摘要：Shape memory materials possess programmable complex and large deformations towards external stimuli,which are particularly essential for their potential *** the transformation of planar two-dimensional(2D)structures into complex 3D structures,the design of asymmetric or bilayer thin sheets is usually *** this paper,we propose a facile strategy to achieve these complex 3D structures that can be transformed to various pre-determined shapes sequentially by laser-triggered site-specific *** response of shape memory polycaprolactone(PCL)to laser is realized by physically dopingW18O49 nanowires into the cross-linked PCL diacrylate *** irradiated by 98 mW cm^(−2)laser,the pre-stretched PCL/W_(18)O_(49)film shows an out-of-plane bending deformation due to the temperature gradient and single-domain orientation on the thickness between the upper layer and lower *** bending rates and amplitudes of the film can be tailored by adjusting the parameters of irradiation time,the film thickness as well as the pre-stretch ***,the pre-stretched film can automatically bend in more intricate complex deformations by integration with kirigami cuts in ***,we demonstrate that by activating the dynamic transesterification reaction within the same film,it can also achieve the 2D-to-3D *** these decent features,this kind of novel PCL//W_(18)O_(49)film shows great potential in the field of biomedical devices or soft robotics.

摘要：过渡金属氧化物(TMOs)用作电极材料时,会在循环过程中产生严重的体积变化,并且其自身的导电率也较低,因此它的电化学性能较差.设计和开发独特的TMOs纳米结构并将其与导电碳基底相结合是改善其电化学性能的有效策略.本工作中,我们设计了一种C/Cu多孔微球,并通过原位合成在碳壁上垂直生长Co_(3)O_(4)纳米片.作为导电基底,C/Cu多孔微球提供了多尺度孔隙网络和大的电极/电解质接触界面,显著改善了电子和离子扩散动力学.原位合成的Co_(3)O_(4)纳米片牢牢地固定在碳壁上,从而提高了复合微球在长期循环中的结构稳定性.得益于独特的结构特征,用作锂离子电池负极材料的C/Cu@Co_(3)O_(4)复合多孔微球表现出优异的倍率性能、高充电比容量和出色的循环稳定性.

摘要：Recently, the anti-glycation and anticancer properties of curcumin longa and okra seed extract were studied alone and also in combination with the well-established drug metformin. The combined effect of curcumin with metformin and metformin with okra seed extract was found to be highly efficacious in inhibiting Advanced Glycation End-products （AGEs）. In order to understand the mechanistic implications of curcumin combined with metformin and its enhanced anti-glycation activity, a Curcumin-Metformin Adduct was chemically synthesized. This adduct was fully characterized by thin-layer chromatography, Nano Drop spectrophotometry and electrospray-ionization mass spectrometry. The adduct may be helpful not only in elucidating the mechanism of anti-glycation and anti-cancer activities but also in studying the role of curcumin in binding of AI3-oligomers and disaggregating fibrillar formation in Alzheimer＇s disease.

摘要：Structural colors,derived from existing natural creatures,have aroused widespread attention in the materials regulation for different ***,inspired by the color adjusting mechanism of hummingbird,we present a novel shape-memory structural color hydrogel film by introducing shape memory polymers(SMPs)into synthetic inverse opal scaffold *** excellent flexibility as well as the inverse opal structure of the hydrogel films imparts them with stable stretchability and brilliant structural *** from the transient structural anisotropy of copolymers,the hybrid films are possessed with shape-morphing behaviors *** on the shape transformations and color responsiveness performance,we have demonstrated diverse structural color actuators with complex shapes for different ***,as the photothermal responsive graphene quantum dots were integrated into the hydrogel,the hybrid films could also be endowed with the feature of light-controlled reversible deformation with synchronous structural color *** features demonstrate that the presented shape-memory structural color hydrogel film is valuable for soft robotics with multifunctions of sensing,communication and disguise.

摘要：Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 in vitro and in vivo,representing a viable therapeutic strategy for cancer *** phage display techniques,we previously identified a potent peptide activator of P53,termed PMI(TSFAEYWNLLSP),with binding affinities for both MDM2 and MDMX in the low nanomolar concentration *** we report an ultrahigh affinity,dual-specificity peptide antagonist of MDM2 and MDMX obtained through systematic mutational analysis and additivitybased molecular *** assays of over 100 peptide analogs of PMI using surface plasmon resonance and fluorescence polarization techniques yielded a dodecameric peptide termed PMI-M3(LTFLEYWAQLMQ)that bound to MDM2 and MDMX with K_(d)values in the low picomolar concentration range as verified by isothermal titration ***-crystal structures of MDM2 and of MDMX in complex with PMI-M3 were solved at 1.65 and 3.0 A resolution,*** to PMI,PMI-M3 occupied the P53-binding pocket of MDM2/MDMX,which was dominated energetically by intermolecular interactions involving Phe3,Tyr6,Trp7,and Leu *** differences in binding between PMI-M3 and PMI were observed at other positions such as Leu4 and Met11 with MDM2,and Leu1 and Met11 with MDMX,collectively contributing to a significantly enhanced binding affinity of PMI-M3 for both *** adding lysine residues to both ends of PMI and PMI-M3 to improve their cellular uptake,we obtained modified peptides termed PMI-2K(KTSFAEYWNLLSPK)and M3-2K(KLTFLEYWAQLMQK).Compared with PMI-2K,M3-2K exhibited significantly improved antitumor activities in vitro and in vivo in a P53-dependent *** super-strong peptide inhibitor of the P53-MDM2/MDMX interactions may become,in its own right,a powerful lead compound for anticancer drug development,and can aid molecular design of other classes of P53 activators as well for anticancer therapy.

摘要：In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked based on their interaction with breast tumor receptor binding target Bcl-2. The docking resulted in the five top-ranked compounds, namely, compounds 11, 14, 15, 16, and 20, which have a lower G binding energy, better affinity and stronger hydrogen bonding interactions to the active site of Bcl-2 than antimycin A3. Among those five top-ranked compounds, analogue compounds 11 and 14, which have an 18-membered tetralactone core and 18-membered tetraol core, respectively, exhibited the strongest hydrogen bond interaction, formed high stability conformation, and demonstrated the greatest inhibitory activity on the catalytic site of Bcl-2.

摘要：肿瘤微环境中的血管生成是肿瘤细胞对放化疗不敏感的主要原因.在本项研究中,我们设计了一种微环境响应型的纳米颗粒,利用ZrMOF的分解产物抑制肿瘤细胞中的PI3K/AKT/mTOR/VEGF通路,从而克服A549R细胞对顺铂的耐药性.我们将顺铂包裹在Zr-MOF中,并在表面修饰BSA,形成了CDDP@Zr-MOF-BSA纳米复合体,该复合体在肿瘤微环境中有良好的响应性,有助于在肿瘤区域蓄积,展现出卓越的血管生成抑制能力,并能明显降低药物的外排.此外,CDDP@Zr-MOFBSA能显著抑制多药耐药相关蛋白1(MRP1)的表达,从而逆转A549R细胞的耐药性.总体而言,CDDP@Zr-MOF-BSA对A549R有细胞毒性,能抑制肿瘤微环境中的血管生成,最终有效提高顺铂耐药肿瘤的治疗效果.CDDP@Zr-MOF-BSA为放化疗治疗耐药肿瘤提供了一种多功能协同的方法.

摘要：Malaria still threatens global health seriously *** the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors,multi-targeting inhibitors are highly desired to overcome the increasingly serious drug ***,we performed a structure-based drug design on mitochondrial respiratory chain of Plasmodium falciparum and identified an extremely potent molecule,RYL-581,which binds to multiple protein binding sites of *** simultaneously(allosteric site of type Ⅱ NADH dehydrogenase,Q_(o) and Q_(i) sites of cytochrome bc_(1)).Antimalarials with such multiple targeting mechanism of action have never been reported ***-581 kills various drug-resistant strains in vitro and shows good solubility as well as in vivo *** structurebased strategy for designing RYL-581 from starting compound may be helpful for other medicinal chemistry projects in the future,especially for drug discovery on membrane-associated targets.

摘要：目的本研究旨在确定护士对家属在场时实施复苏的自信心与实践之间的关系,并描述护士对相关情形的偏好。方法采用横断面调查方法,研究对象来自肯尼亚西阿亚县转诊医院内外科不同单元。采用匿名自填问卷进行调查,主要测量工具为Twibel等设计的家属在场自信量表(Family Presence Self-confi-dence Scale)。采用χ^(2)检验和二元回归分析进行统计学分析。结果护士对家属在场时实施复苏操作的自信心与实践存在关联(χ^(2)=8.060,P=0.01)。非常自信的护士在临床实践中实施家属在场情况下复苏操作的可能性是有点自信的护士的4.9倍(OR=4.94,95%CI 1.07~22.71)。结论护士对实施家属在场复苏操作的自信心差异较大。为成功实施家属在场复苏实践,护士还需通过更多专门培训和实践获得更高水平的自信心。

摘要：Efficacious regulation of the geometric and electronic structures of carbon nanomaterials via the introduction of defects and their synergy is essential to achieving good electrochemical ***,the guidelines for designing hybrid materials with advantageous structures and the fundamental understanding of their electrocatalytic mechanisms remain ***,superfine Pt and PtCu nanoparticles supported by novel S,N‐co‐doped multi‐walled CNT(MWCNTs)were prepared through the innovative pyrolysis of a poly(3,4‐ethylenedioxythiophene)/polyaniline copolymer as a source of S and *** uniform wrapping of the copolymer around the MWCNTs provides a high density of evenly distributed defects on the surface after the pyrolysis treatment,facilitating the uniform distribution of ultrafine Pt and PtCu ***,the Pt_(1)Cu_(2)/SN‐MWCNTs show an obviously larger electroactive surface area and higher mass activity,stability,and CO poisoning resistance in methanol oxidation compared to Pt/SN‐MWCNTs,Pt/S‐MWCNTs,Pt/N‐MWCNTs,and commercial Pt/*** functional theory studies confirm that the co‐doping of S and N considerably deforms the CNTs and polarizes the adjacent C ***,both the adsorption of Pt1Cu2 onto the SN‐MWCNTs and the subsequent adsorption of methanol are enhanced;in addition,the catalytic activity of Pt_(1)Cu_(2)/SN‐MWCNTs for methanol oxidation is thermodynamically and kinetically more favorable than that of its CNT and N‐CNT *** work provides a novel method to fabricate high‐performance fuel cell electrocatalysts with highly dispersed and stable Pt‐based nanoparticles on a carbon substrate.