2)-based electrocatalysts toward OER.

摘要：A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines（PC-3, LNCa P, and DU145） were evaluated by a CCK-8 assay. Compounds 8, 10, 13, 17 and 20 exhibited strong cytotoxic activities against the tested cancer cell lines（IC_（50）〈3 μmol/L）. In addition, these compounds exhibited weak cytotoxic effects on human epithelial prostate normal cells WPMY-1. The structure-activity relationship（SAR） of these arylpiperazine derivatives was also discussed based on the obtained experimental data.

摘要：Aimed at solving continuous optimum parameter problems effectively in added drug design, this paper develops a novel ant algorithm termed continuous gridded ant colony （CGAC）, where the spy ants are utilized to search the latent optimum grid in the domain completely and effectively. In order to test the effect, the CGAC algorithm was success in finding the best values of C and y, when the support vector machine （SVM） was used to fit the nonlinear relationship between the numerical representation of the chemical structure and IC50. The genetic algorithm （GA） was also used to obtain the appropriate feature subset simultaneously, because feature subset selection influences the appropriate kernel parameters and vice versa. The obtained results illustrate that GA-CGAC-SVM models have satisfactory prediction accuracy. The best quantitative modeling results in thirteen-descriptors model based on GA-CGAC-SVMr with mean-square errors 0.397, a predicted correlation coefficient （R2） 0.842, and a cross-validated correlation coefficient （Q^2） 0.756. The best classification result was found using SVM： the percentage （%） of correct prediction based on 7-fold cross-validation was 90.6%. The results demonstrate that the proposed CGAC algorithm provides a new and effective method to find the optimum parameters when the SVM tool is used.

摘要：Cytochrome P450 OleT_(SA),a new cytochrome P450 enzyme from Staphylococcus aureus,catalyzes the oxidative decarboxylation and hydroxylation of fatty acids to generate terminal alkenes and fatty *** mechanism of this bifurcative chemistry remains largely ***,a class of derivatized fatty acids were synthesized as probes to investigate the effects of substrate structure on the product type of P450 OleT_(SA).The results demonstrate that the fine-tuned structure of substrates,even in a remote distance from the carboxyl group,significantly regulates OleT catalyzed decarboxylation/hydroxylation *** docking analysis indicated the potential interactions between the carboxylate groups of different probes and the enzyme active center which was attributed to the bifurcative chemistry.

摘要：On the basis of the FLP (frustrated Lewis pair) principle, a new strategy has been proposed to construct the "frustration" in de- signing metal-free hydrogen activation compounds, by using FMO (frontier molecular orbital) analyses and quantum mechanics calculations. Unlike the known FLPs which use bulky substituents to prevent them from forming stable Lewis acid/base com- plexes, the new approach encumbers the intramolecular π donation from the electron donor to the acceptor (e.g. in BH2NH2) by using a CH2 bridge (giving BH2CH2NH2). The strategy is simple and effective. Its effectiveness is demonstrated by the small hy- drogen activation energy (12.0 kcal/mol) of the model molecule (BH2CH2NH2), which is significantly less than the 42.7 kcal/mol of BH2NH2 and also less than the 18.5 kcal/mol of BH2PH2 whose derivative, R2PB(C6F5)2, has been experimentally shown to be able to activate hydrogen. We also exemplified how to use the strategy to design experimentally more realizable molecules. The example shows promises as a hydrogen activation agent. The strategy can be used to design metal-free catalysts for direct hydro-genation.

摘要：Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing *** to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly *** near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/*** this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR ***,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of ***,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence *** includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence *** the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed.

摘要：A novel degradable pH-sensitive hydrogel with pendent carboxyl groups was designed and synthesized from ethylenediaminetetraacetic dianhydride （EDTAh） and butanediamine （BDA） with dicyclohexylcarbodiimide （DCC） as a condensating agent and BDA as a crosslinking agent. The obtained polymers were characterized by ^13C NMR, ^1H NMR and FTIR. The swelling experiments of the hydrogel in pH 3, 7, and 12 media indicated much higher swelling ratio in pH 12 media than in pH 3 and pH 7 media, exhibiting sound pH sensitivity. The pH sensitivity of this type of hydrogel may be regulated through controlling the type and the dose of the crosslinking agent.

摘要：We have theoretically investigated two series of cyclometalated Pt（II） complexes, a series [Pt （C, N, N） Cl] and b series [Pt （C, N, Npyrazolyl） Cl]. The geometrical and electronic structures are calculated at the ECP60MWB//6-31G＊（H, C, Cl, N, S） basis set level using DFT method; one-photon absorption （OPA） properties are calculated by using both TDDFT and ZINDO methods and two-photon absorption （TPA） properties are obtained with the ZINDO/SOS method. The resonance integrals parameters （βsp and βd） for Pt are adjusted to -1 and -28.5 eV, respectively, to make max OPA wavelength calculated by ZINDO closest to the experimental data and TDDFT results. The calculated results indicate the molecule 2b （[Pt （Cnaphthyl, N, Npyrazolyl） Cl]） has the biggest potential as outstanding TPA materials because （i） the TPA properties of b series are more outstanding in IR wavelength range, the molecules in b series have good transparencies and possess 1-pyrazolyl-NH that is also available for another metal coordination （e.g., dimerization） and chemical interactions; （ii） when C is CnaphthyI in the C, N, N ligand of cyclometalated Pt（II） complexes, the molecules have the best conjugation effect and the best TPA properties.

摘要：To enhance the performance of the polyphenylene sulfone(PPSU) membrane,a novel mixed matrix membrane with hydrophilicity and antifouling properties was *** PPSU as the ba sic membrane material,polyvinyl pyrrolidone(PVP) as the porogen,N-Methyl pyrrolidone(NMP) as the solvent,and MOF-CAU-1(Al_(4)(OH)_(2)(OCH_(3))_4(H_2 N-BDC)_(3)·xH_(2) O) as the filler,PPSU/CAU-1 mixed matrix membrane(MMM) was prepared by an immersion precipitation and phase transformation *** changing the amount of MOF-CAU-1,the properties and performance of the MMM membrane were investigated in terms of hydrophilicity,pore morphology,surface roughness,and dye *** results show that the highest pure water flux of the mixed reached 47.9 L·m^(-2)·h^(-1), when the CAU-1 addition amount was 1.0 wt%, which was 23% higher than that of the pure PPSU *** the rejection rate and the antifouling performance of the MMM membrane also noticeably improved.