摘要：Objective:To find potential peptide inhibitors against the NS2B/NS3 protease of DENV which in turn,can inhibit the viral replication inside host ***:Cyclic peptides were designed having combination of positively charged amino acids using ChemSketch software and were converted to 3D *** NS3 protein structure was retrieved from Protein Data Bank(PDB)using PDB Id:*** NS3 and cylic peptides were docked using MOE software after structural ***:Through molecular docking it was revealed that most of the peptides bound deeply in the binding pocket of DENV NS2B/NS3 protease an had interactions with catalytic *** 2 successfully blocked the catalytic triad of NS2B/NS3 *** 1,,4 and 6 also had potential interactions with active residues of the NS2B/NS3 protease while all other peptides were in close contact with the active sites of NS2B/NS3 protease thus,these peptides can serve as a potential drug candidate to stop viral ***:*** can be concluded from the study that these peptides could serve as important inhibitors to inhibit the viral replication and need further in-vitro investigations to confirm their efficacy.

摘要：Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for ***,many disease mechanisms and drug effects generated from animal models are not transferable to *** address these issues,we developed SysFinder（http：//***/SysFinder）,a platform for scientists to find appropriate animal models for translational *** offers a ＂topic-centered＂ approach for systematic comparisons of human genes,whose functions are involved in a specific scientific topic,to the corresponding homologous genes of animal *** topic can be a certain disease,drug,gene function or biological *** calculates multi-level similarity indexes to evaluate the similarities between human and animal models in specified scientific ***,SysFinder offers species-specific information to investigate the differences in molecular mechanisms between humans and animal ***,SysFinder provides a userfriendly platform for determination of short guide RNAs（sgRNAs） and homology arms to design a new animal *** studies illustrate the ability of SysFinder in helping experimental *** is a useful platform for experimental scientists to carry out their research in the human molecular mechanisms.