摘要：由于C=C双键交联反应机制的成熟,金属氧化物光刻胶得到了广泛的发展.然而,由于不稳定的C=C双键,这种材料需要低温和遮光存储.在此,首次在金属氧簇中提出了C-F键交联策略用于光刻图案化.以光刻胶Zn-TBA为例,它形成光滑无缺陷的薄膜,且表面粗糙度Rq小于0.2 nm.使用极紫外(EUV)干涉掩模,在65 mJ cm^(-2)曝光剂量下形成37.5 nm的半周期(HP)图案.在EUV曝光和正己烷显影后,通过原子力显微镜(AFM)观察到负性光刻胶形貌.重要的是,Zn-TBA可以在室温和明亮的环境中储存.除了脱羧之外,我们还提出光引发的C-F交联是Zn-TBA图案的主要贡献者,并通过高分辨率X射线光电子能谱(HRXPS)和密度泛函理论(DFT)计算得以证明.这种新颖的光刻机制为下一代金属基材料的设计提供了新的思路.

摘要：Hirudin，凝血酵素的大多数有势力禁止者在自然发现了，在浆液有短半衰期，它显著地作为抗凝剂限制它的临床的申请。最近， PEGylation 通常被用作一个有效方法在浆液延长它的半衰期。与在随机指向离氨酸残余的基本条件下面的非特定的 PEGylation 相对照，在略微酸的条件下面的 PEGylation 地点最好指向 histidine 残余，并且仅仅在 r-hirudin 在 51 点有一 histidine 残余；因此， succinimidyl 羰基 methoxy 聚乙烯乙二醇(SC-mPEG， 20000 ) 在略微酸的 pH 被纳入 r-hirudin 赞成 mono-PEGylated r-hirudin 的形成。有高 mono-PEGylated 比率的反应混合被一步舞离子交换容易分开色析法(IEC ) 过程。约 79.71% mono-PEGylated r-hirudin 是在 His51 的 PEGylated，它证明酸的 PEGylation 操作原则上阻止了 r-hirudin 的活跃中心(Lys47 ) 的 PEGylation。有比 95% 高的纯净的 Mono-PEGylated 产品作为占优势的产品被获得，并且 34% 抗凝剂活动在 vitro 被保留。为钠 dodecyl 硫酸盐 polyacrylamide 胶化电气泳动(SDS 页) 的染色的方法被改进在不到 5min 获得完美的 electrophoretic 模式。更精确的分子的重量作为分子的重量标准由于木钉的使用被推出。

摘要：Evolutionary algorithms (EAs) were shown to be effective for complex constrained optimization problems. However, inflexible exploration in general EAs would lead to losing the global optimum nearby the ill-convergence regions. In this paper, we propose an iterative dynamic diversity evolutionary algorithm (IDDEA) with contractive subregions guiding exploitation through local extrema to the global optimum in suitable steps. In IDDEA, a novel optimum estimation strategy with multi-agents evolving diversely is suggested to efficiently compute dominance trend and establish a subregion. In addition, a subregion converging iteration is designed to redistrict a smaller subregion in current subregion for next iteration, which is based on a special dominance estimation scheme. Meanwhile, an infimum penalty function is embedded into IDDEA to judge agents and penalize adaptively the unfeasible agents with the lowest fitness of feasible agents. Furthermore, several engineering design optimization problems taken from the specialized literature are successfully solved by the present algorithm with high reliable solutions.

摘要：The rational design of the sample cell may improve the sensitivity of surface-enhanced Raman scattering （SERS） detection in a high degree. Finite difference time domain （FDTD） simulations of the configuration of Ag film-Ag particles illuminated by plane wave and evanescent wave are performed to provide physical insight for design of the sample cell. Numerical solutions indicate that the sample cell can provide more ＂hot spots＂ and the massive field intensity enhancement occurs in these ＂hot spots＂. More information on the nanometer character of the sample can be got because of gradient-field Raman （GFR） of evanescent wave. OCIS codes： 290.5860, 240.0310, 240.6680, 999.9999 （surface-enhanced Raman scattering）.

摘要：Current universe (assumed here to be normal matter on the brane) is pressureless from *** this case the energy condition is ρ_0≥0 and p0=*** using this condition,brahe models can be ***, assuming arbitrary component of matter in DGP model,we use four known energy conditions to study the matter on the *** there is nonnormal matter or energy (for example dark energy with w<-1/3) on the brahe,the universe is accelerated.

摘要：细菌对抗生素产生耐药性是引起公共卫生问题的主要因素.高效无抗生素杀菌剂对抗细菌感染相关疾病具有重要意义.本文采用溶剂热法,以有机杀菌剂或合成杀菌剂中间体为碳源,合成了具有宽吸收(350-700 nm)范围的红色荧光发射碳点(R-CDs).所合成的R-CDs不仅具有固有的抗菌活性,还可以通过590 nm光激发产生活性氧(ROS)有效杀死多耐药细菌(多耐药鲍曼不动杆菌(MRAB)和多耐药金黄色葡萄球菌(MRSA)).此外,R-CDs可有效消除MRAB表面生物膜并进一步抑制其再生能力,能够加速由细菌感染的伤口愈合速度,而对正常细胞的副作用很小.因此,这种非抗生素为碳源的碳点合成新策略为下一代抗耐药细菌药物的设计提供了参考.

摘要：This paper introduces a non-iterative algorithmic procedure to design water utilization networks with multiple contaminants in process plants. According to the water pinch analysis rules, the processes in water utilization systems were first divided into three groups, then water-supply priority algorithm was proposed. The results of case studies showed that the water networks designed by this method gave water consumption lower than that estimated by other approaches. In addition, the procedure was subiect to no limitation on the problem scale.

摘要：Proposes a simplified finite element model for steel-concrete composite beams. The effects of slip can be taken into account by creating a special matrix of shear connector stiffness and using the iteration method. Meanwhile, the effect of material non-linearity of steel and concrete on rigidity and strength of composite beams is considered. With the age-adjusted effective modulus method, the analysis for the whole process of shrinkage and creep under long-term load can be performed. The ultimate load, deflection, stress and slip of continuous composite beams under short-term and long-term load are computed using the proposed finite element model. The numerical results are compared with the experimental results and existing values based on other numerical methods, and are found to be in good agreement.

摘要：Mesh parameterization is one of the fundamental operations in computer graphics(CG) and computeraided design(CAD). In this paper, we propose a novel local/global parameterization approach, ARAP++, for singleand multi-boundary triangular meshes. It is an extension of the as-rigid-as-possible(ARAP) approach, which stitches together 1-ring patches instead of individual triangles. To optimize the spring energy, we introduce a linear iterative scheme which employs convex combination weights and a fitting Jacobian matrix corresponding to a prescribed family of transformations. Our algorithm is simple, efficient, and robust. The geometric properties(angle and area)of the original model can also be preserved by appropriately prescribing the singular values of the fitting matrix. To reduce the area and stretch distortions for high-curvature models, a stretch operator is introduced. Numerical results demonstrate that ARAP++ outperforms several state-of-the-art methods in terms of controlling the distortions of angle, area, and stretch. Furthermore, it achieves a better visualization performance for several applications, such as texture mapping and surface remeshing.

摘要：Topology optimization is a powerful design approach that is used to determine the optimal topology in order to obtain the desired functional performance. It has been widely used to improve structural performance in engineering fields such as in the aerospace and automobile industries. However, some gaps still exist between topology optimization and engineering application, which significantly hinder the application of topology optimization. One of these gaps is how to interpret topology results, especially those obtained using the density framework, into parametric computer-aided design (CAD) models that are ready for subsequent shape optimization and manufacturing. In this paper, a new method for interpreting topology optimization results into stereolithography (STL) models and parametric CAD models is proposed. First, we extract the skeleton of the topology optimization result in order to ensure shape preservation and use a filtering method to ensure characteristics preservation. After this process, the distribution of the nodes in the boundary of the topology optimization result is denser, which will benefit the subsequent curve fitting. Using the curvature and the derivative of curvature of the uniform B-spline curve, an adaptive B-spline fitting method is proposed in order to obtain a parametric CAD model with the fewest control points meeting the requirement of the fitting error. A case study is presented to provide a detailed description of the proposed method, and two more examples are shown to demonstrate the validity and versatility of the proposed method.